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Introduction to Research at WRNMMC

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1 Introduction to Research at WRNMMC
2011 Walter Reed National Military Medical Center Directorate for Professional Education Department of Research Programs Introduction to Research at WRNMMC Marina Borovok, PhD Head of Research Education, Department of Research Programs, WRNMMC September 2011 Welcome to the first offering of our new introduction to research course! We hope this will give you a feeling for how to navigate the research process in general, and specifically here at NNMC. I am Dr Jeff Lenert, the head of Clinical Investigations here at NNMC and we want you to be able to put some faces with the names of people here who can help you generate and complete your research projects. Thanks for your interest and thanks for coming. I hope it is worthwhile. Toward that end the content of the course was developed in response to surveys undertaken over the past year asking what people with an interest in research wanted to learn more about. We can further tailor and improve the content if you would please give feedback on the course directly as well as by filling out your evaluation forms. Research Course

2 Disclosure Statement :
This CE/CME activity does not have commercial support, and has no conflicts of interest. 2011 2011 Research Course Research Course 2 Research Course

3 2011 Learning Objectives Describe clinical research and the research process steps Discus research at WRNMMC and it’s unique opportunities. 3. Know about research support available at WRNMMC. Recognize IT tools that support research collaboration and communication from anywhere at any time. In my presentation I’d like to accomplish the following… 2011 Research Course Research Course 3 Research Course

4 LO 1: Describe clinical research and the research process steps
Before you start your research at WRNMMC, you need to do the following THREE steps: Step 1: Obtaining a DKO/AKO account Step 2: Registering with IRBNet, e-portal for publications and protocol submission. Step 3: Completion of CITI training 2011 Research Course

5 Research Cue Card 2011 Research Course

6 Step 1: Obtaining a DKO/AKO account
AKO/DKO platform for research purposes What is AKO? Army Knowledge Online (AKO) is the world's largest and secure electronic platform. AKO is currently serving over 2.26 million users. What is DKO? Defense Knowledge Online (DKO) is an information sharing network required by the Department of Defense to support secure access to information (portal). DKO is using AKO as a platform. 2011 Research Course

7 MANY Benefits of DKO 1. Universal Email in the .mil environment.
2. Virtual workspace (telework) any time especially in times of national disaster (Sept 11, Pandemic, etc) or exercises (example: DCO) 3. Virus and Spam scanning for over 3 Billion messages per year. 4. Provides access to over 2K free training courses via JKO, etc. 5. Use AKO/DKO credentials to access MyPay, Tricare Online and over 1,200 other DOD applications that use AKO/DKO SSO services. 6. If you have Internet access, you can access AKO/DKO securely from anywhere at any time 7. Centralized Helpdesk (open 24/7) supporting 2.26M users and over 1,200 DoD applications. 8. Use AKO/DKO Portal as a Virtual Thumb Drive ensuring files and folders needed are available regardless of location. 9. Social capabilities such as milSUITE allow you to find new people working on similar projects or with similar interests. 10. Communicate with anyone in DoD via IM, , video messaging. 11. Over 50K deployed US Armed Forces members use AKO/DKO while deployed to many places worldwide. 2011 Research Course

8 AKO/DKO platform for research purposes The Defense Medical Research Network (DMRN)
For better management of research processes, The Defense Medical Research Network (DMRN) was created. It is a DoD-wide web-based networking solution for all your research management, compliance and oversight needs. Located on AKO/DKO platform at: https://www.us.army.mil/suite/page/596540 IRBNet IRBNet is the industry leading software, a robust set of electronic tools supporting the management, submission, review and oversight of our research protocols. IRBNet entry is available through DMRN page that located on AKO/DKO site. 2011 Research Course

9 Step 1: Obtaining a DKO/AKO account
Go to the Defense Medical Research Network (DMRN)page on DKO/AKO website at https://www.us.army.mil/suite/page/596540 Cue Card Reference: 2011 Research Course

10 Step 1: Obtaining a DKO/AKO account (cont.)
Login using your AKO/DKO username and password 2011 Research Course

11 Step 1: Obtaining a DKO/AKO account (cont.)
You are at the DMRN site at https://www.us.army.mil/suite/page/596540 Click on the IRBNet Entry button 2011 Research Course

