Presentation is loading. Please wait.

Presentation is loading. Please wait.

Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair.

Published byEric Lamb Modified over 8 years ago

Similar presentations

Presentation on theme: "Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair."— Presentation transcript:

1 Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair by Yasuharu Matsumoto, Volker Adams, Claudia Walther, Caroline Kleinecke, Peter Brugger, Axel Linke, Thomas Walther, Friedrich Wilhelm Mohr, and Gerhard Schuler EHJ Volume 30(3):346-355 February 1, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

2 Flow chart of the study. Yasuharu Matsumoto et al. Eur Heart J 2009;30:346-355 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

3 Histological and immunohistological detection of β-galactosidase (β-gal)-positive cells and the expression of CD31 and Krüppel-like factor-2. Yasuharu Matsumoto et al. Eur Heart J 2009;30:346-355 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

4 FACS analysis of CD34pos cells and endothelial progenitor cells in patients with aortic valve stenosis (AS) and controls. Yasuharu Matsumoto et al. Eur Heart J 2009;30:346-355 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

5 Evaluation of the migratory capacity of endothelial progenitor cells from controls and patients with aortic valve stenosis (AS). Yasuharu Matsumoto et al. Eur Heart J 2009;30:346-355 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

6 Quantitative analysis of telomere-repeating factor-2 (TRF-2) expression (A) and caspase-3 activity (B) in endothelial progenitor cells (EPCs) isolated from controls and patients with aortic valve stenosis (AS). Yasuharu Matsumoto et al. Eur Heart J 2009;30:346-355 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

7 Working model to explain the impaired regeneration of the endothelial cell (EC) layer in patients with aortic valve stenosis based on our findings. Yasuharu Matsumoto et al. Eur Heart J 2009;30:346-355 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Download ppt "Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair."

Similar presentations

Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies by Lawrence de Koning,

Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies by Lawrence de Koning,
B-CONVINCED: Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode by Guillaume.

B-CONVINCED: Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode by Guillaume.
The relationship between body mass index, treatment, and mortality in patients with established coronary artery disease: a report from APPROACH by Antigone.

The relationship between body mass index, treatment, and mortality in patients with established coronary artery disease: a report from APPROACH by Antigone.
An optical coherence tomography study of a biodegradable vs. durable polymer-coated limus-eluting stent: a LEADERS trial sub-study by Peter Barlis, Evelyn.

An optical coherence tomography study of a biodegradable vs. durable polymer-coated limus-eluting stent: a LEADERS trial sub-study by Peter Barlis, Evelyn.
Substrate and Trigger Ablation for Reduction of Atrial Fibrillation (STAR AF): a randomized, multicentre, international trial by Atul Verma, Roberto Mantovan,

Substrate and Trigger Ablation for Reduction of Atrial Fibrillation (STAR AF): a randomized, multicentre, international trial by Atul Verma, Roberto Mantovan,
Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation by Jesper Hjortnaes, Jonathan.

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation by Jesper Hjortnaes, Jonathan.
Endurance sport practice as a risk factor for atrial fibrillation and atrial flutter by Lluís Mont, Roberto Elosua, and Josep Brugada Europace Volume 11(1):11-17.

Endurance sport practice as a risk factor for atrial fibrillation and atrial flutter by Lluís Mont, Roberto Elosua, and Josep Brugada Europace Volume 11(1):11-17.
Clopidogrel pre-treatment in stable angina: for all patients >6 h before elective coronary angiography or only for angiographically selected patients a.

Clopidogrel pre-treatment in stable angina: for all patients >6 h before elective coronary angiography or only for angiographically selected patients a.
High spatial resolution myocardial perfusion cardiac magnetic resonance for the detection of coronary artery disease by Sven Plein, Sebastian Kozerke,

High spatial resolution myocardial perfusion cardiac magnetic resonance for the detection of coronary artery disease by Sven Plein, Sebastian Kozerke,
Application of a new algorithm in the differential diagnosis of wide QRS complex tachycardia by András Vereckei, Gábor Duray, Gábor Szénási, Gregory T.

Application of a new algorithm in the differential diagnosis of wide QRS complex tachycardia by András Vereckei, Gábor Duray, Gábor Szénási, Gregory T.
Percutaneous mitral valve repair with the MitraClip system: acute results from a real world setting by Corrado Tamburino, Gian Paolo Ussia, Francesco Maisano,

Percutaneous mitral valve repair with the MitraClip system: acute results from a real world setting by Corrado Tamburino, Gian Paolo Ussia, Francesco Maisano,
Coronary computed tomography angiography with a consistent dose below 1 mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition.

Coronary computed tomography angiography with a consistent dose below 1 mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition.
Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer.

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer.
Paradoxical low flow and/or low gradient severe aortic stenosis despite preserved left ventricular ejection fraction: implications for diagnosis and treatment.

Paradoxical low flow and/or low gradient severe aortic stenosis despite preserved left ventricular ejection fraction: implications for diagnosis and treatment.
Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy by Christian Templin,

Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy by Christian Templin,
Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction by Tashera E. Perry, Minjung Song, Daryl J.

Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction by Tashera E. Perry, Minjung Song, Daryl J.
Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with.

Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with.
The origin of post-injury neointimal cells in the rat balloon injury model by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania.

The origin of post-injury neointimal cells in the rat balloon injury model by Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania.
Platelet thrombin receptor antagonism and atherothrombosis by Dominick J. Angiolillo, Davide Capodanno, and Shinya Goto EHJ Volume 31(1):17-28 January.

Platelet thrombin receptor antagonism and atherothrombosis by Dominick J. Angiolillo, Davide Capodanno, and Shinya Goto EHJ Volume 31(1):17-28 January.
Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:

Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:

Similar presentations

Ads by Google