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The tRNA molecule tRNA molecules do the final translating At one end the have a specific amino acid attached by a tRNA activating enzyme These enzymes do the first part of translating At the other end they have an anticodon which is complementary to the mRNA codons © St Edward’s University: Dept Chemistry and Biochemistry © 2007 Paul Billiet ODWSODWS
1 st position 2 nd position 3 rd position ↓ UCAG U PheSerTyrCys U PheSerTyrCys C LeuSerSTOP A LeuSerSTOPTrp G C LeuProHisArg U LeuProHisArg C LeuProGlnArg A LeuProGlnArg G A IleThrAsnSer U IleThrAsnSer C IleThrLysArg A MetThrLysArg G G ValAlaAspGly U ValAlaAspGly C ValAlaGluGly A ValAlaGluGly G AcidicBasicUncharged PolarNon-polar © 2007 Paul Billiet ODWS
Translation1 AUGGGAUACACUUUUUGA mRNA Ribosome © 2007 Paul Billiet ODWSODWS
Translation 2 AUGGGAUACACUUUUUGA met UAC tRNA amino acid anticodon © 2007 Paul Billiet ODWSODWS
Translation 3 CCU gly AUGGGAUACACUUUUUGA UAC met © 2007 Paul Billiet ODWSODWS
Translation 4 AUGGGAUACACUUUUUGA CCU gly UAC met peptide bond © 2007 Paul Billiet ODWSODWS
Translation 5 UAC AUGGGAUACACUUUUUGA CCU glymet AUG tyr © 2007 Paul Billiet ODWSODWS
Translation 6 AUGGGAUACACUUUUUGA CCUAUG glymettyr © 2007 Paul Billiet ODWSODWS
Translation 7 UGA thr CCU AUGGGAUACACUUUUUGA AUG glymettyr © 2007 Paul Billiet ODWSODWS
Translation 8 AAA phe AUGGGAUACACUUUUUGA AUG UGA glymettyr thr polypeptide chain © 2007 Paul Billiet ODWSODWS
Translation: the sequence The tRNA molecules with the correct anticodons are lined up with their bases complementary to the mRNA codons Two tRNA molecules at a time can fit on the ribosome A peptide bond forms between their amino acids The first tRNA leaves the ribosome and mRNA move along to accept a new tRNA The process of translation proceeds in the same direction as replication and transcription (5’ to 3’) © 2007 Paul Billiet ODWSODWS
Translation © 2007 Paul Billiet ODWSODWS. The tRNA molecule tRNA molecules do the final translating At one end the have a specific amino acid attached.
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