12 Step 1: Obtaining a DKO/AKO account (cont.)
Instructions are at the RCRS website https://nnmcintra/SiteDirectory/RCRS/IRBNet/Forms/AllItems.aspx. Questions? Contact Ms. Dale Gregory 2011 Research Course

13 Instructions are at the RCRS website
Step 2: Registering with IRBNet, e-portal for publications and protocol submission. Cue Card Reference: Instructions are at the RCRS website https://nnmcintra/SiteDirectory/RCRS/IRBNet/Forms/AllItems.aspx. 2011 Research Course

14 Step 2: Registering with IRBNet, e-portal for publications and protocol submission (cont.)
Questions? Please contact Mr. Luis Calvo at 2011 Research Course

15 Step 3: Completion of CITI training
Cue Card Reference: Principal Investigators, Associate Investigators, Research Staff, as well as anyone coming into contact with Human Subjects or involved with the consent process or study design are required to complete this course. 2011 Research Course

16 Step 3: Completion of CITI training
The course is available at https://www.citiprogram.org First Time Users need to register at https://www.citiprogram.org/enroll/courseregistration1.asp?language=english. Questions? Contact Dr. Marina Borovok 2011 Research Course

17 Now you are done with the registrations and training. What is next?
2011 Research Course

18 Next steps: 4-5 The entire research writing process can be divided into easily manageable and clear steps: STEP 4: Develop a Research Question Select a topic Discuss Research Ideas Find Sources to support your ideas STEP 5: Submit your proposal via Proposal Approval Funding (if needed) Research Course

19 Step 4: Develop Research Question Good research question: could the "FINER" criteria be applied to it? F- Feasible.  Is the question answerable?  Do you have access to all the materials you will need to do the study?  Do you have access to enough subjects?  Will you have enough time and money?  Do you have the expertise to do this study or can you collaborate with someone who does? I- Interesting.  The question has to be interesting to the investigator, but should also be interesting to others. N- Novel.  Has this study been done before?  Does it add to the current body of medical knowledge? E- Ethical.  Risk/benefit ratio? Can the study be done with a minimal risk?  Will an IRB approve the study? R- Relevant.  Will it further medical science?  Will the results change clinical practice, health policy or point towards further avenues of research? If your question fails on any one of these 5 criteria, it is probably not worth putting much effort into. 2011 Research Preparation Course

20 STEP 4: Good research question (cont.)
Readings: Designing clinical research: an epidemiologic approach, 3rd ed., by Stephen B. Hulley, et.al. Lippincott Williams & Wilkins, 2007 ISBN: ; Research begins with the question. 2011 Research Course

21 Step 4: Research topic selection
Cue Card Reference: In order to do that you need to consult with your Department Chair/Supervisor/Mentor. Need help to choose your Mentor? Please contact Dr. Marina Borovok at 2011 Research Course

22 Step 4: Research topic selection (cont.) In case if you need HELP
Choose your mentor, and ask him/her to help. INTERNET Web resource : 2011 Research Course

23 Protocol Outreach Program to discuss research ideas and roadmap:
Step 4: Research topic selection (cont.) New: Protocol Outreach Program Protocol Outreach Program to discuss research ideas and roadmap: Clinician, statistician, regulatory reviewer, laboratory scientist 45 min appointments for research ideas and roadmap. More information will be provided by Dr. Klote (Module 6), and Dr. Bernstein (Module 7). To schedule an appointment please contact Ms. Dale Gregory at , or 2011 Research Course

24 Step 5: Protocol submission via
Cue Card Reference: Submission instructions are available on the IRBNet portal, under Forms and Templates. Questions? Contact DRP 2011 Research Course

25 Next steps are: Proposal Approval (SRP,IRB approval), Funding (if needed).
These steps will be successful if you worked on the Research Protocol with help of the WRNMMC specialists (Step 4) 2011 Research Course

