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Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:

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Presentation on theme: "Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:"— Presentation transcript:

1 Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35 by Marc S. Sabatine, David A. Morrow, James A. de Lemos, Petr Jarolim, and Eugene Braunwald EHJ Volume 30(2):162-169 January 14, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

2 Cardiac troponin I levels (median and interquartile range) measured using the ultrasensitive assay in patients with none (blue circles), mild (green triangles), and moderate-to-severe (red squares) ischaemia at baseline (samples available in 44, 30, and 34 patients, respectively), immediately after stress testing (37, 26, and 27 patients), 2 h after stress testing (20, 15, and 16 patients), and 4 h after stress testing (44, 28, and 36 patients). Marc S. Sabatine et al. Eur Heart J 2009;30:162-169 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

3 Change in cardiac troponin I levels (median and interquartile range) measured using the ultrasensitive assay from baseline to 4 h in patients with none (n = 39, blue circles), mild (n = 27, green triangles), and moderate-to-severe (n = 33, red squares) ischaemia. Marc S. Sabatine et al. Eur Heart J 2009;30:162-169 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

4 Odds ratios and 95% confidence intervals for prediction of inducible myocardial ischaemia. Marc S. Sabatine et al. Eur Heart J 2009;30:162-169 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

5 Proportion with inducible ischaemia among patients categorized by the number of ischaemia predictors (limiting angina, ST depression >0.1 mV, >1.3 pg/mL rise in ultrasensitive cardiac troponin I by 4 h, and post-stress test BNP ≥80 pg/mL). Marc S. Sabatine et al. Eur Heart J 2009;30:162-169 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

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