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The Complement Cascade The Classical Pathway Next

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Complement: The Classical Pathway AgAb Antibody binds to antigen C1q C1q binds to antibody/antigen complex Next

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Complement: The Classical Pathway C1q-Ab-Ag

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Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1q/antibody/antigen complex activates C1r (bound to C1s) Next

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Activated C1r cleaves C1r/C1s, Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s releasing Active C1s C1s Next

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Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C1s cleaves C4 to C4a and C4b C4a C4b Next

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Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4b binds to C2 C4b C4a C2 C4b.2 Next

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Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2 C4b.2b C2a producing C4b.2b and C2a Next C1s cleaves C2

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Complement: The Classical Pathway C4b.2b is termed the Classical C3 Convertase C4b.2b cleaves C3 to produce C3b (C3a is released) C3b is the first molecule of the Terminal Pathway Next

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Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2C4b.2b C2a C3 C3a C3b producing C3a and C3b Cb4.2b cleaves C3 (Click Here)

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Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2b C2a C3 C3a C3b C5C5b C5a C4b.2

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Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2b C2a C3 C3a C3b C5C5b C5a C4b.2 C6 C5b.6 C7 C5b.6.7 C8 C5b C9n C5b n

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