26 Research Funding Information on Research Funding is provided By Dr. Kaminsky (Day 2, Module 9). 2011 Research Course

27 IMPORTANT TO REMEMBER !!! Cue Card Reference:
You may not begin your research until you have received an IRB Approval and Approval Letter from the Commander, WRNMMC. 2011 Research Course

28 The National Capital Region Military Medical Centers POCs:
Walter Reed National Military Medical Center DRP (WRNMMC) , Malcolm Grow Medical Center (MGMC), IRB Office Cheryl James The Uniformed Services University (USU), Research Office Maggie Pickerel 2011 Research Course

29 Questions? 2011 Research Course

30 LO 2: Discus research at WRNMMC and it’s unique opportunities
WRNMMC’s goal remains to promote excellence in health care and militarily relevant research and human subject protection. Department of Research Programs (DRP) Human subject protection, research compliance and integrity; research administration, support, funding, publication and education. https://nnmcintra/SiteDirectory/RCRS/default.aspx 2011 Research Course

31 Current research efforts at WRNMMC are ongoing:
Research at WRNMMC Current research efforts at WRNMMC are ongoing: head injury/TBI, stroke, colon, breast cancer, leukemia and lymphoma, investigational chemotherapy, virtual colonoscopy, diabetes management, infectious disease, dental imaging. 2011 Research Course Research Course 31

32 Open Protocols at WRNMMC
List is available on the Intranet at: https://nnmcintra/SiteDirectory/RCRS/Lists/Open%20Protocols/AllItems.aspx?View=%7b40123BB7%2dBE3A%2d4899%2d9423%2dB28C17B522E1%7d Go to the Department of Research programs (DRP)) Intranet site at https://nnmcintra/SiteDirectory/RCRS/default.aspx and click on Open Protocols 2011 Research Course

33 Questions? 2011 Research Course

34 LO 3: Know about research support available at WRNMMC.
WRNMMC Research Resources Research Integrity Resources Department of Research Programs (DRP), Darnall Biomedical Learning Resource Center Research Protocol/Publication Help, Education/Mentoring Resources, Protocol Outreach Program ICEBERG, IT tools. 2011 Research Course

35 Research Integrity Resources
2011 It is a policy of WRNMMC that all personnel will uphold highest principles of ethics promoting research integrity and the responsible conduct of research (RCR). RCR RESOURCES (web links): TEXT On Being A Scientist, National Academy of Sciences Committee on the Conduct of Science, 3rd Ed., Also available on the web at DVD “THE LAB” an interactive educational DVD has been developed by ORI for education regarding research misconduct. Also available on the web at RCRS site at https://nnmcintra/SiteDirectory/RCRS/default.aspx (under the RCRS links), WEB RESOURCES PROVIDED ON THE DRP WEBSITE (INTRANET) at: https://nnmcintra/SiteDirectory/RCRS/default.aspx (under DRPLinks): RESEARCH INTEGRITY THE LAB: Interactive Movie on Research Misconduct AVOID PLAGIARISM: 26 Guidelines at a glance Research Ethics Resources provided by The Navy Medicine Institute On Being a Scientist: A Guide to Responsible Conduct in Research: Third Edition (2009) Research Course

36 Research Integrity Resources (cont.)
ANTI-PLAGIARISM SOFTWARE TURNITIN Web-based, Free access available to the WRNMMC researchers. Ask Ann Holman to help with Turnitin registration: , Example of report : slide # 64 RESEARCH INTEGRITY DISCUSSIONS ETHICS ROUNDTABLE: FRIDAYS (once/month, ) By Darnall Biomedical Learning Resource Center (Formerly Stitt Library) https://nnmcintra/SiteDirectory/Darnall/Lists/Calendar/calendar.aspx 2011 Research Course

37 Department of Research Programs (DRP) Cue Card Reference:
2011 Research Course

38 DRP information DEPARTMENT OF RESEARCH PROGRAMS (DRP)
Bldg. 17, 3rd floor, suite 3C DRP Chief LTC Klote, MD, MC (no voic ) Questions: , or DRP Intranet https://nnmcintra/SiteDirectory/RCRS/default.aspx 2011 Research Course

