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Pharmacology – A Class Act St. Louis, MO March 22, 2014.

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1 Pharmacology – A Class Act St. Louis, MO March 22, 2014

2 Choosing a route of administration Remember—topical drugs CAN have systemic absorption and side effects Most of the time this is NOT a problem A few exceptions to mention:

3 Beta-blocker eye drops for glaucoma—second-line therapy-- Lower intraocular pressure by 20-25% with once or twice daily dosing Betoxolol (Betoptic, Betoptic S), timolol (Betimol, Timoptic, Timoptic XE, Istalol, Timoptic Ocudose), levobunolol (Betagan), carteolol (Ocupress), metipranolol (Optipranolol) Highly lipid-soluble and cross the blood-brain barrier Can cause bradycardia and anhedonia So what can you use instead?

4 The “oprosts”—first line therapy for glaucoma—Prostaglandin analogs The “oprosts”—bimatoprost (Lumigan, Latisse for thick, long eyelashes), latanoprost (Xalatan), travoprost (Travatan, Travatan Z) Prostaglandin analogues—lower Intraocular pressure by 25-30%

5 Long-term use of topical prostaglandin analogs **Latisse (bimatoprost) for thick, long eyelashes Conjunctival hyperemia Darkening of the iris Increasing the length and number of eyelashes Iris pigment changes occur most frequently in patients with green-brown, yellow-brown, or blue-gray-brown irides

6 Vaginal monistat and warfarin Check the INR within 4 days of adding or subtracting any drug, regardless of the route of administration TELL your patients to let you know if they pick something up OTC Vaginal monistat can double the INR

7 Premarin vaginal cream/estrogen vaginal suppositories (Vagifem) If used within 2 hours of sex, can cross the male urethra and feminize the husband 98.7% of vaginal estrogen stays in the vagina; only 1.3% can be absorbed systemically—not enough to cause systemic side effects

8 Pre- and Post-menopausal females and hormones Use of a hormone patch does NOT increase fibrinogen or clotting factors Reduces risk of clotting complications Especially useful in smokers, overweight, and older women

9 Notes on “timing” of drugs Any drug that is given once a day works best in the first 12 hours—even tho’ drug “levels” are maintained throughout the 24 hour period (exception to rule, insulin glargine (Lantus) has a steady state for 24 hours) Once a day BP drugs—given in a.m.? Work best from 8 a.m. to 8 p.m. fine for most people; however, remember that BP rises fastest in the early a.m.—strokes and MIs Dippers vs. non-dippers BID dosing or give anti-HBP drug at bedtime

10 Notes on timing of drugs Proton Pump Inhibitors Give minutes before the first meal of the day or if given BID, give minutes before breakfast and dinner The PPIs STOP the acid pump that kicks in after you eat Giving the pill AFTER a meal defeats the purpose—the pump has already started

11 ASA at night Some new studies are showing that aspirin taken at night may decrease platelet aggregation in a.m. (American Heart Association Annual Meeting, November 2013) Separate low-dose aspirin from ibuprofen by 30 minutes)—don’t take together or the effect of aspirin on platelets will be negated (FDA Advisory, 9/2006)

12 Notes on OTC drugs OTC famotidine (Pepcid) is the best H2 blocker –less drug interactions, more acid suppression Double the recommended OTC dose on the box for the best results—remember that the H2 blockers work best at suppressing vagally- induced histamine—i.e. histamine produced overnight. So give Pepcid at hs

13 OTC Aspirin-- role in inflammation IN ADULTS: Preventing heart disease—arterial clots (not venous clots)—platelets play a major role in arterial clots, not DVTs Preventing colon polyps (triggered by production of prostaglandins) and other solid tumors; may also inhibit metastasis in cancer patients (Rothwell) Aspirin is no longer recommended for pain management or for hyperthermia

14 OTC herbal products SJW—interacts with 60% of all drugs and makes them LESS effective; dig, cyclosporin, tamoxifen, HAART, COCs…and the list continues… Ginseng—sodium and water retention with increased BP; estrogen-like properties (gynecomastia), platelet inhibition, (dysfunctional uterine bleeding in PMF, prolonged periods in younger women) Many herbal products elevate liver enzymes—KAVA, germander, skull cap, mistletoe, sassafras Many herbal products interfere with platelet aggregation—gingko, grapeseed extract, garlic, SJW

