Presentation on theme: "Product Training Series"— Presentation transcript:
1Product Training Series Cholestin®Product Training SeriesThis material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.
2New & Improved Cholestin® Cholestin contains policosanol, a novel ingredient extracted from beeswaxPolicosanol is clinically proven*safe, effective, and well-toleratedProprietary PoliSorb™ † softgel deliveryConvenient once-a-day dosagePharmanex is first to market in the USPharmanex has exclusive rights for the network marketing channel†Policor is a trademark of Hauser, Inc.
3NCEP Cholesterol Guidelines From: Third report of the National CholesterolEducation Program Expert Panel, May 2001
4NCEP Cholesterol Guidelines Using NCEP guidelines,about 65 million Americansshould make dietary and lifestyle changesto maintain cardiovascular health
5Cholestin® : Health Benefits Maintains existing normal cholesterol levels*Total & LDL-CholesterolHDL-CholesterolLDL/HDL RatioTriglyceridesHelps prevent oxidation of LDL cholesterol*Promotes normal blood fluidity** These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
6History of Policosanol Perez teams up with top-quality pharmaceutical company; now supplierEarly 90’s: Beeswax policosanol initially sourced in CubaSugarcane policosanol clinically tested and commercialized in CubaMid 90’s: Sugar cane policosanol suggested as more economical source Cuban governmentPedro P. Perez revives R&D work in US for beeswax policosanol2001: Pharmanex launches Cholestin® - beeswax policosanol
7Cholestin Composition Primary Active Constituent:Policosanol from Beeswax (PolicorTM )†Novel ingredient - “Cholesterol Breakthrough”Extracted from white NF-grade beeswax (GRAS)Patent granted to supplier in October (for use, composition and process)Pharmanex has been granted exclusivity for Network Marketing Channel†Policor is a trademark of Hauser, Inc.
9PoliSorb™ † Proprietary Delivery PoliSorb softgels have over 10 times better dissolution than policosanol capsules or tabletsPolicosanol delivery can be problematic:naturally a fat-soluble, waxy substanceremains solid at body temperaturetablets & capsules have poor dissolutionPharmanex PoliSorb™ proprietary delivery:overcomes solubility problemsemulsified with lecithin phospholipidsnatural cell membrane components†Policor is a trademark of Hauser, Inc.
10Policosanol: Clinical Data Policosanol (sugar cane wax), double-blind clinical trials:**Blood lipids: 13 studies (total of 1,378 subjects)Platelet aggregation: 6 studiesLDL-oxidation: 1 studyPolicosanol from beeswax may be more effective:Main constituent in sugar cane wax, octacosanol, is not very active in rats (Kato S, Br J Nutr 1995;73:433)Beeswax policosanol clinical trials:Two open-label pilot studies* Summarized in Healthcare Professionals Product Guide
11Clinical Data - Summary Research with policosanol has shown the following results (10-20 mg/day):*Benefits after 8-12 weeks, maximum effect evident after 12 monthsExcellent safety & side effect profile* Summarized in Healthcare Professionals Product Guide
12Policosanol Safety Beeswax policosanol has excellent safety data: Clinical data: few & mild side effects*Made from purified, white NF-grade beeswaxGRAS (FDA-Approved) for food & drug use* Summarized in Healthcare Professionals Product Guide
13Drug Interactions No clinical reports of drug interactions* Preliminary contraindications:high-dose aspirin therapyanticoagulants (warfarin, coumadin, etc.)discontinue within 2 weeks of surgery* Summarized in Healthcare Professionals Product Guide
14Summary Cholestin maintains existing normal cholesterol levels* Provides 15 mg per softgel of policosanolPolicosanol is clinically provenProprietary PoliSorb™ softgel deliveryConvenient once-a-day dosageSafe & well toleratedPharmanex is first to market in the USPharmanex has exclusive rights for the network marketing channel* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.