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Cholestin ® Product Training Series This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities.

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Presentation on theme: "Cholestin ® Product Training Series This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities."— Presentation transcript:

1 Cholestin ® Product Training Series This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.

2 New & Improved Cholestin ® Cholestin contains policosanol, a novel ingredient extracted from beeswax Policosanol is clinically proven* –safe, effective, and well-tolerated Proprietary PoliSorb™ † softgel delivery Convenient once-a-day dosage Pharmanex is first to market in the US Pharmanex has exclusive rights for the network marketing channel †Policor is a trademark of Hauser, Inc.

3 NCEP Cholesterol Guidelines From: Third report of the National Cholesterol Education Program Expert Panel, May 2001

4 NCEP Cholesterol Guidelines Using NCEP guidelines, about 65 million Americans should make dietary and lifestyle changes to maintain cardiovascular health

5 Cholestin ® : Health Benefits Maintains existing normal cholesterol levels* –Total & LDL-Cholesterol –HDL-Cholesterol –LDL/HDL Ratio –Triglycerides Helps prevent oxidation of LDL cholesterol* Promotes normal blood fluidity* * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

6 History of Policosanol Early 90’s: Beeswax policosanol initially sourced in Cuba Mid 90’s: Sugar cane policosanol suggested as more economical source Cuban government Sugarcane policosanol clinically tested and commercialized in Cuba Pedro P. Perez revives R&D work in US for beeswax policosanol Perez teams up with top-quality pharmaceutical company; now supplier 2001: Pharmanex launches Cholestin ® - beeswax policosanol

7 Cholestin Composition Primary Active Constituent: Policosanol from Beeswax (Policor TM ) † –Novel ingredient - “Cholesterol Breakthrough” –Extracted from white NF-grade beeswax (GRAS) –Patent granted to supplier in October 2001 (for use, composition and process) Pharmanex has been granted exclusivity for Network Marketing Channel †Policor is a trademark of Hauser, Inc.

8 Standardization Guaranteed minimum 40% policosanol Reproducible fingerprint of 5 primary aliphatic long- chain alcohols

9 PoliSorb™ † Proprietary Delivery Policosanol delivery can be problematic: –naturally a fat-soluble, waxy substance –remains solid at body temperature –tablets & capsules have poor dissolution Pharmanex PoliSorb™ proprietary delivery: –overcomes solubility problems –emulsified with lecithin phospholipids natural cell membrane components PoliSorb softgels have over 10 times better dissolution than policosanol capsules or tablets †Policor is a trademark of Hauser, Inc.

10 Policosanol: Clinical Data Policosanol (sugar cane wax), double-blind clinical trials:** Blood lipids: 13 studies (total of 1,378 subjects) Platelet aggregation: 6 studies LDL-oxidation: 1 study Policosanol from beeswax may be more effective: Main constituent in sugar cane wax, octacosanol, is not very active in rats (Kato S, Br J Nutr 1995;73:433) Beeswax policosanol clinical trials: Two open-label pilot studies * Summarized in Healthcare Professionals Product Guide

11 Clinical Data - Summary Research with policosanol has shown the following results (10-20 mg/day):* Benefits after 8-12 weeks, maximum effect evident after 12 months Excellent safety & side effect profile * Summarized in Healthcare Professionals Product Guide

12 Policosanol Safety Beeswax policosanol has excellent safety data: Clinical data: few & mild side effects* Made from purified, white NF-grade beeswax GRAS (FDA-Approved) for food & drug use * Summarized in Healthcare Professionals Product Guide

13 Drug Interactions No clinical reports of drug interactions* Preliminary contraindications: –high-dose aspirin therapy –anticoagulants (warfarin, coumadin, etc.) –discontinue within 2 weeks of surgery * Summarized in Healthcare Professionals Product Guide

14 Summary Cholestin maintains existing normal cholesterol levels* Provides 15 mg per softgel of policosanol Policosanol is clinically proven Proprietary PoliSorb™ softgel delivery Convenient once-a-day dosage Safe & well tolerated Pharmanex is first to market in the US Pharmanex has exclusive rights for the network marketing channel * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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