15 Generics vs. Brand names As a general rule, classes of drugs have the same generic “last” name “Statins”—Lower LDL-cholesterol “Prils”—ACE inhibitors (BP + more) “Triptans”—treatment of acute migraine headache “Sartans”—ARBs (angiotensin receptor blockers)—BP + more “Prazoles”—Proton Pump Inhibitors, GERD The “afils” – pulmonary hypertension The “conazoles”—antifungal The “olols”, “alols”, “ilols” “Dipines”—calcium channel blockers (BP+) The “coxibs”—COX-2 inhibitors The “cyclovirs”—antiherpetic drugs

16 The ACE inhibitors—the “prils” Captopril (Capoten)(1981) Enalapril (Vasotec)(1983) Fosinopril (Monopril) Lisinopril (Prinivil, Zestril) Perindopril (Aceon) Moexipril (Univasc) Benazepril (Lotensin) Quinapril (Accupril) Trandolapril (Mavik) Ramipril (Altace)

17 “Sartans”—Angiotensin II Receptor Blockers—the ARBS Angiotensin receptor blockers (bypass ACE) and work by blocking the angiotensin II receptors on tissues Who are they? The “Sartan Sisters”… losartan—Cozaar; yes, peds; 6 and over valsartan—Diovan—yes; 6 and over candesartan—Atacand—peds, yes. Ages 1 and over irbesartan—Avapro—peds, nope telmisartan—Micardis—no in kids olmesartan—Benicar; yes in kids eprosartan –Tevetan—peds? nope azilsartan – Edarbi; no kids

18 ACES and ARBS ACE inhibitors = ARBS for blood pressure control and they are both relatively safe. The side effect of angioedema is less likely with the ARBs. The ARBs may be better after a myocardial infarction, whereas both ACE inhibitors and ARBs protect after strokes. There is absolutely no evidence to support combining ACE inhibitors with ARBs. (American Society of Hypertension, March 2013)

19 Is there a “better” ACE inhibitor? Good question…yes, and it has nothing to do with reducing systemic blood pressure Evidence suggests that centrally acting ACE inhibitors (i.e. ramipril, trandolopril, captopril, fosinopril, and lisinopril), all cross the blood brain barrier (ie, lipid-soluble), and have been shown to slow cognitive decline in patients with dementia. (Gao Y et al. Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia. BMJ Open 2013 Jul 22)

20 Pediatric hypertension Primary hypertension in children has been shown to correlate with family history of hypertension, low birth weight, and excess weight. With the increasing prevalence of childhood weight problems, increased attention to weight- related health conditions including hypertension is warranted. And the weight is not just about blood pressure!

21 Pediatric Type 2 diabetes The incidence of Type 2 diabetes in kids is increasing exponentially There’s NO good news about this The combination of obesity and type 2 diabetes = more rapid progression to long- term side effects—HBP, CAD and … Progression to chronic kidney disease (CKD) much faster than kids with Type 1 diabetes

22 Three “prils” approved for kids over 6 Fosinopril (Monopril)—approved for kids over 6 and weight greater than 50 kg Lisinopril (Prinivil, Zestril)—kids 6 and over Benazepril (Lotensin)—kids 6 and over

23 New BP recommendations – primary (old name—essential) hypertension Chlorthalidone (Thalitone), amlodipine (Norvasc), and lisinopril (Prinivil, Zestril) all lower blood pressure equally and outcomes are similar between these three drugs (ALLHAT Study)

24 Chlorthalidone vs. HCTZ Chlorthalidone (Thalitone) is superior to hydrochlorothiazide (HCTZ); decreases cardiovascular risk Works in patients with lower glomerular filtration rates than HCTZ. HCTZ has no effect with GFRs less than 45 mL/min; chlorthalidone is okay with GFRs down to 30 mL/min. Downside: more hospitalizations for hypokalemia and hyponatremia with chlorthalidone vs. HCTZ. (Dhalla LA et al. Chlorthalitone vs. hydrochlorothiazide for the treatment of hypertension in older adults. Ann Intern Med 2013 Mar 19;158:447)

25 “Stacking” diuretics is the new trend When spironolactone is add-on therapy in CHF (chronic heart failure) patients, hyperkalemia is a high risk. If spironolactone is added to a diuretic that “wastes” potassium, the results improve—so chlorthalidone or furosemide can be stacked with spironolactone. Metazolone (Indapamide) can also be stacked with spironolactone in patients with a low GFR.

