64 4/14/2015 Key Terms l alternative pathway anaphyltoxin inactivator anaphylatoxins l C1 C1q C1r C1s l C1 inhibitor (C1-INH), C2 C2a C2b l C3 C3a C3b C3 convertase l C3b/C4b receptor(CR1) C4 C4a 4b l C4 binding protein (C4-bp)
65 4/14/2015 l C5 C5a C5b C5 convertase l C6 C7 C8 C9 CD59 l classical pathway amplification phase activation phase membrane attack phase l complement complement system l Factor B Factor D Factor H Factor I
66 4/14/2015 l immune adherence membrane attack complex(MAC) opsonization l properdin S protein
67 4/14/2015 Key Concepts l Describe the nomenclature of complement components l Draw a concept map of the classical complement cascade l Draw a concept map of the alternate pathway of complement activation l Describe with specific examples the regulation of complement activation
68 4/14/2015 l Discuss why the amplification phase in critical to many immune reactions. l Specify the major sources of complement and comment on the genetic control of complemt proteins
70 4/14/2015 l Complement is involved in antigen- antibody interactions, yet there is no agglutination or precipitation. What does happen? l What are the important functions of complement?
71 4/14/2015 l Differentiate between the classical pathway and the alternate pathway of complement activation l Briefly discuss the three stages of the classical pathway of complement activation. What stage is the most important? Why?
72 4/14/2015 l What is the difference between complement activation by antigen-IgM complexes and antigen-IgG complexes? l What is the biologic importance of C4a? l What complement components make up C3 convertase and what does it do?
73 4/14/2015 l Macrophages have receptors for C3b. What is the biologic significance of this fact? l What is the last complement component to be split into two biologically active fragments? What are their functions?
74 4/14/2015 l If the complement cascade is stopped before the membrane attack phase, has complement fulfilled its function in an immune response? –If Yes, Why? –If No? Speculate on the reason for having the membrane attack phase?
75 4/14/2015 l What components of the complement system are shared between the classical pathway and the alternative pathway? l Why is it important to tightly control complement activation?