2. Vision
To be an internationally leading center that develops, uses and provides access to advanced technologies for molecular biosciences with focus on health and environment.

3. Organization

4. Board
Professor Göran Sandberg, Government appointed Chair, Executive Director, Knut and Alice Wallenberg Foundation
Margareta Olsson Birgersson, Government appointed Industry representative, Medical Director, Roche Sweden
Professor Sophia Hober, Dean of Faculty, KTH Royal Institute of Technology
Stellan Sandler, Pro Vice-Chancellor, Uppsala University
Professor Hans Adolfsson, Pro Vice-Chancellor, Stockholm University
Professor Hans-Gustaf Ljunggren, Dean of Research, Karolinska Institutet
Professor Maria Anvret, Senior Advisor, University of Gothenburg
Professor Gunilla Westergren-Thorsson, Dean of Faculty of Medicine, Lund University
Professor Karl-Eric Magnusson, Linköping University

5. National Reference Committee
Karl-Eric Magnusson (Linköping University)
Anders Malmström (Lund University)
Göran Larsson (University of Gothenburg)
Jens Nielsen (Chalmers University of Technology)
Johan Schnürer (Swedish University of Agricultural Sciences)
Bernt-Eric Uhlin (Umeå University)
Neus Visa (Stockholm University)
Henrik Grönberg (Karolinska Institutet)
Stefan Ståhl (KTH Royal Institute of Technology)
Bengt Westermark (Uppsala University)

6. SciLifeLab Scientific Advisory Board
Bertil Andersson, Chair (Nanyang Technological University, Singapore)
Sören Brunak (Technical University of Denmark, Denmark)
Jan Ellenberg (EMBL Heidelberg, Germany)
Yoshihide Hayashizaki (RIKEN Omics Science Center, Japan)
Sirpa Jalkanen (University of Turku, Finland)
Janet Jansson (Pacific Northwest National Laboratory, Richland, WA, USA)
Jonathan Knowles (University of Basel, FIMM University of Helsinki, Switzerland)
Svante Pääbo (Max Planck Institute for Evolutionary Anthropology, Germany)
Aviv Regev (Broad Institute, MIT, USA)
Janet Thornton (EMBL-EBI, UK)

7. Scientific directors Executive management Strategic management
Mathias Uhlén
Kerstin Lindblad-Toh
Executive management
Karin Dahlman-Wright
Gunnar von Heijne
Karin Forsberg
Nilsson
Stefan Bertilsson
Strategic management
Joakim Lundeberg
Helene Andersson Svahn
Mats Nilsson
Ulf Landergen

8. Faculty

9. Site management Stockholm

10. Site management Uppsala

11. Funding

12. Platforms and facilities

13. Process for selection

14. Budget

15. SciLifeLab projects 2014

16. SciLifeLab projects 2014

17. SciLifeLab projects 2014 National facilities
Regional facilities of national interest

18. SciLifeLab projects 2014
Distribution of projects by user group

19. SciLifeLab projects 2014
Distribution of projects from organizations outside Swedish academia

20. SciLifeLab projects 2014
Distribution of projects within field of science

21. SciLifeLab publications 2010-2014
514
458
321
221 94

22. Examples of high impact papers 2014
Skoglund P, Malmstrom H, Omrak A, et al Genomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers. Science 344:
Wallberg A, Han F, Wellhagen G, et al A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera. Nat Genet 2014;46:
Gad H, Koolmeister T, Jemth AS, et al MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508:

23. Examples of high impact papers 2014
Huber KVM, Salah E, Radic B, et al Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 508:
Hammar P, Wallden M, Fange D, et al Direct measurement of transcription factor dissociation excludes a simple operator occupancy model for gene regulation. Nature Genet 46:405-
Caspeta L, Chen Y, Ghiaci P, et al Biofuels. Altered sterol composition renders yeast thermotolerant. Science 346:75-78   
Branca RMM, Orre LM, Johansson HJ, et al HiRIEF LC-MSMS enables deep proteome coverage and unbiased proteogenomics. Nat Methods 11:59-62.

24. Examples of high impact papers 2014
Carneiro M, Rubin CJ, Di Palma F, et al Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. Science 2014;345:              
                       
-Brawand D, Wagner CE, Li YI, et al The genomic substrate for adaptive radiation in African cichlid fish. Nature 513:375-
Dumanski J, Rasi, Lönn M, C, et al Smoking is associated with mosaic loss of chromosome Y. Science Vol. 347 no pp  

25. SciLifeLab Fellows
Magda Bienko from Massachusetts Institute of Technology
Jens Carlsson from Stockholm University
Simon Elsässer from University of Cambridge
Sebastian Deindl from Harvard University
Marc Friedländer from Centre for Genomic Regulation (CRG)
Paul Hudson from U.C Berkeley and KTH Royal Institute of Technology
Tanja Slotte from Uppsala University
Ilaria Testa from Max Planck Institute for Biophysical Chemistry