26 A note on the CCBs The majority of CCBs, including amlodipine (Norvasc) can cause significant peripheral edema (felodipine /Plendil is the worst offender) Irsradipine (DynaCirc) does not. Switch if the patient is non-compliant due to the edema. You can combine calcium channel blockers together— isradipine and verapamil for example but watch out for gingival hypertrophy. And always watch for constipation with verapamil—regardless of age

27 An interesting side effect of the CCBs Fertility issues

28 Beta-blockers no longer recommended for primary hypertension Beta-blockers have become obsolete for cardiovascular protection in hypertensive patients. Their “era” did not include percutaneous interventions, statins, platelet therapies and ACE inhibitors or Angiotensin Receptor Blockers (ARBs). Studies show that adding a beta-blocker to current anti-hypertensive therapies does NOT improve outcomes. P.S. beta blockers are still useful for nonhypertensive indications—like inhibition of remodeling in patients with systolic heart failure. (REACH Registry JAMA 2012;308:1340)

29 Beta-blockers All antihypertensive agents are NOT created equal…case in point—the beta blockers The beta blocker atenolol (Tenormin) is the worst of the bunch as a beta blocker used for hypertension. Atenolol raises the central blood pressure (the pressure experienced by the heart, brain, and kidneys) DESPITE lower brachial pressure. This paradoxical effect is a bad one. Atenolol has a risk ratio of 1.26 for cardiovascular disease compared to all of the other beta blockers.

30 Beta-blocker-plus drugs The beta-blocker “plus” drugs. The term means that beta blockade is accompanied by other important actions. Carvedilol (Coreg) provides alpha-one blocking effects with peripheral vasodilation. Nebivolol (Bystolic) also boosts nitric oxide production and is a potent vasodilator. As a result of the “plus” factor, carvedilol and nebivolol do not increase central blood pressure (as does Atenolol). So, choosing one of these as an “add-on” or first- line therapy for hypertension may be useful

31 Important clinical note… The ASCOT-LLA trial compared atorvastatin/placebo with atorvastatin/beta- blocker for cardioprotection. Significant endpoints were better in the statin-placebo group compared with the statin/beta-blocker group. The results suggest that the beta blockers interfere with the statins effects on cardiovascular protection.

32 What’s not to love about the ACE inhibitors?

33 Side effects, of course… Hypotension—start low and go slow Hypoglycemia (low blood sugar)—only in diabetics on antiglycemic agents; not a problem in normoglycemic patients; instruct your patients to carry some extra hard candy with them for any initial hypoglycemic episodes

34 Side effects, of course… Hyperkalemia (high potassium) (excreting sodium and water and retaining potassium) Add a thiazide diuretic to the ACE inhibitor Capozide (captopril + thiazide) Prinizide (lisinopril + thiazide) Zestorectic (as above) Lotensin HCT (benazepril + hydrochlorothiazide)

35 ACE, ARBs and serum creatinine levels Serum creatinine may rise 10% to 30% from baseline within the first two weeks of starting therapy with either an ACE inhibitor or ARB (angiotensin-receptor blocker). Pts with normal renal function starting either class of angiotensin blocking drugs experience a rise of about 0.2 mg/dL over a two- to three-week period, returning to baseline in the 4 th week. (Greene JH. Restricting dietary sodium and potassium intake: a dietitian’s perspective. In Daugirdas JT. Handbook of Chronic Kidney Disease Management. Philadelphia, PA: Lippincott Williams & Wilkins;2011:81-96)

36 ACE, ARBs and serum creatinine levels If the patient has renal insufficiency to begin with, expect a rise in serum creatinine of 0.5 mg/dL over a four-week period. Patients with renal artery stenosis, extensive atherosclerotic cardiovascular disease, or dehydration may experience a progressive increase in serum creatinine to 2.0 mg/dL. Discontinuing the ACE or the ARB is the appropriate course of action. (Greene JH. Restricting dietary sodium and potassium intake: a dietitian’s perspective. In Daugirdas JT. Handbook of Chronic Kidney Disease Management. Philadelphia, PA: Lippincott Williams & Wilkins;2011:81-96)

37 Since ACE inhibitors conserve potassium…What about K+ containing foods? May contribute to hyperkalemia and cardiac arrhythmias but usually only in patients with renal insufficiency or in patients who are also on K+ sparing diuretics such as spironolactone (Aldactone) and eplerenone (Inspra) Avoid excessive potassium intake when on the above drugs or with renal insufficiency Advise patients to decrease potassium intake until they can get their potassium checked

