Presentation on theme: "Combining Analytical Sensors and NeSSI to Improve PAT"— Presentation transcript:
1 Combining Analytical Sensors and NeSSI to Improve PAT Brian Marquardt and Dave VeltkampApplied Physics LaboratoryCenter for Process Analytical ChemistryUniversity of WashingtonSeattle, WA 98105
2 What is NeSSI™?Industry-driven effort to define and promote a new standardized alternative to sample conditioning systems for analyzers and sensorsStandard fluidic interface for modular surface-mount componentsStandard wiring and communications interfacesStandard platform for micro analytics
3 What does NeSSI™ Provide Simple “Lego-like” assemblyEasy to re-configureNo special tools or skills requiredStandardized flow components“Mix-and-match” compatibility between vendorsGrowing list of componentsStandardized electrical and communication (Gen II)“Plug-and-play” integration of multiple devicesSimplified interface for programmatic I/O and controlAdvanced analytics (Gen III)Micro-analyzersIntegrated analysis or “smart” systems
4 Where Does NeSSI™ Fit in the Lab Instrument/Sensor InterfacesDesign standards make development simplerReduced toolset to be masteredReduced sample variability to account forCalibration/validation built-inConsistent physical environment for measurementStream switching and/or mixing allow generation of standards to match analytical requirementsReaction monitoringMicroreactors and continuous flow reactorsBatch reactors (with fast loop)Sample PreparationGas handling (mixing, generation, delivery)Liquid handling (mixing, dilution, conditioning, etc.)
5 The NeSSI Could Become the Base for a Micro-Analytical Lab ‘A DEVELOPMENT PLATFORM’
6 NeSSI with an Array of Micro-Analytical Techniques will Impact Many Industries Process ControlProcess OptimizationProduct Development
7 Sensing Technologies Vapochromic Sensors (+) Gas Chromatography GLRS (+)Particle SizingLight scattering (?)Turbidity (+)pH (√)RGA (+)Mass Spectrometry (√)LC, SEC, IC (+)Terrahertz (?)Gas ChromatographyThermal Desorption (?)Dielectric (√)SpectroscopiesIR (+), NIR (+)UV- Vis (+)Raman (√)Fluorescence (+)Impedance (+)Conductivity (√)Refractive Index (√)
8 NeSSI™: Enabler for MicroAnalytical Standard“connectivity”(the “rail” concept)Standard Electrical (Digital) Interface “Rail”SAM*PVStandard“hockey-puckPC”Anyone’s SensorAnyone’s ActuatorIt is really about creating a set of standard interfaces, so current and new analytical devices and sample system components can be quickly and easily integrated into the process environment.A standard electrical interface that will provide power, a standard communication format, and standard protocol between these devices.A standard software package that will allow for inter device communication, control, and diagnostics at the installation level. And a standardized portal and protocol for communication with the plant DCS or Enterprise Management System.A standard mechanical interface. A standardized footprint for interfacing these devices and components with the process sample.Standard Mechanical Interface “Rail”*Sensor/Actuator ManagerWhat technologies are availableSuitability for modular sampling systems
10 PHASED microGC D/A A/D Mod Valve Press/ Temp Other Analytical: Ion, Nox. O2, pHConductivity,NOx, Turbidity,Density, OpacityRefractive Index,OthersChemometricSensors forComplex AnalyticalMeasurements.NetworkNetworkD/AA/DModValvePress/TempSubstrateSubstrateSubstrateOn/Off and Modulating valvesFlow Sensor w/ Temp, Pressure w/ TempPHASED * Micro GCMoisture in Dry Gases*PHASED: Courtesy of Honeywell
