1. 30
Animal Hormones

2. Chapter 30 Animal Hormones
Key Concepts
30.1 Hormones Are Chemical Messengers
30.2 Hormones Act by Binding to Receptors
30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
30.4 Hormones Regulate Mammalian Physiological Systems

3. Chapter 30 Opening Question
How do the transformative effects of testosterone exemplify the way many hormones work?

4. Concept 30.1 Hormones Are Chemical Messengers
Endocrine secretion—cells secrete substances into the extracellular fluid
Exocrine secretion—cells secrete substances into a duct or a body cavity that communicates to the external world

5. Concept 30.1 Hormones Are Chemical Messengers
Endocrine cells—cells that secrete endocrine signals
Some endocrine cells exist as single cells (e.g., in the digestive tract).
Endocrine glands—secretory organs composed of aggregations of endocrine cells

6. Concept 30.1 Hormones Are Chemical Messengers
Endocrine signaling molecules are paracrine signals, autocrine signals, or hormones.
Hormones are “long-distance” endocrine signals that are released into the bloodstream and circulate throughout the body.
See Chapter 5
See Figure 5.10

7. Concept 30.1 Hormones Are Chemical Messengers
Target cells—cells that have receptors for the chemical signals
The same hormone can have a variety of different target cells, all distant from the site of release.

8. Concept 30.1 Hormones Are Chemical Messengers
Hormones are in three chemical groups:
Peptide and protein hormones—water- soluble, transported in blood with receptors on exterior of target cells
Steroid hormones—synthesized from cholesterol; lipid-soluble; bound to carrier proteins in blood; receptors inside target cells
VIDEO 30.1 Cell Visualization: Membranes, hormones, and receptors
VIDEO 30.2 Cell Visualization: Signals and calcium

9. Concept 30.1 Hormones Are Chemical Messengers
Amine hormones—synthesized from single amino acids; may be lipid-soluble or water-soluble, depending on the charge of the amino acid

10. Figure 30.1 Three Classes of Hormones (Part 1)

11. Figure 30.1 Three Classes of Hormones (Part 2)

12. Figure 30.1 Three Classes of Hormones (Part 3)

13. Concept 30.1 Hormones Are Chemical Messengers
Chemical communication was critical for evolution of multicellular organisms.
Plants, sponges, and protists all use chemical signals.
Signaling molecules are highly conserved, but their functions differ.
LINK The study of plant growth and development has contributed greatly to our knowledge of hormones and how they work; see Chapter 26

14. Concept 30.1 Hormones Are Chemical Messengers
In arthropods, hormones control molting and metamorphosis
The rigid exoskeleton is shed during molts to allow growth.
Growth stages between molts are called instars.

15. Figure 30.2 A Diffusible Substance Triggers Molting (Part 1)

16. Figure 30.2 A Diffusible Substance Triggers Molting (Part 2)

17. Concept 30.1 Hormones Are Chemical Messengers
Two hormones regulate molting:
PTTH (prothoracicotropic hormone), from cells in the brain, is stored in the corpora cardiaca
PTTH stimulates the prothoracic gland to secrete ecdysone.
Ecdysone diffuses to target tissues and stimulates molting.

18. Concept 30.1 Hormones Are Chemical Messengers
A third hormone, juvenile hormone, is also released from the brain—prevents maturation to adult form.
Control of development by juvenile hormone is important in insects with complete metamorphosis.
ANIMATED TUTORIAL 30.1 Complete Metamorphosis
VIDEO 30.3 Complete metamorphosis in a butterfly

19. Figure 30.3 Hormonal Control of Metamorphosis

20. Concept 30.2 Hormones Act by Binding to Receptors
Hormone receptors can be membrane- bound with three domains:
Binding domain—projects outside plasma membrane
Transmembrane domain—anchors receptor
Cytoplasmic domain—extends into cytoplasm, initiates target cell response
LINK Review the mechanisms of receptor protein actions in Concepts 5.5 and 5.6
See Figure 5.17

21. Concept 30.2 Hormones Act by Binding to Receptors
Hormone receptors can also be intracellular:
Lipid soluble hormones—receptors are inside the cell, usually in the cytoplasm
When hormone binds, the hormone– receptor complex moves into the nucleus.
See Concept 36.1

22. Concept 30.2 Hormones Act by Binding to Receptors
One hormone can trigger different responses in different types of cells.
Epinephrine and norepinephrine are secreted by adrenal glands in the fight-or- flight response.
These hormones bind to adrenergic receptors.
See Concept 5.5
VIDEO 30.4 Human physiological response to adrenaline