38 Risk factors for moderate hyperkalemia (≥ 5.6 mmol/L) Patients older than 65 CHF SCr greater than 1.6 mg/dL BUN greater than 18 mg/dL DOSING REDUCTION or D/C with the following: Hyperkalemia greater than 5.6 mmol/L Age greater than 70 BUN greater than 25 mg/dL Serum K+ greater than 6 mmol/L

39 High K+ containing foods≥200 mg/serving Avocado Artichoke Broccoli Carrots Cantaloupe Potatoes Dried beans, canned mushrooms Apricots Bananas Pumpkin Spinach Oranges for K+ content of 1,200 foods

40 Bummer. Unfortunately chocolate also fits into the category of high-potassium foods, as does peanut butter, nuts, seeds, milk, and yogurt. (Greene JH. Restricting dietary sodium and potassium intake: a dietitian’s perspective. In Daugirdas JT. Handbook of Chronic Kidney Disease Management. Philadelphia, PA: Lippincott Williams & Wilkins;2011:81-96)

41 Other potential K+ boosters… Check K+ level no later than one week after starting spironolactone (low risk patients check at 7 days; moderate and high risk patients check at 4 and 10 days, after a dose increase or if diuretic doses are increased) Stop taking any K+ supplements Go easy on the NSAIDS (decrease GFR) with retention of fluids and electrolytes Herbal or natural remedies with hefty doses of potassium include noni juice, Siberian ginseng, hawthorn berries, (Harvard Heart Letter, December 2004)

42 One last note…drugs and herbal products that increase potassium Don’t use Bactrim/Septra for UTIs when patients are on ACE inhibitors—it also increases K+ and can lead to life-threatening arrhythmias NSAIDS conserve K+ due to vasoconstriction of the afferent arteriole (ibuprofen, piroxicam, and naproxen are the biggest offenders) KCl supplements (as salt substitutes)

43 Side effects, continued… Cough (gender differences with F > M) ACE inhibitors block angiotensin converting enzyme; but as ACE is inhibited, bradykinin goes UP…bradykinin is a potent bronchospastic agent Women have more bradykinin to begin with, therefore the gender disparity in the cough

44 Side effects, continued… Life-threatening angioedema (“Does my voice sound funny to you?”) Usually within the first month (but not the first week); almost all cases within the first year An exception or two

45 ARBs as a safe haven for the side effects of the “prils” Are the “sartans” safe for patients with a history of angioedema from the “prils”? Appears to be about an 5 to 8% rate of cross- reactivity Given this limited percentage, switching to an ARB should not be considered an absolute contraindication in all patients with ACE-inhibitor induced angioedema Switch cautiously (Prescriber’s Letter 2004; 11(7))

46 ACE vs. ARB New and important info from American Society of Hypertension meeting 2013 All ACE are = in lowering BP ACE = ARB and both relatively safe; ARBs with less angioedema ARBs may be better after MI Both protect after strokes No evidence to support combing ACE + ARB

47 ACA/AHA new recommendations for prevention and treatment of high cholesterol The American College of Cardiology/American Heart Association guideline on the Treatment of Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults has been released and it basically uses the KISS method—KEEP IT SIMPLE, STUPID. In other words, instead of a plethora of cholesterol-lowering drugs, a long-list of recommendations, and never-ending caveats, the focus is now on just 4 at-risk groups: (P.S. this has stirred up quite the controversy)

48 The NEW recommendations for statin therapy 1) The so-called “secondary” prevention group consisting of individuals who have already experienced a cardiovascular event—TIA, PAD, Angina, ACS, ischemic stroke 2) The population of individuals with an LDL- cholesterol level of ≥190 mg/dL

49 New recommendations for statin therapy 3) Individuals with type 2 diabetes aged without a history of a prior cardiovascular event and a LDL-cholesterol level between 70 and 189 mg/dL, and,

50 New recommendations for statin therapy Individuals with a 10-year or greater risk of a cardiovascular event as calculated by the Cardiovascular Risk Calculator. Log on to the Framingham Heart Study online and click on the cardiovascular risk assessment calculator to determine risk. Based on blood pressure, gender, total cholesterol, and HDL cholesterol…so have all of that information handy to determine the likelihood of having a major coronary event in the next 10 years.