26. Strategic recruitments
Manfred Grabherr from Broad Institute of Harvard and MIT
Carolina Wählby from Broad Institute of Harvard and MIT
Thomas Helleday from the University of Oxford/Stockholm University
Lukas Käll from Stockholm University
Sven Nelander from the University of Gothenburg
Carsten Daub from RIKEN
Thijs Ettema from Uppsala University
Erik Ingelsson from Karolinska Institutet
Mats Nilsson from Uppsala University
Per Arvidsson from AstraZeneca
Petter Brodin from Stanford University
Simone Immler from Uppsala University
Sophie Sanchez from Uppsala University
Cecilia Williams from University of Houston
In order to strengthen the research environment, SciLifeLab has made several strategic recruitments. Both through ongoing negotiations and through a specific recruitment program launched in The purpose has been to recruit excellent research leaders with good networking abilities and whose research areas strengthen and complement those already represented at SciLifeLab. The recruitments have been made both nationally and internationally to attract the greatest talents. The researchers are financed, mostly by funding of Strategic Research Areas (SFO in Swedish) from the host universities.
Manfred Grabherr
Recruited from Broad Institute of Harvard and MIT, USA, by Uppsala University in 2011.
Carolina Wählby
Thomas Helleday
Recruited from the University of Oxford/Stockholm University to Karolinska Institutet
Lukas Käll
Recruited from Stockholm University, Sweden, by KTH Roylal Institute of Technology in 2011
Sven Nelander
Recruited from the University of Gothenburg, Sweden, by Uppsala University in 2012.
Carsten Daub
Recruited from RIKEN, Japan, to Karolinska Institutet in 2012
Thijs Ettema
Recruited from Uppsala University, Sweden, by Uppsala University in 2013.
Erik Ingelsson
Recruited from Karolinska Institutet, Sweden, by Uppsala University in 2013.
Mats Nilsson
Recruited from Uppsala University, Sweden, by Stockholm University in 2012
Per Arvidsson
Recruited from AstraZeneca, Sweden, by Karolinska Institutet 2013
Petter Brodin
Recruited from Stanford University, USA, by Karolinska Institutet 2013
Simone Immler
Recruited from Uppsala University, Sweden, by Uppsala University in 2014.
Sophie Sanchez
Cecilia Williams
Recruited from University of Houston, USA, to KTH Royal Institute of Technology

27. SciLifeLab courses 2014
Total number of courses, seminars and workshops (number of events focusing on bioinformatics grouped separately) that SciLifeLab has organized or highly contributed to during 2014.

28. SciLifeLab courses 2014
Participants in bioinformatics courses organized by SciLifeLab during University affiliation

29. SciLifeLab courses 2014
Level of education - courses, seminars and workshops that SciLifeLab has organized or highly contributed to.

30. AIMday & healthcare Year Activity Description and Results 2011
AIMday Cancer
28 workshops with 80 researchers and 21 company representatives
2012
AIMday Diabetes
16 workshops with 70 researchers and 16 company representatives. Resulted in 3 new research collaborations
26 workshops with 70 researchers and 28 company representatives. One major spin off was the discussion group on real-time register data (see below). Plus a number of other smaller projects
2013
AIMday Diagnostics & Biomarkers
23 workshops with 60 researchers and 24 company representatives. At least two collaborations started.
AIMday CNS Disorders
25 workshops with 59 researchers and 31 company representatives.
2014
Combined program with workshops on specific indications as well as companies’ questions.40 academic researchers and 12 company representatives. One collaboration has started.
AIMday Bioimaging
In Dec 2014

31. Outreach activities
SciLifeLab Day
Workshops
Roadshows

32. Science & SciLifeLab Prize for young scientists
global prize, established in 2013 by the scientific journal Science and SciLifeLab
awarded annually to four young scientists for outstanding life science research for which he/she was awarded a doctoral degree in the previous

33. Keystone Symposia on Molecular and Cellular Biology
nonprofit organization headquartered in USA
50-60 peer-reviewed conferences in life science world wide every year
SciLifeLab supports the organization of Keystone Symposia in Stockholm

34. SciLifeLab – in the media
Science 328,805 (14 May 2010)
Nature 484, 171 (12 April, 2012)
Science 336, 136 (13 April, 2012)
SciLifeLab has made the editorial pages of Nature or Science four times since The first article, reporting on the ambitions to ensure that scientists in Sweden have access to all the necessary technology and research resources within the country, appeared in Science in May 2010.
In April 2012, both Science and Nature reported on the Swedish Government’s decision to create a true national resource for life science in Sweden. These articles also noted the impressive growth and planned evolution of SciLifeLab.
During 2013 SciLifeLab scientists have been interviewed by various media, ranging from the New York Times to National Geographic, from public service to high impact scientific journals.
From SciLifeLab’s point of view it was rewarding to read the article “Swedish success story”, published in Nature in October This text answered a question from the earlier Science text, “Is the sum bigger than the components?” with a firm yes. The Nature article focused on the internationally surprising trend that Sweden, in contrast to many other countries, makes great investments in life science infrastructure, and on the ambitious research recruitment plans. The article highlighted the excellent career opportunities and the multidisciplinary strength of the SciLifeLab environment, and also pronounced the potential in the joint venture for excellent collaborative Swedish science.
Sources:
Science 328, 805, May 14, 2010
Nature 484, 171, April 12, 2012
Science 336, 136, April 13, 2012
Nature 502, 711–712, October 31, 2013
Nature 502,
(31 October, 2013)

35. Issues & opportunities

36. Future remarks