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Liver Tutorial 2. Normal Liver Liver: response to injury.

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Presentation on theme: "Liver Tutorial 2. Normal Liver Liver: response to injury."— Presentation transcript:

1 Liver Tutorial 2

2 Normal Liver

3 Liver: response to injury

4

5 Systemic responses to liver injury

6 Liver function tests

7 Signs and complications of liver disease

8 Bilirubin metabolism and elimination Normal production Binding to albumin Liver uptake Conjugation De-conjugation and excretion

9 Causes of Jaundice

10 Classification of hepatitis

11 Hepatitis A: serology response

12 Hepatitis B: serology response

13 Liver: Hep B

14 Hepatitis B: outcomes

15 Hep B: outcomes

16 Hepatitis C: outcomes

17 Hep C

18 Hep D and B co-infection

19 The hepatocyte in acute and chronic hepatitis

20 Morphological features of viral hepatitis

21 Other causes of hepatitis: Alcohol Diabetes mellitus Chronic active hepatitis (auto-immune) Neonatal hepatitis Other viral disorders -EBV -CMV -Yellow fever -Rubella -Adenovirus -Enterovirus

22 Acute Pancreatitis Metabolic: Alcohol Hyperlipoproteinaemia Hypercalcaemia Drugs (thiazides) Genetic Mechanical: Gallstones Traumatic injury Peri-operative injury Vascular: Shock Atheroembolism PAN Infections: Mumps Coxsackie Mycoplasma

23 Mechanism of acute pancreatitis

24 Causes of Diabetes Mellitus

25 The adipocyte in Diabetes Mellitus *Peroxisome proliferator activated receptor *

26 Complications of Diabetes Mellitus

27 Metabolic derangements In Type I diabetes mellitus


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