51 The #1 oral drug for Type 2 DM Metformin (Glucophage, Glucophage ER, Fortamet, Glumetza, Riomet ) (1995)--does not have any direct effect on insulin release from the pancreas—doesn’t require insulin to work—hypoglycemia is NOT a side effect Primary action: DECREASE hepatic glucose production; decreases glucose absorption via the GI tract, and increases insulin receptor sensitivity Problem? GI blues; need functioning organs--kidneys and heart especially (check serum creatinine before starting metformin; caution with heart failure) Se Creatinine--Cut-off is 1.4 (50-90 mmol/L) in females and 1.5 ( mmol/L) in males

52 Metformin (Glucophage,Glumetza, Fortamet, Glucophage ER) Metformin and breast and prostate cancer reduction (54%)—Diabetes Care December 2010 Metformin and slowing the aging process (slows down the shortening of telomeres + fish oil) Metformin and neurogenesis Metformin and anti-psychotic drugs and weight gain Metformin and HD-Prednisone and weight gain Metformin and NASH (Hepatology Vol. 55 (6): 2012) Metformin and PCOS

53 Downside to Metformin B12 deficiency (the peripheral neuropathy of diabetes may actually be due to a B12 deficiency neuropathy—give diabetics B12—improves any neuropathy they have) (have the patient take 1000 mcg B12 daily) Increase in BFR (basal flatal rate) Diarrhea (nighttime dosing, take with food; switch to long-acting metformin— glucophage ER, Glumetza, Fortamet) D/C for 48 hours after a contrast dye procedure

54 The “gliptins” Weight neutral Sitagliptin (Januvia) inhibits enzymes in the intestine responsible for breaking down incretins; What are incretins? Incretins are responsible for approx. 60% of the post-meal insulin secretion, but the action of the incretins is impaired in diabetics incretins potentiate insulin release Saxagliptin (Onglyza) Linagliptin (Tradjenta) Alogliptin (Nesina) Side Effects? acute pancreatitis (possible increased risk of pancreatic cancer????—not sure, diabetes increases your risk of pancreatic cancer as does chronic pancreatitis)

55 Better…oral drug combinations Metaglip (glipizide and metformin) Glucovance (glyburide and metformin) Janumet (sitagliptin and metformin) Kombiglyze (saxagliptin + metformin) Kazano (alogliptin + metformin) Sitagliptin (JANUVIA)+ simvastatin (ZOCOR)-- Juvisync More, more, more…

56 Incretin mimetics (April 28, 2005)— Remember: Incretins are responsible for approx. 60% of the post-meal insulin secretion, but the action of the incretins is impaired in diabetics) Exenatide (Byetta and Bydureon—longer lasting/once a week)—isolated from saliva of a Gila Monster—”lizard spit”.. Generally added on to Type 2 diabetics who are already receiving metformin, a sulfonylurea, or both and do not have optimal control

57 Incretin mimetics Acts at the GLP-1 receptor, promoting insulin release Weight loss is a + side effect (due to slowing of gastric emptying and “feeling full”) 2 nd generation—liraglutide (Victoza)--qd Bydureon (long-acting Byetta once a week) Better than Byetta as it reduces HgA1C 1.6% vs. 0.9% for Byetta Bydureon with weight loss greater than Byetta but less than liraglutide Bydureon nausea 14% vs. Byetta at 35%

58 The “prazoles”—Proton Pump Inhibitors* Who are they? Omeprazole (Prilosec)(first released as Losec in U.S., Losec* )—yes in kids for GERD Lansoprazole (Prevacid) –approved for kids 1 and over De X lansoprazole (old-Kapidex)(new-Dexilant) not in kids Rabeprazole (Aciphex)—kids 12 and older Pantoprazole (Protonix, Pantoloc*) Esomeprazole (Nexium)-- “the purple pill”—yes in kids based on weight or age BIG Exception: Aripiprazole/Abilify—antipsychotic—a dopamine system stabilizer

59 GER and GERD in kids GER is also called acid reflux or acid regurgitation because the stomach’s digestive juices contain acid. Infants with GER spit up liquid mostly made of saliva and stomach acids. GER is common in infants under 2 years of age. About half of all infants spit up, or regurgitate, many times a day in the first 3 months of life. Most healthy infants experience few to no symptoms and stop spitting up between the ages of 12 and 14 months.