23. Figure 30.4 The Fight-or-Flight Response

24. Concept 30.2 Hormones Act by Binding to Receptors
Two categories: -adrenergic and - adrenergic receptors
Stimulation of one receptor can cause diverse effects, depending on its location.
Example: -adrenergic stimulation causes sweating in skin and shutdown of digestive enzymes and decreased blood flow in gut.
See Chapter 39

25. Figure 30.5 Adrenergic Receptors (Part 1)

26. Figure 30.5 Adrenergic Receptors (Part 2)

27. Concept 30.2 Hormones Act by Binding to Receptors
Abundance of hormone receptors can be regulated by negative feedback.
Downregulation—continuous high level of hormone decreases number of receptors.
Upregulation—when hormone secretion is suppressed, receptors increase.
LINK The crucial role of insulin in regulating glucose metabolism is detailed in Concept 39.4

28. Figure 30.6 The Human Endocrine System

29. The nervous system communicates via molecules—neurotransmitters.
Concept 30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
The nervous system communicates via molecules—neurotransmitters.
The endocrine system communicates via molecules released into the blood.
The systems are complementary—nervous system is rapid and specific, endocrine system is broader and longer-term.

30. The nervous and endocrine systems also interact.
Concept 30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
The nervous and endocrine systems also interact.
Nervous system controls activity of many endocrine glands.
Some neurons secrete hormones directly— neurohormones.
Endocrine system can also influence the nervous system—steroids promote sexual behavior.
ANIMATED TUTORIAL 30.2 The Hypothalamus-Pituitary-Endocrine Axis

31. The pituitary gland connects the nervous and endocrine systems.
Concept 30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
The pituitary gland connects the nervous and endocrine systems.
The pituitary gland is attached to the hypothalamus of the brain.
Two parts—the anterior pituitary and posterior pituitary

32. Figure 30.7 The Posterior Pituitary (Part 1)

33. Concept 30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
The hypothalamus secretes two neurohormones into the posterior pituitary: antidiuretic hormone (vasopressin) and oxytocin.
Antidiuretic hormone (ADH) serves to increase the water retained by the kidneys when necessary.
Oxytocin stimulates contractions, milk flow, promotes bonding—the “cuddle chemical”

34. Figure 30.7 The Posterior Pituitary (Part 2)

35. Thyroid-stimulating hormone (TSH) Luteinizing hormone (LH)
Concept 30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
The anterior pituitary secretes four tropic hormones that control other endocrine glands:
Thyroid-stimulating hormone (TSH)
Luteinizing hormone (LH)
Follicle-stimulating hormone (FSH)
Adrenocorticotropin hormone (ACTH)

36. Figure 30.8 The Anterior Pituitary

37. Growth hormone (GH) stimulates cells to take up amino acids.
Concept 30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
The anterior pituitary also secretes other peptide hormones including prolactin and growth hormone.
Growth hormone (GH) stimulates cells to take up amino acids.
GH stimulates the liver to produce somatomedins or insulin-like growth factors (IGFs).
Overproduction of GH causes gigantism; underproduction causes pituitary dwarfism.
See pp. 604–605

38. Concept 30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
Neurohormones from the hypothalamus control subsequent hormone production in the anterior pituitary.
The hypothalamus sends secretions to the anterior pituitary via the portal blood vessels.

39. TSH causes the thyroid gland to release thyroxine.
Concept 30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
Hypothalamic neurohormones are released in minute quantities measurable by immunoassay.
The first releasing hormone to be purified was thyrotropin-releasing hormone (TRH).
TRH causes anterior pituitary cells to release thyroid-stimulating hormone (TSH).
TSH causes the thyroid gland to release thyroxine.
See p. 614
See Chapter 31

40. Hypothalamus slows release of corticotropin-releasing hormone.
Concept 30.3 The Pituitary Gland Links the Nervous and Endocrine Systems
Negative feedback loops control hormone secretion from the anterior pituitary.
Corticotropin is released by pituitary— adrenal produces cortisol in response.
Circulating cortisol in bloodstream reaches pituitary and inhibits production.
Hypothalamus slows release of corticotropin-releasing hormone.
APPLY THE CONCEPT The pituitary gland links the nervous and endocrine systems

41. Figure 30.9 Multiple Feedback Loops Control Hormone Secretion

42. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
The thyroid gland contains two cell types that produce two different hormones, thyroxine and calcitonin.
In or near the thyroid gland are the parathyroid glands, which produce parathyroid hormone.
Thyroxine (T4) is synthesized from the amino acid tyrosine and iodine.
T3 is a similar hormone that is more active.

43. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
In birds and mammals, thyroxine raises metabolic rate.
Thyroxine regulates cell metabolism by acting as a transcription factor for many genes and is crucial during development.
Hypothalamus releases thyrotropin- releasing hormone (TRH), which causes anterior pituitary to secrete thyroid- stimulating hormone (TSH).
TSH causes the thyroid to produce thyroxine.

44. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Goiter is an enlarged thyroid gland.
Hyperthyroidism (thyroxine excess) is often caused by an autoimmune disease.
Antibody-binding activates TSH receptors on follicle cells and increases thyroxine.
Thyroid remains stimulated and grows bigger.

45. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Hypothyroidism (thyroxine deficiency) is the result of low circulating thyroxine.
The most common cause is iodine deficiency—thyroid cannot produce thyroxine.
TSH levels remain high and stimulate the thyroid to grow bigger.

46. Figure Goiter

47. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Blood calcium concentration is controlled by calcitonin, calcitriol (from vitamin D), and parathyroid hormone (PTH).
Mechanisms for changing calcium levels:
Deposition or absorption by bone
Excretion or retention by kidneys
Absorption of calcium from digestive tract

48. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Calcitonin, released by thyroid, lowers blood calcium (Ca2+) by regulating bone turnover.
Osteoclasts break down bone, increasing blood Ca2+.
Ca2+ is deposited into bone by osteoblasts; levels of Ca2+ in blood decrease.
Calcitonin decreases osteoclast activity and favors adding calcium to bones.

49. Figure 30.11 Hormonal Regulation of Calcium

50. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Vitamin D (calciferol) is synthesized from cholesterol in skin cells by UV light.
Once synthesized it is converted to calcitriol, a hormone that stimulates calcium absorption from food.
If light is insufficient, vitamin D must be obtained from diet or supplements.
ANIMATED TUTORIAL 30.3 Hormonal Regulation of Calcium

51. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
The parathyroid glands secrete parathyroid hormone (PTH).
PTH raises blood calcium levels:
Stimulates osteoclasts and osteoblasts
Stimulates kidneys to reabsorb calcium
Activates synthesis of calcitriol from vitamin D
APPLY THE CONCEPT Hormones regulate mammalian physiological systems

52. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Each of the two adrenal glands is a gland within a gland.
The core, or adrenal medulla, produces epinephrine and norepinephrine.
Release of these neurohormones is under control of the nervous system and is very rapid in the stress response.

53. Figure 30.12 The Adrenal Is a Gland within a Gland

54. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
The outer adrenal cortex produces two types of corticosteroid hormones:
Mineralocorticoids influence salt and water balance
Aldosterone, the main mineralocorticoid, stimulates kidneys to conserve sodium and excrete potassium.

55. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Glucocorticoids influence blood glucose concentration
Cortisol, the main glucocorticoid in humans and mammals, mediates metabolic stress response.
After a stressful stimulus, blood cortisol rises.
Cells not critical for action decrease their use of blood glucose—immune system reactions are also blocked.

56. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Gonads produce sex steroids.
Androgens—male steroids, testosterone
Estrogens and progesterone—female steroids
Both sexes use both types, in varying levels.
In embryos, sex hormones determine sex of fetus; at puberty, they stimulate maturation and secondary sex characteristics.

57. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Sex hormones exert their effects by the seventh week of human development.
If a Y chromosome is present, gonads begin producing testosterone and MIS (Müllerian-inhibiting substance)—these produce male reproductive organs and inhibit female reproductive structures.
Without androgens, female reproductive structures develop.

58. Figure 30.13 Sex Steroids Direct the Development of Human Sex Organs (Part 1)

59. Figure 30.13 Sex Steroids Direct the Development of Human Sex Organs (Part 2)

60. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
At puberty, production of sex hormones increases.
Controlled by tropic hormones called gonadotropins from the anterior pituitary:
Luteinizing hormone (LH)
Follicle-stimulating hormone (FSH)

61. Concept 30.4 Hormones Regulate Mammalian Physiological Systems
Gonadotropins are controlled by hypothalamic gonadotropin-releasing hormone (GnrH)—its release increases at puberty.
Increase in gonadotropins leads to increase in sex steroids and development of secondary sex characteristics.

62. Answer to Opening Question
Hormones and their receptor complexes can have varying effects depending on the type of target cells. The receptors are essential because without them the circulating hormones are unable to have the desired effect. Hormones may also be modified during development, with different effects at different stages.

63. Figure 30.14 Real People, Real Lives