Presentation on theme: "CELL-tainer® Single use Bioreactor"— Presentation transcript:
1 CELL-tainer® Single use Bioreactor November 2013CellD20bis, rue du ChapitreF ROQUEMAURETel : +33 (0)Fax : +33 (0)
2 CELL-tainer®A new single-use bioreactor with two-dimensional movement that offers superior mass transfer rates and short mixing times with low shear for high density cell culture and microbial fermentation
3 Features MASS-transfer & mixing Two dimensional rocking improves mixing and oxygen transferProper and accurate temperature controlHeating by convection (incubator)Direct cooling (heat exchanger under the bag)Short mixing times => no gradientsEASY handling & real single useBags flexible in volumeRobust design (stackable)In-line measurements non-invasive,fully disposable (pH, DO,), bottom mounted,others (glucose/lactate)ScaleableSame process performance at different scales
4 Features Complete system Incubator chamber Integrated process controls with HMI touchscreen21 CFR part 11 compliantPLC controller for rpm, pH, DO, Temp3 x Gas flow metersPressure gauges2 x Addition pumpsHeavy duty motorRemovable bag tray4
7 BenefitsPre-sterilized and disposable Reduce handling Plug and play operation Quick change over Expansion in a single bag = Minimize contamination risk Reduce variability Save time and labor Cycle time reduction Cost effective
9 kla-value at different rocking speeds The kla-value determined with the dynamic gassing in/out method including the off-gas analysis.At the 20 L CELL-tainer, optimal filling volumes are above 8L, rocking speeds above 25 rpm.At the 200 L CELL-tainer, the optimal filling volume ranges between 90 and 130L. At rocking speeds between 15 and 25 rpm, highest kla-values of 400 h-1 are obtained.
10 Cultivation results 12 L 120 L Cultivation of E. coli (Fed-batch): Final cell dry mass concentration of 45 gL-1 (OD=140) obtained in 35 h.(Junne et al, ChemieIngenieurTechnik Vol )
15 CELL-tainer® 200L single-use bag Mammalian: 5L – 200L working volume Microbial: 5L – 120L working volumeCONFIDENTIAL15
16 Service Support 1 Year Manufacturer’s Warranty Covers mechanical and electronic parts not subject to wear and tear (excluding labor and travel)Service support24 hour response with phone/ support to troubleshoot and diagnose problemIf issue is not resolved, an engineer will schedule on-site visit for servicingAnton Tromper -Ruben Engelhart -Lexan Lhu –Spare partsStocked at Charter Medical and available to ship FedEx next dayOptional add-on services / productsMaintenance contract -Site Acceptance Test (at customer site) - one day for CT20 and 2 days for CT200, excluding travelOperational training (at customer site) - one day for CT20 and 2 days for CT200, excluding travelCELL-tainer DACS software for one CELL-tainer including 1 Modbus licenseModbus license for connecting additional CELL-tainer (up to 8)HMI license for connecting additional CELL-tainer (up to 8)CONFIDENTIAL
17 THANK YOU For More Information: www.CharterMedical.com Contact Info:Dominique GhozlanCellD20bis, rue du ChapitreF ROQUEMAURETel : +33 (0)Fax : +33 (0)
Your consent to our cookies if you continue to use this website.