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The Complement Cascade The Classical Pathway Next.

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Presentation on theme: "The Complement Cascade The Classical Pathway Next."— Presentation transcript:

1 The Complement Cascade The Classical Pathway Next

2 Complement: The Classical Pathway AgAb Antibody binds to antigen C1q C1q binds to antibody/antigen complex Next

3 Complement: The Classical Pathway C1q-Ab-Ag

4 Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1q/antibody/antigen complex activates C1r (bound to C1s) Next

5 Activated C1r cleaves C1r/C1s, Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s releasing Active C1s C1s Next

6 Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C1s cleaves C4 to C4a and C4b C4a C4b Next

7 Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4b binds to C2 C4b C4a C2 C4b.2 Next

8 Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2 C4b.2b C2a producing C4b.2b and C2a Next C1s cleaves C2

9 Complement: The Classical Pathway C4b.2b is termed the Classical C3 Convertase C4b.2b cleaves C3 to produce C3b (C3a is released) C3b is the first molecule of the Terminal Pathway Next

10 Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2C4b.2b C2a C3 C3a C3b producing C3a and C3b Cb4.2b cleaves C3 (Click Here)

11 Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2b C2a C3 C3a C3b C5C5b C5a C4b.2

12 Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1r-C1s C1s C4 C4a C4b.2b C2a C3 C3a C3b C5C5b C5a C4b.2 C6 C5b.6 C7 C5b.6.7 C8 C5b C9n C5b n


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