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Brian Marquardt and Dave Veltkamp Applied Physics Laboratory Center for Process Analytical Chemistry University of Washington Seattle, WA 98105 Combining.

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Presentation on theme: "Brian Marquardt and Dave Veltkamp Applied Physics Laboratory Center for Process Analytical Chemistry University of Washington Seattle, WA 98105 Combining."— Presentation transcript:

1 Brian Marquardt and Dave Veltkamp Applied Physics Laboratory Center for Process Analytical Chemistry University of Washington Seattle, WA 98105 Combining Analytical Sensors and NeSSI to Improve PAT

2 What is NeSSI? Industry-driven effort to define and promote a new standardized alternative to sample conditioning systems for analyzers and sensors Standard fluidic interface for modular surface-mount components Standard fluidic interface for modular surface-mount components Standard wiring and communications interfaces Standard wiring and communications interfaces Standard platform for micro analytics Standard platform for micro analytics

3 What does NeSSI Provide Simple Lego-like assembly Easy to re-configure Easy to re-configure No special tools or skills required No special tools or skills required Standardized flow components Mix-and-match compatibility between vendors Mix-and-match compatibility between vendors Growing list of components Growing list of components Standardized electrical and communication (Gen II) Plug-and-play integration of multiple devices Plug-and-play integration of multiple devices Simplified interface for programmatic I/O and control Simplified interface for programmatic I/O and control Advanced analytics (Gen III) Micro-analyzers Micro-analyzers Integrated analysis or smart systems Integrated analysis or smart systems

4 Where Does NeSSI Fit in the Lab Instrument/Sensor Interfaces Design standards make development simpler Design standards make development simpler Reduced toolset to be mastered Reduced sample variability to account for Calibration/validation built-in Calibration/validation built-in Consistent physical environment for measurement Stream switching and/or mixing allow generation of standards to match analytical requirements Reaction monitoring Microreactors and continuous flow reactors Microreactors and continuous flow reactors Batch reactors (with fast loop) Batch reactors (with fast loop) Sample Preparation Gas handling (mixing, generation, delivery) Gas handling (mixing, generation, delivery) Liquid handling (mixing, dilution, conditioning, etc.) Liquid handling (mixing, dilution, conditioning, etc.)

5 The NeSSI Could Become the Base for a Micro-Analytical Lab A DEVELOPMENT PLATFORM

6 NeSSI with an Array of Micro- Analytical Techniques will Impact Many Industries Process Control Process Optimization Product Development

7 Sensing Technologies Gas Chromatography Thermal Desorption (?) Thermal Desorption (?) Dielectric () Spectroscopies IR (+), NIR (+) IR (+), NIR (+) UV- Vis (+) UV- Vis (+) Raman () Raman () Fluorescence (+) Fluorescence (+) Impedance (+) Conductivity () Refractive Index () Vapochromic Sensors (+) GLRS (+) Particle Sizing Light scattering (?) Light scattering (?) Turbidity (+) pH () RGA (+) Mass Spectrometry () LC, SEC, IC (+) Terrahertz (?)

8 NeSSI: Enabler for MicroAnalytical (the rail concept) Standard Mechanical Interface Rail Standard Electrical (Digital) Interface Rail Anyones Sensor Anyones Actuator SAM* Standard hockey-puckPC P V *Sensor/Actuator Manager Standard connectivity What technologies are available Suitability for modular sampling systems

9 Phased Micro Gas Analyzer

10 Substrate On/Off and Modulating valves Flow Sensor w/ Temp, Pressure w/ Temp Substrate Moisture in Dry Gases PHASED * Micro GC Other Analytical: Ion, Nox. O 2, pH Conductivity, NOx, Turbidity, Density, Opacity Refractive Index, OthersChemometric Sensors for Complex Analytical Measurements. Mod Valve D/A Network Press/ Temp A/D Network *PHASED: Courtesy of Honeywell PHASED microGC

11 MICRO-GC SLS GCM 5000 < 20 W Power 3 x 2 x 0.6 inches 100 gm / 3 oz. www.slsmt.com

12 ABB Natural Gas Chromatograph Analysis section contains stream selection solenoids, pressure regulation, 32 bit digital detector electronics and a dual-train chromatograph in a single, replaceable module (coffee-cup sized) Dimensions: 6.75 dia. × 16'' long × 9.00'' tall Weight: Approximately 28 lb. (12.7 Kg)

