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Oral Care. Mineral/ cation¹ Anion² FURDENTYL mineral salts They are mineral salts: (Ca, Zn, …)¹ (Glycerophosphate, nitrate, …)² 2 Our product range FURDENTYL.

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Presentation on theme: "Oral Care. Mineral/ cation¹ Anion² FURDENTYL mineral salts They are mineral salts: (Ca, Zn, …)¹ (Glycerophosphate, nitrate, …)² 2 Our product range FURDENTYL."— Presentation transcript:

1 Oral Care

2 Mineral/ cation¹ Anion² FURDENTYL mineral salts They are mineral salts: (Ca, Zn, …)¹ (Glycerophosphate, nitrate, …)² 2 Our product range FURDENTYL FURDENTYL CZn FURDENTYL NK FURDENTYL ASr FURDENTYL CSr Against Dentinal hypersensitivity

3 FURDENTYL is a Calcium glycerophosphate (CaGP) (US GRAS approved) It has a cariostatic action and a role as a nutritional supplement It can be used alone for its intrinsic anticaries activity or combined with NaMFP for its enhancing effect on the anticaries activity of fluorine FURDENTYL FURDENTYL can be used: Locally:Locally: Toothpaste, mouthwash, chewing gum, before & after brushing solutions Orally:Orally: Tablets 3 FURDENTYL

4 Biological interests of the Glycerophosphate anion: An organic anion A mineral element vector Has a special biological role in the bodys essential metabolic reactions Because of its combination with calcium, an appraisal of the anions intrinsic biological properties can be made. Cariostatic activity Role in the membrane cell and vital organs (especially the brain) tissues constitution FURDENTYL Hence FURDENTYL role as a nutrient besides its anticaries action. 4 FURDENTYL

5 Being a nutrient & a cariostatic agent renders FURDENTYL particularly interesting in the case of individuals whose intellect and physique are still developing, such as teenagers and children. Dental caries is an infection, usually bacterial in origin, that causes demineralization of the hard tissues (enamel, dentin and cementum) and destruction of the organic matter of the tooth, usually by production of acid by hydrolysis of the food debris accumulated on the tooth surface FURDENTYL action mode: Acts as a buffer power against the salivas pH Helps mineralizing the tooth (Ca & P supplement) Improves the fluorine fixation Improves NaMFPs role 5 FURDENTYL

6 Tests Subjects Subjects: 923 children (11-12 years old) Design: Design: Double blind studyToothpaste: Control group: Calcium carbonate Active control group: calcium carbonate + 0,76% NaMFP + 0,13 % CaGP The fluorine concentration in each toothpaste is 1 ppm Duration Duration: 4 yearsResults: Clinical examination of the teeth (optic fibre) X-rays of molar & premolar teeth Examination once a year Results at the end of the 4 years 6 FURDENTYL

7 Group treated with CaGP/NaMFP combination has a greater cariostatic activity An improvement in the NaMFP performance is observed when used with CaGP DFS: Decayed & Filled Surfaces 7 FURDENTYL Clinical examination X-ray examination

8 A decrease in the enamel dissolution is observed when NaMFP is combined with CaGP The fluorine hydroxyapatite content is greater in the group treated by the combination Optimal ratio : CaGP/NaMFP = 10:1 8 FURDENTYL

9 Physical appearance: A white amorphous or crystalline powder, odorless & tasteless A white powder, acidified by 15% citric acid content, with a slightly acid taste & alcoholic smell A clear slightly syrupy liquid, with a light acid taste and an alcoholic smell (a 50% calcium glycerophosphate liquid) Quality-Pharmacopoeia Quality-Pharmacopoeia: FURDENTYL powder FURDENTYL powder: BPC 1963, FCC III, JP 8, NF X,PF X FURDENTYL acidified powder FURDENTYL acidified powder: with a 15% citric acid content: pharmaceutical grade FURDENTYL 50% aqueous solution: FURDENTYL 50% aqueous solution: Neutral calcium glycerophosphate + acidified calcium glycerophosphate + free glycerophosphoric acid: pharmaceutical grade 9 FURDENTYL

10 FURDENTYL ZnC tartar control and antigingivitis dietary supplement FURDENTYL ZnC (Zinc citrate) is considered a safe and appropriate ingredient for tartar control and antigingivitis oral care products and has a history of use as a dietary supplement Tartar Tartar forms in the mouth when plaque mineralizes on your teeth. The resulting hard deposits (calcified plaque or tartar) can only be removed by a dentist or hygienist. Zinc citrate helps prevent tartar buildup by preventing plaque from hardening (calcifying). Gingivitis Gingivitis is a disease of the gums that occurs when bacteria accumulate on teeth, producing toxins and irritants that lead to red, puffy gums. If left untreated, gingivitis can result in tooth loss and other health problems. Zinc citrate helps prevent gingivitis by inhibiting bacterial accumulation on teeth and gums. 10 FURDENTYL ZnC

11 cold, air pressure, drying, sugar, sour forces acting onto the tooth This hydrodynamic flow can be increased by cold, air pressure, drying, sugar, sour (dehydrating chemicals), or forces acting onto the tooth. Hot or cold food or drinks, and physical pressure Hot or cold food or drinks, and physical pressure are typical triggers in those individuals with teeth sensitivity. 11 Dentinal hypersensitivity Dentine hypersensitivity Dentine hypersensitivity is sensation felt when the nerves inside the dentin of the teeth are exposed to the environment. wear, decaying teeth or exposed tooth roots. The sensation can range from irritation all the way to intense, shooting pain. This sensitivity can be caused by several factors, including wear, decaying teeth or exposed tooth roots. Dentine contains many thousands of microscopic tubular structures that radiate outwards from the pulp; these dentinal tubules are typically micrometres in diameter. Changes in the flow trigger mechanoreceptors present on nerves a pain response Changes in the flow of the plasma-like biological fluid present in the dentinal tubules can trigger mechanoreceptors present on nerves located at the pulpal aspect thereby eliciting a pain response.

12 The most cheap & efficient first line of treatment is a toothpaste containing a desensitizing active ingredient such as: Potassium Nitrate Strontium Chloride Strontium Acetate 12 Dentinal hypersensitivity

13 The most widely used active ingredient in desensitizing toothpaste Potassium ions Potassium ions work by blocking the synapse between nerve cells, reducing nerve excitation, and the associated pain. Potassium Nitrate dentin hypersensitivity Potassium Nitrate is also reported to obliterate the tubules, reducing the fluid flow in them, ultimately reducing dentin hypersensitivity. 13 Potassium Nitrate

14 FURDENTYL SrC (Strontium Chloride) FURDENTYL SrC (Strontium Chloride) forms a barrier over microscopic tubules in the dentin containing nerve endings that have been exposed by gum recession. FURDENTYL SrA (Strontium Acetate) FURDENTYL SrA (Strontium Acetate) works by providing a physical plug within the microscopic channels which helps to prevent the response to triggers which can cause the short, sharp pain of sensitive teeth. 14 FURDENTYL SrA & SrC


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