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Vision To be an internationally leading center that develops, uses and provides access to advanced technologies for molecular biosciences with focus on.

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Presentation on theme: "Vision To be an internationally leading center that develops, uses and provides access to advanced technologies for molecular biosciences with focus on."— Presentation transcript:

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2 Vision To be an internationally leading center that develops, uses and provides access to advanced technologies for molecular biosciences with focus on health and environment.

3 Organization

4 Board Professor Göran Sandberg, Government appointed Chair, Executive Director, Knut and Alice Wallenberg Foundation Margareta Olsson Birgersson, Government appointed Industry representative, Medical Director, Roche Sweden Professor Sophia Hober, Dean of Faculty, KTH Royal Institute of Technology Stellan Sandler, Pro Vice-Chancellor, Uppsala University Professor Hans Adolfsson, Pro Vice-Chancellor, Stockholm University Professor Hans-Gustaf Ljunggren, Dean of Research, Karolinska Institutet Professor Maria Anvret, Senior Advisor, University of Gothenburg Professor Gunilla Westergren-Thorsson, Dean of Faculty of Medicine, Lund University Professor Karl-Eric Magnusson, Linköping University

5 National Reference Committee Karl-Eric Magnusson (Linköping University) Anders Malmström (Lund University) Göran Larsson (University of Gothenburg) Jens Nielsen (Chalmers University of Technology) Johan Schnürer (Swedish University of Agricultural Sciences) Bernt-Eric Uhlin (Umeå University) Neus Visa (Stockholm University) Henrik Grönberg (Karolinska Institutet) Stefan Ståhl (KTH Royal Institute of Technology) Bengt Westermark (Uppsala University)

6 SciLifeLab Scientific Advisory Board Bertil Andersson, Chair (Nanyang Technological University, Singapore) Sören Brunak (Technical University of Denmark, Denmark) Jan Ellenberg (EMBL Heidelberg, Germany) Yoshihide Hayashizaki (RIKEN Omics Science Center, Japan) Sirpa Jalkanen (University of Turku, Finland) Janet Jansson (Pacific Northwest National Laboratory, Richland, WA, USA) Jonathan Knowles (University of Basel, FIMM University of Helsinki, Switzerland) Svante Pääbo (Max Planck Institute for Evolutionary Anthropology, Germany) Aviv Regev (Broad Institute, MIT, USA) Janet Thornton (EMBL-EBI, UK)

7 Scientific directors Executive management Mathias UhlénKerstin Lindblad-Toh Karin Dahlman- Wright Strategic management Gunnar von HeijneKarin Forsberg Nilsson Stefan Bertilsson Joakim Lundeberg Helene Andersson Svahn Mats Nilsson Ulf Landegen

8 Site management Stockholm

9 Site management Uppsala

10 Funding

11 Platforms and facilities

12 SciLifeLab projects 2014

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14 Regional facilities of national interest National facilities

15 SciLifeLab projects 2014 Distribution of projects by user group

16 SciLifeLab projects 2014 Distribution of projects from organizations outside Swedish academia

17 SciLifeLab projects 2014 Distribution of projects within field of science

18 SciLifeLab publications

19 Examples of high impact papers 2014 Skoglund P, Malmstrom H, Omrak A, et al Genomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers. Science 344: Wallberg A, Han F, Wellhagen G, et al A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera. Nat Genet 2014;46: Gad H, Koolmeister T, Jemth AS, et al MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508:

20 Examples of high impact papers 2014 Huber KVM, Salah E, Radic B, et al Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 508: Hammar P, Wallden M, Fange D, et al Direct measurement of transcription factor dissociation excludes a simple operator occupancy model for gene regulation. Nature Genet 46:405- Caspeta L, Chen Y, Ghiaci P, et al Biofuels. Altered sterol composition renders yeast thermotolerant. Science 346:75-78 Branca RMM, Orre LM, Johansson HJ, et al HiRIEF LC-MSMS enables deep proteome coverage and unbiased proteogenomics. Nat Methods 11:59-62.

21 Examples of high impact papers 2014 Carneiro M, Rubin CJ, Di Palma F, et al Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. Science 2014;345: Brawand D, Wagner CE, Li YI, et al The genomic substrate for adaptive radiation in African cichlid fish. Nature 513:375- Dumanski J, Rasi, Lönn M, C, et al Smoking is associated with mosaic loss of chromosome Y. Science Vol. 347 no pp

22 SciLifeLab Fellows Magda Bienko from Massachusetts Institute of Technology Jens Carlsson from Stockholm University Simon Elsässer from University of Cambridge Sebastian Deindl from Harvard University Marc Friedländer from Centre for Genomic Regulation (CRG) Paul Hudson from U.C Berkeley and KTH Royal Institute of Technology Tanja Slotte from Uppsala University Ilaria Testa from Max Planck Institute for Biophysical Chemistry

23 Strategic recruitments Manfred Grabherr from Broad Institute of Harvard and MIT Carolina Wählby from Broad Institute of Harvard and MIT Thomas Helleday from the University of Oxford/Stockholm University Lukas Käll from Stockholm University Sven Nelander from the University of Gothenburg Carsten Daub from RIKEN Thijs Ettema from Uppsala University Erik Ingelsson from Karolinska Institutet Mats Nilsson from Uppsala University Per Arvidsson from AstraZeneca Petter Brodin from Stanford University Simone Immler from Uppsala University Sophie Sanchez from Uppsala University Cecilia Williams from University of Houston

24 SciLifeLab courses 2014 Total number of courses, seminars and workshops (number of events focusing on bioinformatics grouped separately) that SciLifeLab has organized or highly contributed to during 2014.

25 SciLifeLab courses 2014 Participants in bioinformatics courses organized by SciLifeLab during University affiliation

26 SciLifeLab courses 2014 Level of education - courses, seminars and workshops that SciLifeLab has organized or highly contributed to.

27 AIMday & healthcare YearActivityDescription and Results 2011AIMday Cancer28 workshops with 80 researchers and 21 company representatives 2012AIMday Diabetes16 workshops with 70 researchers and 16 company representatives. Resulted in 3 new research collaborations 2012AIMday Cancer26 workshops with 70 researchers and 28 company representatives. One major spin off was the discussion group on real-time register data (see below). Plus a number of other smaller projects 2013AIMday Diagnostics & Biomarkers 23 workshops with 60 researchers and 24 company representatives. At least two collaborations started. 2013AIMday CNS Disorders25 workshops with 59 researchers and 31 company representatives. 2014AIMday CancerCombined program with workshops on specific indications as well as companies’ questions.40 academic researchers and 12 company representatives. One collaboration has started. 2014AIMday BioimagingIn Dec 2014

28 Outreach activities SciLifeLab Day Workshops Roadshows

29 Science & SciLifeLab Prize for young scientists global prize, established in 2013 by the scientific journal Science and SciLifeLab awarded annually to four young scientists for outstanding life science research for which he/she was awarded a doctoral degree in the previous

30 Keystone Symposia on Molecular and Cellular Biology nonprofit organization headquartered in USA peer-reviewed conferences in life science world wide every year SciLifeLab supports the organization of Keystone Symposia in Stockholm

31 SciLifeLab – in the media Nature 484, 171 (12 April, 2012) Science 328,805 (14 May 2010) Science 336, 136 (13 April, 2012) Nature 502, (31 October, 2013)


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