Presentation on theme: "Vision To be an internationally leading center that develops, uses and provides access to advanced technologies for molecular biosciences with focus on."— Presentation transcript:
4 BoardProfessor Göran Sandberg, Government appointed Chair, Executive Director, Knut and Alice Wallenberg FoundationMargareta Olsson Birgersson, Government appointed Industry representative, Medical Director, Roche SwedenProfessor Sophia Hober, Dean of Faculty, KTH Royal Institute of TechnologyStellan Sandler, Pro Vice-Chancellor, Uppsala UniversityProfessor Hans Adolfsson, Pro Vice-Chancellor, Stockholm UniversityProfessor Hans-Gustaf Ljunggren, Dean of Research, Karolinska InstitutetProfessor Maria Anvret, Senior Advisor, University of GothenburgProfessor Gunilla Westergren-Thorsson, Dean of Faculty of Medicine, Lund UniversityProfessor Karl-Eric Magnusson, Linköping University
5 National Reference Committee Karl-Eric Magnusson (Linköping University)Anders Malmström (Lund University)Göran Larsson (University of Gothenburg)Jens Nielsen (Chalmers University of Technology)Johan Schnürer (Swedish University of Agricultural Sciences)Bernt-Eric Uhlin (Umeå University)Neus Visa (Stockholm University)Henrik Grönberg (Karolinska Institutet)Stefan Ståhl (KTH Royal Institute of Technology)Bengt Westermark (Uppsala University)
6 SciLifeLab Scientific Advisory Board Bertil Andersson, Chair (Nanyang Technological University, Singapore)Sören Brunak (Technical University of Denmark, Denmark)Jan Ellenberg (EMBL Heidelberg, Germany)Yoshihide Hayashizaki (RIKEN Omics Science Center, Japan)Sirpa Jalkanen (University of Turku, Finland)Janet Jansson (Pacific Northwest National Laboratory, Richland, WA, USA)Jonathan Knowles (University of Basel, FIMM University of Helsinki, Switzerland)Svante Pääbo (Max Planck Institute for Evolutionary Anthropology, Germany)Aviv Regev (Broad Institute, MIT, USA)Janet Thornton (EMBL-EBI, UK)
22 Examples of high impact papers 2014 Skoglund P, Malmstrom H, Omrak A, et al Genomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers. Science 344:Wallberg A, Han F, Wellhagen G, et al A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera. Nat Genet 2014;46:Gad H, Koolmeister T, Jemth AS, et al MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508:
23 Examples of high impact papers 2014 Huber KVM, Salah E, Radic B, et al Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 508:Hammar P, Wallden M, Fange D, et al Direct measurement of transcription factor dissociation excludes a simple operator occupancy model for gene regulation. Nature Genet 46:405-Caspeta L, Chen Y, Ghiaci P, et al Biofuels. Altered sterol composition renders yeast thermotolerant. Science 346:75-78 Branca RMM, Orre LM, Johansson HJ, et al HiRIEF LC-MSMS enables deep proteome coverage and unbiased proteogenomics. Nat Methods 11:59-62.
24 Examples of high impact papers 2014 Carneiro M, Rubin CJ, Di Palma F, et al Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. Science 2014;345: -Brawand D, Wagner CE, Li YI, et al The genomic substrate for adaptive radiation in African cichlid fish. Nature 513:375-Dumanski J, Rasi, Lönn M, C, et al Smoking is associated with mosaic loss of chromosome Y. Science Vol. 347 no pp
25 SciLifeLab FellowsMagda Bienko from Massachusetts Institute of TechnologyJens Carlsson from Stockholm UniversitySimon Elsässer from University of CambridgeSebastian Deindl from Harvard UniversityMarc Friedländer from Centre for Genomic Regulation (CRG)Paul Hudson from U.C Berkeley and KTH Royal Institute of TechnologyTanja Slotte from Uppsala UniversityIlaria Testa from Max Planck Institute for Biophysical Chemistry
26 Strategic recruitments Manfred Grabherr from Broad Institute of Harvard and MITCarolina Wählby from Broad Institute of Harvard and MITThomas Helleday from the University of Oxford/Stockholm UniversityLukas Käll from Stockholm UniversitySven Nelander from the University of GothenburgCarsten Daub from RIKENThijs Ettema from Uppsala UniversityErik Ingelsson from Karolinska InstitutetMats Nilsson from Uppsala UniversityPer Arvidsson from AstraZenecaPetter Brodin from Stanford UniversitySimone Immler from Uppsala UniversitySophie Sanchez from Uppsala UniversityCecilia Williams from University of HoustonIn order to strengthen the research environment, SciLifeLab has made several strategic recruitments. Both through ongoing negotiations and through a specific recruitment program launched in The purpose has been to recruit excellent research leaders with good networking abilities and whose research areas strengthen and complement those already represented at SciLifeLab. The recruitments have been made both nationally and internationally to attract the greatest talents. The