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The Complement Cascade The Classical Pathway Next
Complement: The Classical Pathway AgAb Antibody binds to antigen C1q C1q binds to antibody/antigen complex Next
Complement: The Classical Pathway C1q-Ab-Ag
Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1q/antibody/antigen complex activates C1r (bound to C1s) Next
Activated C1r cleaves C1r/C1s, Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s releasing Active C1s C1s Next
Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C1s cleaves C4 to C4a and C4b C4a C4b Next
Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4b binds to C2 C4b C4a C2 C4b.2 Next
Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2 C4b.2b C2a producing C4b.2b and C2a Next C1s cleaves C2
Complement: The Classical Pathway C4b.2b is termed the Classical C3 Convertase C4b.2b cleaves C3 to produce C3b (C3a is released) C3b is the first molecule of the Terminal Pathway Next
Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2C4b.2b C2a C3 C3a C3b producing C3a and C3b Cb4.2b cleaves C3 (Click Here)
Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2b C2a C3 C3a C3b C5C5b C5a C4b.2
Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2b C2a C3 C3a C3b C5C5b C5a C4b.2 C6 C5b.6 C7 C5b.6.7 C8 C5b.6.7.8 C9n C5b.184.108.40.206n
The Complement Cascade The Terminal Pathway. Complement: The Terminal Pathway C3b C3b is the first component of the Terminal Pathway C3a C3.
The Complement system. The complement system A defensive system consisting of over 30 proteins produced by the liver and found in circulating blood serum.
Principles of Immunology Complement 2/7/06 “Nothing is to be more prized than the value of each day” Goethe.
The Complement System Amy Lovett-Racke, PhD Associate Professor Department of Microbial Infection and Immunity Reading: The Immune System, 3 rd Edition,
X Complement A group of serum proteins that activates each other in an orderly fashion to generate biologically active molecules. Like enzymes, opsonins.
Complement system references C was discovered several years ago as a heat labile of normal plasma that augment opsonozation of bacteria by Ab.coplement.
Overview of Immunology  Organs and tissues  Cells  Molecules － Antibodies  － Complement  － Cytokines  － MHC molecules  Antigen (Ag)
Complement Jan 25, Complement (C’) Complement Complement refers, historically, to fresh serum capable of lysing antibody (Ab)-coated cells. This.
Antigenic Surface C1r and C1s Enzymes Associate with C1q to form C1 CH 2 Conformational Change C1r 2 - C1s 2 C1q Ca 2+ Fig. 9.1 C1 activation by an antibody.
THE COMPLEMENT SYSTEM. The complement system The complement system is a set of plasma proteins that act in a cascade to attack and kill extracellular.
1. Complement System 2. Antigen Specific Receptors K.J. Goodrum Department of Biomedical Sciences 2005.
The overview…. Complement has three functions: –Opsonin –Chemoattractant –Membrane Attack Complex (MAC) Complement functions in two (three?) systems:
Humoral Immunity and Complement Robert Beatty MCB150.
1 Antigens combine with antibodies to form antigen- antibody complexes Antigen Antibody Antigen-antibody complex.
The Complement System. Historical Background Pfeiffer:- Lysis of Cholera bacilli - Demonstration of heat liability Bordet: Confirmed the observations.
Dental Microbiology #211 IMMUNOLOGY 2006 Lecture 4 The Antibodies and the Complement System.
Complement Synthesis and attachment of specific antibody to invading microorganisms does not directly lead to destruction. It is a "label" that.
The Complement system. objectives Factors involved in the immune response The complement system General properties of complement Cascade activation complement.
Innate Defenses Complement The complement system is a biochemical cascade that helps clear pathogens from an organism It is part of the innate immune system.
COMPLEMENT SYSTEM Elainne Kesuma ( ) Harvianto Siman Santosa ( ) Photo Courtesy: Widhi Nugraha Sutedjo.
