1. BIG GRANTS, BIG DEAL: Tools and Ideas for Large Grant Submissions Daniel Rademacher Robert H. Lurie Comprehensive Cancer Center Deborah Cundiff McCormick School of Engineering and Applied Science, Office of Research Administration Alden Chang Office of Research Development

2. What is a Big Research Grant?  National Institutes of Health (NIH): P & U Mechanisms (e.g., P50 or U54)  National Science Foundation (NSF): Centers (e.g., Science and Technology Centers)  U.S. Department of Energy (DOE): Centers or Hubs (e.g., Energy Frontier Research Centers)

3. Step 1: Solicitation is released or PI approaches you regarding a large project Review the solicitation for requirements.  Review agency policy for unsolicited applications. NIH applications over $500K require Data Sharing Plans NIH grants over $500K direct costs in any year require prior approval. NIH applications (except those assigned to NIGMS, NICHD, NEI, NIDCR, or NINR) requesting $500,000 or more in direct costs for any year must include a cover letter identifying the NIH staff member within one of the NIH ICs who has agreed to accept assignment of the application.

4. Big Grants Sometimes Have Unique Requirements Required travel (to agency meetings) Holding annual symposia Mandatory/suggested cost sharing (talk with the Office of Research Development [ORD]) Quarterly conference calls Budget set asides (e.g., Pilot Project Program, Career Development) Letters of institutional support (VPR, Dean, OSR) Pre-proposal required/mandatory letter of intent

5. Step 2: Meet with your Investigators Discuss the co-investigators and affiliations Discuss basic budgetary requirements, including investigator effort Discuss engaging other departmental/ school/ institutional research administration resources, e.g., ORD Is the PI/PD discussing the submission with Program Officer/Official? Review regulatory items (animals, humans, stem cells) For multiple projects and cores under a single award discuss budgetary and F & A allotment per project/core Determine administrative costs (OMB A21 allows for administrative costs when appropriate) Establish a time line and responsibilities

6. Example of Sponsor Driven Timeline

7. Step 3: Get Organized Create a contact list Investigators Name and Email Administrative Contact and Email Create folders for each proposal component you’ll need to complete Create a budget spreadsheet to support multiple projects Continue to communicate with PI/PD either in person or by phone and e-mail

8. Example of Organizing Tool

9. Ideas for Electronic Organization

10. Step 4: Contact Individuals Involved Prepare required documents (e.g., biographical sketch, current and pending support, resources, letters of intent, and letters of support). Budget and justification if subcontract Pre-fill the above documents and send to the investigator and their administrative contact Emails should be concise and should include deadlines Contact OSR with your deadlines/expectations

11. Example of an Email to Investigator

12. Example of an Email to a SubK Investigator

13. Step 5: Prepare Overall Paperwork Populate your budget Collect overall information Follow-up on your email requests Prepare institutional paperwork (e.g., OSR-1, OSR-100)  Indicate redistribution of accounts and F&A, if applicable  Follow up on any missing signatures Work with Tech Transfer (INVO) on Data Sharing Plan Do you require Institutional Support (monetary or other)?

14. Step 6: Check your Preparedness If paper-does your department have enough paper, toner, binder clips or rubber bands to submit? Will you be required to submit additional copies on CDs?  Do you have enough CDs?  Will you require cover and disc art? How will you paginate? Do you have the right FedEx Supplies? Have plenty of caffeine on hand

15.  Step 7: Submit  Step 8: Supplemental Information  Step 9: Revisions/NIH Just in Time (JIT)  Step 10: Award  Step 11: Progress Report (Get out your Contact Sheet)

16. Thank You! Questions/Comments? Daniel Rademacher RHLCCC d-rademacher2@northwestern.edu Deborah Cundiff McC Research Administration deb@northwestern.edu Alden Chang ORD alden-chang@northwestern.edu