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By N.S.Venkatesh, T.John college of pharmacy, Bengaluru. 1.

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Presentation on theme: "By N.S.Venkatesh, T.John college of pharmacy, Bengaluru. 1."— Presentation transcript:

1 By N.S.Venkatesh, T.John college of pharmacy, Bengaluru. 1

2  Richard Feynman ( ).  Physicist.  Shared Nobel Prize in 1965 for “Quantum electrodynamics” “There’s plenty of room at the bottom” 2

3 Nano in greek means “dwarfs” Nanotechnology is the ‘engineering of functional systems at the nanoscale’ (atomic, molecular, macromolecular). 3

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6  Human hair = 20,000 nm; can carry 1 lakh nanoparticle.  Whole population……you & me is Nano.  A small marble piece in earth.  2 Sec ……. 1 nm growth of beard.  10 hydrogen atoms= 1 nm. 6

7  Top-down Approach………. Tera to Atto Or (10 12 to ).  Bottom-up Approach.…….. Atto to Micro Or ( to ) 7

8  Nanoparticle ……. gold, silver, platinum, iron.  Nanofilaments …… silicone, wrinkle proof cloth.  Nanotubes ………… carbon tubes.  Nanofilms …………. graphenes 8

9  Physical Method: Ball mill, Laser...etc  Chemical Method: (i) Metal Salt + Alcohol / Reducing agent. (ii) Metals (oxides)+reagents+water.....heated-up in a closed vessel……nano particle. 9

10 10 1.Homogenizer 2.Ultra Sonicator 3.Mills 4.Spray Milling 5.Supercritical Fluid Technology 6.Electrospray 7.Ultracentrifugation 8.Nanofiltration

11 11  Solution of Dextran + Ferric hexahydrate (acidic solution)  Drip in Ammonium hydroxide (basic) at ~2 o C  Stirred at 75 o C for 75 min.  Purified by washing and ultra-centrifugation  Resulting Size ~ nm  Plasma half-life: 200 min

12 1. Passive nanostructure:- Aerosols. (2000) 2. Active nanostructure:- Targeted drugs.(2005) 3. Systems of nano:- Robotics. (2010) 4. Molecular nanosystem:- Atomic design, Military camera ( ) 12

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14 1. Nanocosmetics…… Nanosome skin cream. 2.Nanotextiles……. Lotus leaves, PTFE. 3.Nanosensors……. Dog, Dolphin, Tsunami. 4.Drug delivery…….. BBB. 5.Tissue engineering…. Tissue transplantations. 6.Lap on a chip (LOP)…. ABG, Glucometer. 7.CNT display….. Aspect ratio, Clarity, Long lasting 8.Nanocomputers…… DNA Storage. 14

15 1.Silver nanoparticle…… Aquaguard, Socks. 2.LED …. Gallium nitride Nano+Yellow Phosphorus. 3.MRI……… increase brightness of the image. 4.Carbon black….. paint, wear resistance tyres,polish,hard disk,sunscreen lotions (titania). 5.Diagnosis of disease….. CdSe. 6.Damascus Sword….. nanotubes,nanowires. 15

16 16  Development of one dose a day ciprofloxacin using nanotechnology.  Tumor targeted taxol delivery using nanoparticles in Phase 2 clinical trial stage.  Improved ophthalmic delivery formulation using smart hydrogel nanoparticles.  Oral insulin formulation using nanoparticles carriers.  Liposomal based Amphotericin B formulation.

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18  Graphenes:- A Single layer of carbon atoms arranged in a hexagonal lattice graphite structure. (gas detection, IC)  7 million= 1mm, elephant 18

19  Carbon Nano Tubes (CNT):- Cylindrical graphenes.(Entering nuclei of the cell to deliver drugs, TV Displays) 19

20  Buckyballs:- Spherical fullerenes (any molecule entirely composed of Carbon)  Allotropes:- Two or more different physical forms in which an element can present.(diamond, graphite,charcoal) 20

21  Scaffolds:- Artificial,3D, biodegradable, biocompatible, temporary structure. (Transplantation) 21

22  Diagnosis :- CdSe IV seep into tumor under uv light cancer cell glows.  Cancer Treatment :- Gold nanoparticle + cancer cell Radiation Metal(gold) absorbs energy(heat) Heat up cancer cell cancer cells are cooked inside the body, but healthy cells remain unaffected.  Another MOA:- Increased heat Increase hsp90 Up- regulation Increase anti-cancer activity. (By nanotube & nanofibers, peptide inserted into fibroblast)  Fibroblast secretes IF alpha 22

23  Gold nanorods coated with bombesin attach to GRP receptors and are taken into the cancer cell. NIR laser energy is absorbed by the gold and kills the cell with heat. Gold permits imaging of the process. 23

24 Core Research Areas/ Team Leadership Bio Sensors Drug Delivery Systems Cellular Probes Core Research Areas Tissue Engineering 24

25 For cancer, the very exciting promises that should be realized over the next 10 years are: 1. Presymptomatic blood diagnoses 2. Targeted Medicine (For breast & prostate Cancer) “This new approach to medicine may help us to have healthy & virtual life style” 25

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