39 Darnall Biomedical Learning Resource Center (DBLRC)
Bldg. 1, 3 rd floor, room 3458, ph Hours Monday-Thursday   Friday                    Online Access is available via Athens. Athens Registration : https://register.athensams.net/nnmc/ Ask Ann Holman to help with Athens registration , After Hours Access is available Contact Ann Holman at or visit the Circulation Desk to sign up for an access account, and we'll contact you when your card is ready.  Library Access Card 2011 Research Course

40 Darnall Biomedical Learning Resource Center (DBLRC)
Intranet https://nnmcintra/SiteDirectory/Darnall/default.aspx Stitt Internet Questions: 2011 Research Course

41 Research Protocol/Publication Help
*Literature Search: Comprehensive DB specialist: Mr. Fredric Simms, MLS Reference Librarian: Kimberly D. Adams, M.A., M.S., M.L.S. *Statistical Data Analysis: Audrey Chang, PhD , Robin Howard, MA Francois O. Tuamokumo, PhD *These specialists provide hands-on workshops. 2011 Research Course

42 Education/Mentoring Resources
Head of Research Education: Marina Borovok, PhD Cue Card Reference: 2011 Research Course

43 Educational Resources
2011 Educational Resources Research Course: 9 CME/CE, 2 days ( ) Next 2011 Research Course: November 8-9, 2011 Course PP slide show is available at: https://nnmcintra/SiteDirectory/RCRS/default.aspx (under DRP Research School) 2011 Research Course Research Course

44 Educational Resources
Hands-on Research Preparation Course April-December, 2011, once/month, noon-1400. Next Class is on September 27, 2011 (session on IRB registration) Location: Bldg. 57, ROOM 1214-B Next Meeting Dates: 9/27, 10/13, 11/17, 12/15 This course provides participants with the practical skills required for writing a research proposal, completing research project, submitting research results to the WRNMMC Research Competition and a peer- reviewed journal in their specialty field. 2011 Research Course

45 Educational resources (cont.)
PubMed Search Course Developed and presented by the National Library of Medicine 2011 DATES: Tentative dates: 10/20, 12/2 TIME: LOCATION: WRNMMC, Bldg 57, room 1214 B COURSE GOAL To provide guidelines for PubMed search, and teach researchers how to perform searches on their own. REGISTRATION: PLEASE CONTACT Ms. Ann Holman: , or via at 2011 Research Course

46 PubMed LINKS The PubMed links are posted on the Intranet:
RCRS and Darnall Center websites DRP website https://nnmcintra/SiteDirectory/RCRS/default.aspx Darnall Center Website https://nnmcintra/SiteDirectory/Darnall/default.aspx 2011 Research Course

47 Hands-on Educational WORKSHOPS
Workshops are offered all year long at WRNMMC on a per-request basis. Topics: Literature Search by Mr. Fredric Simms Statistical Analysis by Dr. Tuamokumo, Dr. Chang, and Ms. Howard Please contact our specialists to schedule a workshop 2011 Research Course Research Course 47

48 Protocol Outreach Program
To discuss research ideas and roadmap: Clinician, statistician, regulatory reviewer, laboratory scientist 45 min appointments for research ideas and roadmap. More information will be provided by Dr. Klote (Module 6), and Dr. Bernstein (Module 7). To schedule an appointment please contact Ms. Dale Gregory at , or 2011 Research Course

49 WRNMMC-USUHS mentorship initiative
MENTORSHIP RESOURCES WRNMMC-USUHS mentorship initiative USUHS If you are looking for a mentor in the specific areas of research, clinical work, education, professional development, please contact mentorship representatives at USUHS, and they will help you to find a mentor from the USUHS mentorship network: Andrew Waters, Chair of Research Committee Dr. Jennifer Rusiecki or Dr. Barbara Knollman Co-chairs of Faculty Mentoring Committee WRNMMC If you are looking for a mentor in the specific areas of military research, please contact research mentorship representative at WRNMMC: Marina Borovok, PhD Head of Research Education. On the web: 2011 Research Course

50 MENTORSHIP RESOURCES Interdepartmental Collaborative Bethesda Research Group
MISSION Help WRNMMC to become a premier research organization in the Department of Defense. 2011 Research Course

