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Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation by Jesper Hjortnaes, Jonathan.

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Presentation on theme: "Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation by Jesper Hjortnaes, Jonathan."— Presentation transcript:

1 Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation by Jesper Hjortnaes, Jonathan Butcher, Jose-Luiz Figueiredo, Mark Riccio, Rainer H. Kohler, Kenneth M. Kozloff, Ralph Weissleder, and Elena Aikawa EHJ Volume 31(16):1975-1984 August 14, 2010 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org

2 Induction of osteogenesis in carotid arteries and aortic valves of apoE−/− and chronic renal disease apoE−/− mice, detected by intravital fluorescence microscopy. Jesper Hjortnaes et al. Eur Heart J 2010;31:1975-1984 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org

3 Loss of bone mineral density and alterations in microarchitecture in mouse femurs, detected by 3D micro-computed tomography and molecular imaging. Jesper Hjortnaes et al. Eur Heart J 2010;31:1975-1984 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org

4 Inverse correlation of bone tissue mineral density with arterial and aortic valve calcification. Jesper Hjortnaes et al. Eur Heart J 2010;31:1975-1984 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org

5 Induction of inflammatory signal in carotid arteries and aortic valves of apoE−/− and chronic renal disease apoE−/− mice, detected by intravital fluorescence microscopy. Jesper Hjortnaes et al. Eur Heart J 2010;31:1975-1984 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org

6 Correlation of long bone inflammation with osteogenic activity. Jesper Hjortnaes et al. Eur Heart J 2010;31:1975-1984 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org

7 Relationship between bone osteogenic activity and inflammation. Jesper Hjortnaes et al. Eur Heart J 2010;31:1975-1984 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org

8 Schematic presentation of a hypothetical model on the paradoxical relationship between cardiovascular calcification and bone mineral loss, associated with local and systemic inflammation. Jesper Hjortnaes et al. Eur Heart J 2010;31:1975-1984 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org

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