114/14/2015 Complement Hugh B. Fackrell & Maria Sawicki.
Chapter 2. Innate immunity. The response to an initial infection Figure Innate immunity - Early induced response - Adaptive immune response.
Effector mechanisms of humoral immunity The Complement System (C’) Activation pathways Effector functions Regulation of complement activation.
The Complement System A group of > 30 plasma proteins which comprise the primary soluble component of innate immunity. Rapidly activated in response to.
THE COMPLEMENT SYSTEM. Help! COMPLEMENT A group of sequentially reacting proteins, which upon activation, mediate a number of biological reactions important.
The complement system is a biochemical cascade that helps, or “complements”, the ability of antibodies to clear pathogens from an organism. It is part.
CHAPTER12 Immune Response to Biomaterials 12-1 Introduction: Overview of Acquired Immunity Innate immunity vs. Acquired immunity Immunotoxicity: adverse.
Chapter 17 Immunoregulation. To keep the individual homeostasis by regulating the balance between immunocyte and immunocyte, between immunocyte and immune.
AB 11 22 33 44 55 66 77 88 99 10 20 19 18 17 16 15 14 13 12 11 21 22 23 24 25 26 27 28.
Complement. Innate Immunity Defensive mechanisms include : 1) Innate immunity (Natural or Non specific) 2) Acquired immunity (Adaptive or Specific ) Cell-mediated.
Blood Type Warmup 1)Which blood type only has Rh antigens? 2)Which blood type only has B antigens? 3)Which blood type only has Rh antibodies? 4)Which blood.
Compl e ment What is “it”? A series of serum proteins. How is it recognized? By its ability to mediate cell lysis. (Review the fascinating story of.
ALLAH does not want from you to be the BEST ALLAH wants from you to do your BEST ALLAH will take care of the REST.
Chapter 6 Complement. The end of 19 century Jules Bordet ( ) Chapter 6 Complement.
Antigen presentation to T cells Zheng W. Chen, M.D., Ph.D.
BIOT 307 MOLECULAR IMMUNOLOGY INNATE IMMUNITY External – Skin – Epidermis and dermis are protective layers – Other protectants pH ~ 3-5 b/c of sebum.
Functions of Complement A. Host Defense B. Disposal of Waste C. Regulation of the Immune Response.
Chemical Mediators 2 Dr. Hiba Wazeer Al Zou’bi. Complement Activation Pathways 2.
HUMORAL IMMUNITY Primary molecular component: antibody Ab is made by B-cells and plasma cells in response to Ag challenge Ab: protection vs rechallenge.
Innate Immunity1 Self-Test Questions: A: both B1: all B2-3: 1 - 6, 9 B4: B5: B6: 1 Review on your own: Clathrin-mediated endocytosis Endomembrane.
Immunology (elective) MLIM-101 Prepared by: Dr. Mohamed S. Abdel-Latif.
PRINCIPLES OF INNATE IMMUNITY. THE INNATE IMMUNE SYSTEM *First line of defense against pathogens *Components *Complement system *Macrophages and neutrophils.
“A fascinating and personal portrait of the immune system. In Callahan’s picture, it’s the immune system, not our brains that defines our humanity.”
Chapter 6 Complement. Section I introduction Discovery of complement The end of 19 century Jules Bordent ( ),
2. Basic Immunologic Procedures Terry Kotrla, MS, MT(ASCP)BB.
Complement Dr. Mona Badr Assistant Professor King Saud University.
Innate Immunity. Mechanisms that do not depend on prior exposure to the pathogen Have evolved over time to protect against groups of organisms that.
Complement functions Host benefit: –opsonization to enhance phagocytosis –phagocyte attraction and activation –lysis of bacteria and infected cells –regulation.
Principles of Immunology Antigen-Antibody Interactions 4/25/06.
Complement J. Ochotná. Complement system of about 30 serum and membrane proteins (humoral component of nonspecific immunity) complement components.
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