1. Research Tools Brought to you by the Clinical and Translational Science Institute Presented by: Terri Shkuda Systems Analyst Research Informatics The Penn State Clinical & Translational Research Institute, Pennsylvania State University CTSA, NIH/NCATS Grant Number UL1 TR000127

2. Clinical Translational Science Institute (CTSI) Funded by the NIH Goal: to develop, implement and provide, new methods to predict, prevent and effectively treat human disease. PSU’s CTSI supports researchers with a set of tools to accomplish these goals. 8/11/152

3. Research tool continuum Hypothesis Collaboration Data capture Analysis Publication i2b2 Cohort Discovery Tool Research Networking Electronic Data Capture Statistics 38/11/15

4. 4 i2b2’s Fundamental Purpose Cohort identification - Users search a de-identified database, to determine the existence of a set of unique patients meeting specified criteria. The dataset contains de-identified data for over 680,000 unique patients, from our EMR, billing systems and other smaller datasets including: Demographics ICD-9 diagnosis and procedures Lab tests Medications Visit types (inpatient, outpatient, emergency, etc.) Cancer staging Biorepository sample availability Dates associated with each event above There is NO IRB approval needed for access to this dataset.

5. Typical i2b2 Scenario Query database to see if there is a relationship between iron deficiency anemias and mood disorders. 8/11/155

6. i2b2 Additional Tools Once the cohort has been established… ◦ Demographics visualization tool ◦ Timeline tool for visualizing the timing of the events of the concepts ◦ Export tool for exporting data existing in i2b2. 8/11/156

7. REDCap – Electronic Data Capture for Research Create forms for data entry and surveys Surveys delivered to participants electronically Reuse of forms for multiple events/arms for repeated measures such as lab results Data export to common statistical packages with de-identification tools Data import from Excel; great for retrospective chart reviews Real time quality rule checks and post collection data query resolution 8/11/157

8. Exports to most common statistical packages De-identification Options o Automatic removal of pre-specified identifiers, selected by you during data capture but not relevant to analysis o Date Shifting Develop quick reports for quality control Reporting & Exporting Data 8/11/158

9. Security & Integrity Audit logs Role-based user rights Regularly scheduled network security scans Data stored in the Data Center and backed up nightly 8/11/159

10. REDCap Demo Scenario ◦ Create a longitudinal project containing surveys using a template ◦ Modify a form ◦ Enter data ◦ Send a survey invitation ◦ Record Status Dashboard 8/11/1510

11. Profiles Profiles is a research networking and expertise mining software tool to search faculty information containing: ◦ Name ◦ Title ◦ Affiliations ◦ Contact Information ◦ Publications ◦ Awards ◦ Narratives ◦ Photo Additionally, it contains network and connection pages with visualization tools to view a person’s areas of research and how they are connected to others. 8/11/1511

12. Profiles Useful for learning about faculty research interests and areas Can contact faculty if seeking a mentor and see if an MSR project is available Provides opportunity to refer to another faculty member(s) 8/11/1512

13. Training and Support Please visit the CTSI website for more information on these tools, training requirements and how to obtain access. http://ctsi.psu.edu/ For help or to schedule training: REDCap: redcap@hmc.psu.eduredcap@hmc.psu.edu i2b2: i2b2@hmc.psu.edui2b2@hmc.psu.edu Profiles:No training requirement Open Office Hours every Thursday, 3:00-4:00 pm in H4510J for REDCap and i2b2. 8/11/1513

14. Questions… 8/11/1514