11 MICRO-GC SLS GCM 5000 < 20 W Power 3 x 2 x 0.6 inches 100 gm / 3 oz.
12 ABB Natural Gas Chromatograph Dimensions: 6.75“ dia. × 16'' long × 9.00'' tallWeight: Approximately 28 lb. (12.7 Kg)Analysis section contains stream selection solenoids, pressure regulation, 32 bit digital detector electronics and a dual-train chromatograph in a single, replaceable module (coffee-cup sized)
13 Siemens microSAM GCValveless live injection with software-adjustable injection volumeMaintenance-free column switching and electronic pressure controlAccurate measuring results by multiple parallel micro-detectorsCan be mounted directly at the sample extraction point because only a single auxiliary gas and very little electrical power is requiredSimple remote control with Windows-based software and Ethernet communicationi.e. MicroSAM uses a thermal conductivity detector array integrated on silicon to measure all column and vent flows as well as the injection peak itself
14 Agilent 3000 Micro GCDimensions: 5.9” x 9.8” x 16.1” Wt: 18 – 37 lbs (portable)Custom configurations with 1 to 4 replaceable chromatographic channels. Choose from various micro-machined injectors, columns, sample conditioners, and application-specific reports.The modular GC design maximizes uptime, with repair as simple as exchanging one module for another.Increase sensitivity, maintain high precision, remove unwanted contaminants from your sample, or speed up analysis with variable, fixed or backflush injection options.Digital pneumatics control carrier gas flow electronically, enhancing reliability and precision while further simplifying operation.
15 Applied Analytics Inc. Diode Array OMA-300A Fiber-optics-diode-array process analyzerFor on-line concentration monitoring
16 Applied Analytics Microspec IR FEATURESIdeal for monitoring PPM level WATER in various solventsIn stream quantitative measurementsContains no moving parts andExtremely robust allowing for installations in process stream environmentsReplaces analyzers such as process spectrometers in the process plant.
18 Sentelligence Current NIR Sensors Removable TipVersion- NIR Sensors
19 IR Microsystems Microarray 64 Board Dimensions: 66 x 53 mm 2Wilks Enterprise InfraSpec Variable Filter Array
20 Agilent NeSSI Dielectric Sensor Cable to Agilent Network AnalyzerDielectric ProbeClose up of Coaxial Probe TipInner BodyO-ring (inside)Swagelok 2-Port Valve BaseOuter BodyExploded View
21 Liquid Chromatography for NeSSI™ Scott Gilbert, CPAC Visiting Scholar Crystal Vision Microsystems LLC Atofluidic Technologies, LLCSplit flow approach to samplingm-fluidic LC Chip for On-line Sample PretreatmentPulsed electrochemicaldetection (on-chip)Liters per minutemicromixerdiluent incolumnmobile phase insample inmicroliters per minutenanoliters per minute
22 Aspectrics EP-IR with Gas Cell 15”7”Spectrometer5.2”Gas cellGlow source
23 Interfacing NeSSI™ to ASI microFast GC™ GC sipper portEP-IR gas cellVapochromic sensor optical cellComplete gas/vapor sensing test platform on the bench topGas delivery, vapor generation, and blending in NeSSI™Real time verification of composition using GC and EP-IREasily extended to include other analytical and sample treatments
24 NeSSI System for Gas/Vapor Generation and Sensor Calib.
26 Development of a Micro-NMR System NMR spectrum of a 3 micro liter water sample using a RF micro-coilM. McCarthy, UC Davis
27 Spreeta SPR sensing components SPIRIT system performs SPR detection using Texas Instruments’ Spreeta SPR chipsChips are mass-produced by TI, cost ~$4 in large quantitiesEach chip can perform three simultaneous measurementsSystems contain 8 chips, for 24 total sensing channelsIn the SPIRIT system, SPR is detected using mass-produced Spreeta sensing components manufactured by Texas Instruments. Each chip contains a complete optical system, including LED light sources, a molded plastic prism, a gold-coated sensor chip, and a diode array detector. Each chip provides three sensing channels( 200 μ-wide gold stripes); the SPIRIT system contains eight chips, for a total of 24 sensing channels.Each Spreeta chip contains all of the optical components needed for sensitive SPR measurement of biomolecular interactionsClem Furlong, et al, UW
28 Fringing Field Dielectric NeSSI Sensor Alex Mamishev EE and Marquardt CPAC, UW
34 Acknowledgments Center for Process Analytical Chemistry Students – Charles Branham and Wes Thompson, UWProfessor Kent Mann, Univ. of MinnesotaClem Furlong – UW Medical GeneticsMike McCarthy and group – UC DavisScott Gilbert – UW Visiting scholarSwagelok, Parker and CircorABB, Agilent, Aspectrics, Honeywell, ExxonMobil