researchers are financed, mostly by funding of Strategic Research Areas (SFO in Swedish) from the host universities.Manfred GrabherrRecruited from Broad Institute of Harvard and MIT, USA, by Uppsala University in 2011.Carolina WählbyThomas HelledayRecruited from the University of Oxford/Stockholm University to Karolinska InstitutetLukas KällRecruited from Stockholm University, Sweden, by KTH Roylal Institute of Technology in 2011Sven NelanderRecruited from the University of Gothenburg, Sweden, by Uppsala University in 2012.Carsten DaubRecruited from RIKEN, Japan, to Karolinska Institutet in 2012Thijs EttemaRecruited from Uppsala University, Sweden, by Uppsala University in 2013.Erik IngelssonRecruited from Karolinska Institutet, Sweden, by Uppsala University in 2013.Mats NilssonRecruited from Uppsala University, Sweden, by Stockholm University in 2012Per ArvidssonRecruited from AstraZeneca, Sweden, by Karolinska Institutet 2013Petter BrodinRecruited from Stanford University, USA, by Karolinska Institutet 2013Simone ImmlerRecruited from Uppsala University, Sweden, by Uppsala University in 2014.Sophie SanchezCecilia WilliamsRecruited from University of Houston, USA, to KTH Royal Institute of Technology
27 SciLifeLab courses 2014Total number of courses, seminars and workshops (number of events focusing on bioinformatics grouped separately) that SciLifeLab has organized or highly contributed to during 2014.
28 SciLifeLab courses 2014Participants in bioinformatics courses organized by SciLifeLab during University affiliation
29 SciLifeLab courses 2014Level of education - courses, seminars and workshops that SciLifeLab has organized or highly contributed to.
30 AIMday & healthcare Year Activity Description and Results 2011 AIMday Cancer28 workshops with 80 researchers and 21 company representatives2012AIMday Diabetes16 workshops with 70 researchers and 16 company representatives. Resulted in 3 new research collaborations26 workshops with 70 researchers and 28 company representatives. One major spin off was the discussion group on real-time register data (see below). Plus a number of other smaller projects2013AIMday Diagnostics & Biomarkers23 workshops with 60 researchers and 24 company representatives. At least two collaborations started.AIMday CNS Disorders25 workshops with 59 researchers and 31 company representatives.2014Combined program with workshops on specific indications as well as companies’ questions.40 academic researchers and 12 company representatives. One collaboration has started.AIMday BioimagingIn Dec 2014
32 Science & SciLifeLab Prize for young scientists global prize, established in 2013 by the scientific journal Science and SciLifeLabawarded annually to four young scientists for outstanding life science research for which he/she was awarded a doctoral degree in the previous
33 Keystone Symposia on Molecular and Cellular Biology nonprofit organization headquartered in USA50-60 peer-reviewed conferences in life science world wide every yearSciLifeLab supports the organization of Keystone Symposia in Stockholm
34 SciLifeLab – in the media Science 328,805 (14 May 2010)Nature 484, 171 (12 April, 2012)Science 336, 136 (13 April, 2012)SciLifeLab has made the editorial pages of Nature or Science four times since The first article, reporting on the ambitions to ensure that scientists in Sweden have access to all the necessary technology and research resources within the country, appeared in Science in May 2010.In April 2012, both Science and Nature reported on the Swedish Government’s decision to create a true national resource for life science in Sweden. These articles also noted the impressive growth and planned evolution of SciLifeLab.During 2013 SciLifeLab scientists have been interviewed by various media, ranging from the New York Times to National Geographic, from public service to high impact scientific journals.From SciLifeLab’s point of view it was rewarding to read the article “Swedish success story”, published in Nature in October This text answered a question from the earlier Science text, “Is the sum bigger than the components?” with a firm yes. The Nature article focused on the internationally surprising trend that Sweden, in contrast to many other countries, makes great investments in life science infrastructure, and on the ambitious research recruitment plans. The article highlighted the excellent career opportunities and the multidisciplinary strength of the SciLifeLab environment, and also pronounced the potential in the joint venture for excellent collaborative Swedish science.Sources:Science 328, 805, May 14, 2010Nature 484, 171, April 12, 2012Science 336, 136, April 13, 2012Nature 502, 711–712, October 31, 2013Nature 502,(31 October, 2013)