1. Sickle Cell, The Sticky Cell: 7th Grade Life Science Module Math and Science Partnership Teacher’s Professional Development Workshop McWane Science Center September 19, 2013 Lauren C. Jackson Undergraduate TU Dee Dee Canionero, M.S. Dr. Chastity Bradford, PhD

2. Module Pre-Requisites This module is designed for students with a background knowledge of: The Central Dogma Chromosomes and Alleles The Circulatory System Tuskegee University's Department of Biology

3. Introduce the Module Using the Five E Model Students should be able to… Recognize Sickle Cell Anemia as an inherited genetic disorder. Understand the Punnett Square. Relate major organs of circulatory system to their functions. Blood Vessels Deliver Oxygen to the Body Tuskegee University's Department of Biology

4. The Five E Model 1.Engage 2.Explain 3.Explore 4.Elaborate 5.Evaluate Tuskegee University's Department of Biology

5. Engage: Pre-Test Video Tuskegee University's Department of Biology

6. Living with Sickle Cell Anemia Tuskegee University's Department of Biology http://youtu.be/qe59ar-GZmg This video—presented by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health—shows how Tiffany, a mother and student, has coped with having sickle cell disease.

7. Explain: PPT Presentation that Highlights Key Concepts Tuskegee University's Department of Biology

8. The Central Dogma DNA  RNA  Protein Tuskegee University's Department of Biology

9. Determining Genotype and Traits: Using The Punnett Square Tuskegee University's Department of Biology

10. DNA  RNA  ? Tuskegee University's Department of Biology Protein: Building Blocks? Amino Acids

11. Tuskegee University's Department of Biology

12. What is the Function of Red Blood Cell ? Tuskegee University's Department of Biology Carry Oxygen Through Body

13. What do Red Blood Cells Travel Through? Tuskegee University's Department of Biology Blood Vessels

14. Circulatory System The overall function of the circulatory system is to transport blood throughout the body. Circulatory System Organs: Heart and Blood Vessels – Arteries – Veins Blood (Hemoglobin) Cells: Red Blood Cells Tuskegee University's Department of Biology

15. Protein Shape Function

16. The Punnett Shuffle To the right (4x), To the left (4x) Now switch (4x), Now move it down a square (2x) To the right (4x), To the left (4x) That’s it (4x), Now that’s your Punnett Square (2x) Tuskegee University's Department of Biology

17. Elaborate: Review Worksheet Tuskegee University's Department of Biology

18. Sickle Cell Anemia: A serious blood disorder, inherited from both parents, in which the body makes sickle-shaped red blood cells instead of normal shaped red blood cells. Tuskegee University's Department of Biology

19. Evaluate: Post Test