2 Our product range They are mineral salts: Mineral/cation¹ Anion² FURDENTYLOur product rangeThey are mineral salts:(Ca, Zn, …)¹ (Glycerophosphate, nitrate, …)²FURDENTYL™FURDENTYL CZnFURDENTYL NKFURDENTYL ASrFURDENTYL CSrAgainst Dentinal hypersensitivity
3 FURDENTYL™FURDENTYL™ is a Calcium glycerophosphate (CaGP) (US GRAS approved)It has a cariostatic action and a role as a nutritional supplementIt can be used alone for its intrinsic anticaries activity or combined with NaMFP for its enhancing effect on the anticaries activity of fluorineFURDENTYL™ can be used:Locally: Toothpaste, mouthwash, chewing gum, before & after brushing solutionsOrally: Tablets
4 FURDENTYL™ Biological interests of the Glycerophosphate anion: An organic anionA mineral element vectorHas a special biological role in the body’s essential metabolic reactionsBecause of its combination with calcium, an appraisal of the anion’s intrinsic biological properties can be made.Cariostatic activityRole in the membrane cell and vital organs (especially the brain) tissues constitutionHence FURDENTYL role as a nutrient besides its anticaries action.
5 FURDENTYL™ FURDENTYL action mode: Being a nutrient & a cariostatic agent renders FURDENTYL particularly interesting in the case of individuals whose intellect and physique are still developing, such as teenagers and children.Dental caries is an infection, usually bacterial in origin, that causes demineralization of the hard tissues (enamel, dentin and cementum) and destruction of the organic matter of the tooth, usually by production of acid by hydrolysis of the food debris accumulated on the tooth surfaceFURDENTYL action mode:Acts as a buffer power against the saliva’s pHHelps mineralizing the tooth (Ca & P supplement)Improves the fluorine fixationImproves NaMFP’s role
6 FURDENTYL™ Tests Subjects: 923 children (11-12 years old) Design: Double blind studyToothpaste:Control group: Calcium carbonateActive control group: calcium carbonate + 0,76% NaMFP + 0,13 % CaGPThe fluorine concentration in each toothpaste is 1 ppmDuration: 4 yearsResults:Clinical examination of the teeth (optic fibre)X-rays of molar & premolar teethExamination once a yearResults at the end of the 4 years
7 FURDENTYL™ Clinical examination X-ray examination Group treated with CaGP/NaMFP combination has a greater cariostatic activityAn improvement in the NaMFP performance is observed when used with CaGPDFS: Decayed & Filled SurfacesX-ray examination
8 FURDENTYL™A decrease in the enamel dissolution is observed when NaMFP is combined with CaGPThe fluorine hydroxyapatite content is greater in the group treated by the combinationOptimal ratio : CaGP/NaMFP = 10:1
9 FURDENTYL™ Physical appearance: A white amorphous or crystalline powder, odorless & tastelessA white powder, acidified by 15% citric acid content, with a slightly acid taste & alcoholic smellA clear slightly syrupy liquid , with a light acid taste and an alcoholic smell (a 50% calcium glycerophosphate liquid)Quality-Pharmacopoeia:FURDENTYL powder: BPC 1963, FCC III, JP 8, NF X,PF XFURDENTYL acidified powder: with a 15% citric acid content: pharmaceutical gradeFURDENTYL 50% aqueous solution: Neutral calcium glycerophosphate + acidified calcium glycerophosphate + free glycerophosphoric acid: pharmaceutical grade
10 FURDENTYL ZnCFURDENTYL ZnC (Zinc citrate) is considered a safe and appropriate ingredient for tartar control and antigingivitis oral care products and has a history of use as a dietary supplementTartar forms in the mouth when plaque mineralizes on your teeth. The resulting hard deposits (calcified plaque or tartar) can only be removed by a dentist or hygienist.Zinc citrate helps prevent tartar buildup by preventing plaque from hardening (calcifying).Gingivitis is a disease of the gums that occurs when bacteria accumulate on teeth, producing toxins and irritants that lead to red, puffy gums. If left untreated, gingivitis can result in tooth loss and other health problems.Zinc citrate helps prevent gingivitis by inhibiting bacterial accumulation on teeth and gums.
11 Dentinal hypersensitivity Dentine hypersensitivity is sensation felt when the nerves inside the dentin of the teeth are exposed to the environment.The sensation can range from irritation all the way to intense, shooting pain. This sensitivity can be caused by several factors, including wear, decaying teeth or exposed tooth roots.This hydrodynamic flow can be increased by cold, air pressure, drying, sugar, sour (dehydrating chemicals), or forces acting onto the tooth.Hot or cold food or drinks, and physical pressure are typical triggers in those individuals with teeth sensitivity.Dentine contains many thousands of microscopic tubular structures that radiate outwards from the pulp; these dentinal tubules are typically micrometres in diameter.Changes in the flow of the plasma-like biological fluid present in the dentinal tubules can trigger mechanoreceptors present on nerves located at the pulpal aspect thereby eliciting a pain response.C’est normal que tout soit superposé. Cela ne le sera pas en mode diaporama.
12 Dentinal hypersensitivity The most cheap & efficient first line of treatment is a toothpaste containing a desensitizing active ingredient such as:Potassium NitrateStrontium ChlorideStrontium Acetate
13 Potassium Nitrate“The most widely used active ingredient in desensitizing toothpaste”Potassium ions work by blocking the synapse between nerve cells, reducing nerve excitation, and the associated pain.Potassium Nitrate is also reported to obliterate the tubules, reducing the fluid flow in them, ultimately reducing dentin hypersensitivity.
14 FURDENTYL SrA & SrCFURDENTYL SrC (Strontium Chloride) forms a barrier over microscopic tubules in the dentin containing nerve endings that have been exposed by gum recession.FURDENTYL SrA (Strontium Acetate) works by providing a physical plug within the microscopic channels which helps to prevent the response to triggers which can cause the short, sharp pain of sensitive teeth.
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