1. Neurons and Neurotransmitters

2. Nervous System –Central nervous system (CNS): Brain Spinal cord –Peripheral nervous system (PNS): Sensory neurons Motor neurons (somatic and autonomic)

3. The Nervous System A physical organ system like any other 2 main kinds of cells –Neurons –Glia

4.  Basic units of the nervous system  Receive, integrate, and transmit information  Operate through electrical impulses  Communicate with other neurons through chemical signals  More about neurons and neuronal anatomy later Neurons

5. Glial cells 100 billion neurons 10x more glial cells Glial cells –Support neurons (literally, provide physical support, as well as nutrients) –Cover neurons with myelin –Clean up debris –“Housewives”

6. Three main types of neurons Sensory Neurons Interneurons Motor Neurons

7. Sensory (Afferent) vs. Motor (Efferent) e.g., skin e.g., muscle Gray’s Anatomy 38 1999 sensory (afferent) nerve motor (efferent) nerve Neurons that send signals from the senses, skin, muscles, and internal organs to the CNS Neurons that transmit commands from the CNS to the muscles, glands, and organs

8. Neuron Anatomy and Neural Communication

9. Neurons Axon of another neuron Cell Body Dendrites Axon Myelin Sheath Dendrites of another neuron

10. Neural Anatomy  Dendrite  the bushy, branching extensions of a neuron that receive messages and conduct impulses toward the cell body  Axon  the extension of a neuron, ending in branching terminal fibers, through which messages are sent to other neurons or to muscles or glands

11. Neural Anatomy and communication  Synapse  junction between the axon tip of the sending neuron and the dendrite or cell body of the receiving neuron  tiny gap at this junction is called the synaptic gap or cleft

12. Specific Parts: The Neuron Structure

13. Action Potential When dendrites stimulated, the delicate balance is altered Membrane breaks down Causes release of chemicals from terminal buttons

14. Relay Race Action Potential starts at dendrite –Through cell body –Down Axon –Axon Terminals How does it get to the next cell’s dendrites? Neurons don’t touch –Synapse = millionth inch gap –In synapse = vesicles w/ neurotransmitters »Chemical messengers that transmit info

15. Communication Impulse releases neurotransmitter from vesicles Neurotransmitter enters synaptic gap Neurotransmitter binds to receptors on the receiving neuron

16. Myelin Sheath –Fatty material made by glial cells –Insulates the axon –Allows for rapid movement of electrical impulses along axon –Nodes of Ranvier: gaps in myelin sheath where action potentials are transmitted –Multiple sclerosis is a breakdown of myelin sheath –Speed of neural impulse Ranges from 2 – 200+ mph

17. Neurotransmitters  chemical messengers that traverse the synaptic gaps between neurons  when released by the sending neuron, neurotransmitters travel across the synapse and bind to receptor sites on the receiving neuron, thereby influencing whether it will generate a neural impulse

18. More neurotransmitters Receptor binding movie

19. More Definitions Nucleus – Control Center of the Cell. Synaptic Terminal – Contain neurotransmitters that makes contact with the dendrites of another neuron. Cell Body – surrounds the nucleus, branches off into dendrites, and sends messages to the axon.