60 GER and GERD in kids Gastroesophageal reflux disease (GERD) is a more serious, chronic—or long lasting—form of GER. If an infant’s GER progresses to GERD, additional symptoms—such as vomiting and poor feeding—occur and can adversely affect the child’s overall health and temperament. Infants with severe symptoms or with GER that lasts beyond 12 to 14 months may actually have GERD

61 The “prazoles”—Proton Pump Inhibitors MOA—Inhibition of the proton pump at the lumenal surface of the stomach … especially after a meal Parietal cell Lumenal surface Basilar surface H2 receptors H2 H+, Intrinsic Factor- B12 PPIs work here H2 blockers work here

62 The “prazoles” Work within 4-7 days to reduce all acid in the stomach; take 30’-60’ before the first meal of the day or before the dinner meal (especially if nocturnal GERD is a problem) BUT suppressing acid has been shown to have significant side effects: Increased risk of hospital-acquired pneumonia and community acquired pneumonia (PPI use might be associated with 33,000 preventable deaths due to pneumonia in hospitalized patients)(Herzig) Increased food-borne illness Iron deficiency anemia over the long term (need acid to absorb iron) Increased risk of B12 deficiency due to blocking the release of intrinsic factor

63 **Use of PPIs and clostridium difficile Daily PPI use associated with an estimated 74% increase in Clostridium difficile infection People using PPIs while being treated for C. difficile had a 42 % increased risk of recurrence Archives of Internal Medicine 2010;170: , Should all patients be put on PPIs upon admission to the hospital? NO, it’s NOT necessary…ICU patients? YES, because they have been shown to have the highest risk for a GI bleed from stress-induced gastric ulcers; but not for every bunionectomy, hemorrhoidectomy, or tonsillectomy

64 PPIs and Inappropriate subscribing in hospital patients Reid M et all. Inappropriate prescribing of proton pump inhibitors in hospitalized patients. J Hosp Med 2012 May/Jun 7:421 Herzig SJ et al. Acid-suppressive medication use and the risk for nosocomial gastrointestinal tract bleeding. Arch Intern Med 2011 Jun 13;171:991.

65 Clinical implications of B12 deficiency B12 is necessary for the healthy production of RBCs and for the maintenance of the central and peripheral nervous system (cognitive function in the CNS and motor/sensory function of spinal cord and peripheral nerves) B12 deficiency is the number one cause of nutritional dementia B12 deficiency is one of the top 3 causes of peripheral neuropathy in the elderly B12 deficiency causes macrocytic anemia (MCV greater than 120) B12 is stored in the liver for ~ 5 years—takes a long time of PPI use to cause B12 deficiency

66 Combine long-term use of PPIs with other risk factors… 39% of the population over 50 has a B12 deficiency Patients on glucophage (Metformin) for longer than 3 years should also have B12 levels measured Patients with malabsorption (kids with Crohn’s disease, celiac disease; gastrectomy; gastric by-pass surgery; atrophic gastritis Vegetarians, vegans

67 Should we all be taking B12? Keep B12 above 350 pg/mL (“normal range” – pg/mL If so, how can we take it? Supplements? The 4 S’s… How much? For dementia? Injections (patients with dementia and levels less than 300 pg/mL should be given a trial of B12); For peripheral neuropathy? For daily maintenance? Can you overdose on B12? The one dreaded side effect is…

68 Bibliography Annibale B, Capurso G, Delle Fave G. The stomach and iron deficiency anemia: a forgotten link. Dig Liver Dis 2003;35: Cayley WE. Are beta blockers effective first-line treatments for hypertension? Am Fam Phys 2007 Nov 1; 76(9); Gardiner P, Phillips R, Shaughnessy AF. Herbal and dietary supplement-drug interactions in patients with chronic illnesses. Am Fam Phys 2008 Jan 1; 77(1): Herzig SJ et al. Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA 2009 May 27;301:2120.

69 Bibliography Rothwell PM et al. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death. Lancet 2012 Mar 21. Rothewell PM et al. Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials. Lancet 2012, Mar 21. Tatro DS, ed. Drug Interaction Facts: Herbal supplements and Food. St. Louis, MO. A. Walters Kluwer Co; 2004; also available at

70 Bibliography Nisbet BC, O’Conner RE. Atypical presentation of ACE Inhibitor-Induced Angioedema. Resident and Staff Physician October 2007;53(9): Palmer M, Rosenbaum S. Clinical Practice Guideline of the American Academy of Emergency Medicine (AAEM); initial evaluation and management of patients presenting with acute urticaria or angioedema. l_practice_guidelines. l_practice_guidelines Tarascon Pocket Pharmacopoeia Deluxe edition. Davis’s Drug Guide for Nurses. 13 th edition F.A. Davis and Company, Philadelphia.

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