51 Questions? 2011 Research Course

52 Resources IT tools: Turnitin
Turnitin is a Plagiarism Prevention Software. Website: Plagiarism Prevention: Instantly identifies papers containing unoriginal material. Peer Review: Participants can review and respond to their colleagues' work online. 2011 Research Course Research Course 52

53 Turnitin http://turnitin.com/static/index.php
Resources: IT tools Turnitin Example of report 2011 Research Course Research Course 53

54 Resources: IT tools IRBNet www.irbnet.org
IRBNet is the industry leading software, a robust set of electronic tools supporting the management, submission, review and oversight of our research protocols. IRBNet is secure, web-based, and easy to use. 2011 Research Course Research Course 54

55 Collaborative E-applications
LO 4: Recognize IT tools that support research collaboration and communication from anywhere at any time. Collaborative E-applications Defense Connect Online (DCO) - Synchronous Wikis - Asynchronous Google Docs - Asynchronous 2011 Research Course

56 Best collaborative platform AKO/DKO www.us.army.mil
2011 Research Course

57 Virtual meeting room DCO
https://www.dco.dod.mil 2011 Research Course Research Course 57

58 DCO– Defense Connect Online
DCO– Defense Connect Online - provides DoD users worldwide with a second option for enterprise collaboration services. The DCO meeting room capabilities are: the DCO Portal, webconferencing, instant messaging, screen and file sharing, whiteboard, video and audio capabilities, hosting large meetings, and more. 2011 Research Course

59 Virtual meeting room DCO
2011 Live Training Schedule is available at: https://www.dco.dod.mil/public/dsp/liveTraining.cfm To participate in live training: Go to https://connect.dco.dod.mil/dcoliveremotetraining Enter as a guest 2011 Research Course Research Course 59

60 Wikis http://www.wikispaces.com/
A wiki is a website that can be edited by anyone who is granted permission. It is simple and powerful knowledge sharing and collaboration online tool that solves problems of Document management for a Team Project Management in an enterprise. Other advantages of wiki: cheap or free, simple enough for non-technical employees to use. Detailed instructions on how to create a wiki page are available at 2011 Research Course

61 Wikis Wiki Examples: Wikipedia: http://en.wikipedia.org/wiki/Main_Page
WRNMMC ICEBERG: 2011 Research Course

62 Wikis Wiki at WRNMMC ICEBERG (Interdepartmental Collaborative Bethesda Research Group) 2011 Research Course

63 Google Docs https://www.docs.google.com
GoogleDocs is a free web-based collaborative software.  It has applications of word processors, spreadsheet and presentations that are similar to Word, Excel and PowerPoint. Several useful functions are: autosave, revision history and rename of the files. It allows users to create and edit documents online while collaborating in real-time with other users. 2011 Research Course

64 References: Hulley, S. et al.(2007), Designing Clinical Research, 2nd ed. Lippincott Williams & Wilkins On Being a Scientist: A Guide to Responsible Conduct in Research: Third Edition. (2009). Committee on Science, Engineering, and Public Policy, National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. Goodnoe, E. (2005). How To Use Wikis For Business. The InformationWeek Business Technology Network. Retrieved March 11, 2010, from Pfeifer, S. (March 11, 2008). Wikis and Blogs. Presented at Administrative and Instructional Uses of Technology, ED (91) lecture at Johns Hopkins University. Riedel, C. (2008). Turnitin Integrates Plagiarism Tool into New Online Writing Service. Retrieved March 10, 2010, from Auga, N. (2006). Developing wikis to foster web-based learning communities: an iterative approach, International Journal of Web Based Communities (IJWBC), Vol.2, No.3. Retrieved March 12, 2010, from 2011 Research Course

65 Questions? 2011 Research Course

66 2011 Thank You! My Contact Information: Marina Borovok, PhD Head of Research Education Department of Research Programs Directorate for Professional Education Walter Reed National Military Medical Center 8901 Wisconsin Avenue, Bldg. 1, Rm. 4372, Bethesda, MD 20889 Phone: Fax: 2011 Research Course Research Course 66 Research Course


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