13 Siemens microSAM GC Valveless live injection with software-adjustable injection volume Maintenance-free column switching and electronic pressure control Accurate measuring results by multiple parallel micro- detectors Can be mounted directly at the sample extraction point because only a single auxiliary gas and very little electrical power is required Simple remote control with Windows-based software and Ethernet communication

14 Agilent 3000 Micro GC Custom configurations with 1 to 4 replaceable chromatographic channels. Choose from various micro- machined injectors, columns, sample conditioners, and application-specific reports. The modular GC design maximizes uptime, with repair as simple as exchanging one module for another. Increase sensitivity, maintain high precision, remove unwanted contaminants from your sample, or speed up analysis with variable, fixed or backflush injection options. Digital pneumatics control carrier gas flow electronically, enhancing reliability and precision while further simplifying operation. Dimensions: 5.9 x 9.8 x 16.1 Wt: 18 – 37 lbs (portable)

15 Applied Analytics Inc. Diode Array OMA-300 A Fiber-optics-diode- array process analyzer For on-line concentration monitoring

16 Applied Analytics Microspec IR FEATURES Ideal for monitoring PPM level WATER in various solvents In stream quantitative measurements Contains no moving parts and Extremely robust allowing for installations in process stream environments Replaces analyzers such as process spectrometers in the process plant.

17 NeSSI IR Gas Cell

18 Removable Tip Version Sentelligence Current NIR Sensors Sentelligence Current NIR Sensors - NIR Sensors

19 IR Microsystems Microarray 64 Board Dimensions: 66 x 53 mm 2 Board Dimensions: 66 x 53 mm 2 Wilks Enterprise InfraSpec Variable Filter Array

20 Agilent NeSSI Dielectric Sensor Cable to Agilent Network Analyzer Swagelok 2-Port Valve Base Dielectric Probe Inner Body O-ring (inside) Outer Body Exploded View Close up of Coaxial Probe Tip

21 Liquid Chromatography for NeSSI micromixer diluent in column mobile phase in sample in Scott Gilbert, CPAC Visiting Scholar Crystal Vision Microsystems LLC Atofluidic Technologies, LLC Split flow approach to sampling -fluidic LC Chip for On-line Sample Pretreatment -fluidic LC Chip for On-line Sample Pretreatment Pulsed electrochemical detection (on-chip) Liters per minute microliters per minute nanoliters per minute

22 Aspectrics EP-IR with Gas Cell Glow source Gas cell Spectrometer 15 7 5.2

23 Interfacing NeSSI to ASI microFast GC Complete gas/vapor sensing test platform on the bench top Gas delivery, vapor generation, and blending in NeSSI Real time verification of composition using GC and EP-IR Easily extended to include other analytical and sample treatments Vapochromic sensor optical cell GC sipper port EP-IR gas cell

24 NeSSI System for Gas/Vapor Generation and Sensor Calib.

25 CPAC Funded Technology Developments

26 Development of a Micro-NMR System NMR spectrum of a 3 micro liter water sample using a RF micro-coil M. McCarthy, UC Davis

27 Spreeta SPR sensing components Each Spreeta chip contains all of the optical components needed for sensitive SPR measurement of biomolecular interactions SPIRIT system performs SPR detection using Texas Instruments Spreeta SPR chips Chips are mass-produced by TI, cost ~$4 in large quantities Each chip can perform three simultaneous measurements Systems contain 8 chips, for 24 total sensing channels Clem Furlong, et al, UW

28 Fringing Field Dielectric NeSSI Sensor Alex Mamishev EE and Marquardt CPAC, UW

29 Raman/NIR/UV-Vis Sensor Module

30 NeSSI Raman Sampling Block Reactor NeSSI substrate Sample conditioning to induce backpressure to reduce bubble formation and the heated substrate allows analysis at reactor conditions

31 PtO 2 NeSSI Sensor Fiber optic cable to Ocean Optics Spectrometer Swagelok 2-Port Valve Base Fiber- optic Probe(405 nm LED) Inner Body O-ring (inside) Outer Body Exploded View Close up of Outer Body Tip VapochromicT ip

32 Calibrated Gas Generation

33 Application of Permeation Apparatus

34 Acknowledgments Center for Process Analytical Chemistry Students – Charles Branham and Wes Thompson, UW Professor Kent Mann, Univ. of Minnesota Clem Furlong – UW Medical Genetics Mike McCarthy and group – UC Davis Scott Gilbert – UW Visiting scholar Swagelok, Parker and Circor ABB, Agilent, Aspectrics, Honeywell, ExxonMobil


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