Presentation on theme: "Sickle Cell Anemia - basics (? #1) O Sickle cell anemia (or sickle-cell disease) is an inherited disorder of the red blood cells– it causes blood cells."— Presentation transcript:
Sickle Cell Anemia - basics (? #1) O Sickle cell anemia (or sickle-cell disease) is an inherited disorder of the red blood cells– it causes blood cells to collapse and distort into sickle shapes when oxygen is low.
Normal hemoglobin (? #3 a,b) O Hemoglobin is a protein found in red blood cells. O Hemoglobin binds to oxygen and transports oxygen to all the cells in your body.
How is hemoglobin S different from hemoglobin A? (? #3c) What happens after hemoglobin S releases oxygen? (? #3d) O Hemoglobin A (normal) is different from hemoglobin S by only one single component (amino acid) O This small difference in structure causes the hemoglobin S to crystalize when oxygen is released. O This causes the blood cells to collapse and form a sickle-shape.
What consequences to the sickle cells have on people with the disease? (? #5) O Because of their shape, sickle cells cannot easily flow through small blood vessels. O They get trapped and stop the flow of blood- preventing vital organs from getting blood. O Sometimes small blood vessels burst causing internal bleeding and pain. O Sickle cell animation Sickle cell animation
Symptoms of sickle-cell disease (? #4) O Jaundice O Anemia O Pain O Damaged organs and organ failure O Stroke
Sickle cell anemia vs. ‘sickle cell trait’ (? #6) O People with Sickle cell trait SCT) are generally healthy, but carry one allele for the disease (heterozygous) O The alleles are co-dominant O Thus, although not sick themselves, carriers could pass on the trait to children.
Test used to detect SCA/SCT O Change in single amino acid alters the shape and electrical charge on the hemoglobin O Hemoglobin A is slightly MORE negative than Hemoglobin S O This means in a gel, A will travel faster and farther than S.
NPR Radio Article: NCAA and Sickle Cell Trait- Should Athletes Get Tested? NPR: should testing be required? NPR: should testing be required? O Title a page in your journal ‘NCAA and Sickle-Cell Trait’ O List key facts during the first round of listening. O During the second round of listening, list reasons for and against getting tested for sickle-cell trait.