1. Fraunhofer MEVIS Institute for Medical Image Computing
Bremen / Lübeck - Germany

2. Contents Overview Evolution and structure Fraunhofer MEVIS
Innovation chain
Perspectives

3. Field of Work Computer assistance for image-based, personalized
diagnosis and therapy

4. Til Mette
stern - April 2005

5. Characteristics Focus on image-based SW solutions for clinicians
Whole chain: early detection, diagnosis, therapy, monitoring
Epidemiologically important diseases
Patient-individual solutions
Transdisciplinary approach
Clinical network
150+ clinical and scientific partners worldwide
Complete innovation chain
basic research research prototype product
Medicine
Industry
Science

6. Image Modalities Radiography (MX, AX) Computed tomography (CT, CTA)
Modality
2-D
3-D
Dynamic [t]
Radiography (MX, AX)
Computed tomography (CT, CTA)
Magnetic resonance imaging (MRI, MRA)
Ultrasound (US) … …
MR Spectroscopy, Microscopy/Histology, …

7. Why computer support?

8. Why computer support?

9. Dimensions of Competence
Methods
MeVisLab
Validation
Navigation
Risk analysis
Visualization
Quantification
Segmentation
Registration
Modeling/ Simulation
Imaging/ Modality
Organs
Liver
Lung
Breast
Brain
Heart/Vessels
Bones/Joints
Diseases (Tumor, Inflammation, Degeneration, etc.)
Diagnosis
Clinical Workflow
Early Detection Diagnostic Planning Procedure Monitoring
Therapy

10. Fields of Activity Algorithms, Software Applications & Computing
Visualization & Human Computer Interaction
Workflow, Clinical Usability, …
Intra-operative/-interventional Support
Liver, Lung, Breast, …
Mathematical Modelling & Numerical Simulation
Foundation Professorship at Jacobs University
MR Imaging & Physics
Foundation Professorship at University Bremen
Image Registration
Project Group at University Lübeck

11. 2. Evolution and structure

12. MeVis Family Tree
University Non-profit Commercial :
2009
2007
2005
2003
2001
1999
1997
1995
1993
emerged from daughter of

13. Structure since 01/2009
Non-profit Commercial (75 employees) (230 employees)
50%
Institute for Medical Image Computing
Bremen
Bremen
41%
Bremen
50%
51%
100%
100% NL
EFRE
50%
Project Group Image Registration
Lübeck (since 04/2010)
S-H
Bremen USA Japan
50%
EFRE

14. 3. Fraunhofer MEVIS

15. Fraunhofer Society Fraunhofer Groups
Information & Communication Technology
Life Sciences
Microelectronics
Surface Technology & Photonics
Production
Materials & Components
Defense & Security
59 institutes in GER
employees
about 1.6 billion EUR research budget
2/3 from industry and public agencies

16. Fraunhofer Society 59 Institutes in GER Institutes
Karlsruhe
Darmstadt
Würzburg
Jena
Stuttgart
Duisburg
Oberhausen
Nuthetal
Dortmund
München
Saarbrücken
St. Ingbert
Magdeburg
Halle
Dresden
Leipzig
Ilmenau
Cottbus
Braunschweig
Berlin
Potsdam
Teltow
Aachen
Schmallenberg
Sankt Augustin
Erlangen
Nürnberg
Freising
Holzkirchen
Pfinztal
Freiburg
Efringen-Kirchen
Rostock
Itzehoe
Hannover
Bremen
Euskirchen
Chemnitz
Wertheim
Kaiserslautern
Paderborn
Schkopau
Lübeck
59 Institutes in GER
Institutes
Branches, Working Groups, Application Centers
Bremerhaven

17. Extended Board KG plus Dr. Kuhnigk, Dr. Zidowitz, Person of Trust
Organization Chart
Institute Director
Prof. Peitgen
Extended Board KG plus Dr. Kuhnigk, Dr. Zidowitz, Person of Trust
Management Board (KG)
Prof. Peitgen, Prof. Hahn, Prof. Preußer, Prof. Günther, Prof. Fischer, Dr. Kraß, Dr. Lang, Dr. Prause, T. Forstmann
Administration
T. Forstmann
Advisory Board
Persons of Trust

18. Organization of Work Team-oriented Open-minded Self-organized Flexible
Adaptive

19. Advisory Board of Fraunhofer MEVIS
Prof. Dr.-Ing. E.R. Reinhardt
Chair:
Dr. R. Jansen
Dr. U. Niebling
Research Funding:
Dr. C.J.G. Evertsz
Dr. B. Gewiese
Prof. Dr. H. Maier
W. Märzendörfer
Industry:

20. Advisory Board of Fraunhofer MEVIS
Prof. Dr. J. Hennig
Prof. Dr. W.A. Kalender
Prof. Dr. R. Kikinis
Prof. Dr. H.-P. Schlemmer
Prof. Dr. G. Székely
Science:
Prof. Dr. H.-P. Bruch
Prof. Dr. K.J. Klose
Prof. Dr. M. Reiser
Prof. Dr. U. Sure
Medicine/ Clinic:
Prof. Dr. J. Falta
Dr. A. Ziegler-Jöns
Uni Bremen: Jacobs University:

21. Management Board
Prof. Dr. Heinz-Otto Peitgen Prof. Dr. Horst K. Hahn Dipl.-Betrw. Thomas Forstmann
Institute Director Deputy Institute Director Head of Administration
Uni Bremen Adj. Jacobs Uni
Uni Boca Raton Research
Prof. Dr. Matthias Günther Prof. Dr. Tobias Preußer Prof. Dr. Bernd Fischer
Head of MR Imaging Head of Modeling & Simulation Head of PG Image Registration
Uni Bremen Jacobs Uni Head of MIC Institute
Uni Lübeck
Dr. Stefan Kraß Dr. Markus Lang Dr. Guido Prause
Clinical cooperations Scientific personell Publicly funded projects
Industry projects Industry projects PR / Advisory Board
Publicly funded projects IPR / contracts Deputy Head of Administration

22. Extended Management Board
Persons of Trust
Melanie Bohn
Bianca Lassen
Lars Bornemann
Dr. Benjamin Geisler
Dr. Jan-Martin Kuhnigk
IT, Software Development
Dr. Stephan Zidowitz
Quality Management 22

23. Finance (MEVIS Bremen)
TEUR
Inv.
BHH HB HB HB HB
EFRE HB HB

24. Personnel (MEVIS Bremen)
MMS: ≈ 230
CeVis: ≈ 10

25. Certification Certificate for quality assurance (since 2005) Scope:
Introduction and application of a quality management system in compliance with
EN ISO 9001 /
EN ISO / (medical devices)
Scope:
Research and development for image-based medical diagnosis and therapy
Development of software

26. Awards
RSNA 95/97/00-02:
Oct 1996:
Dec 1999:
Mar 2005:
Apr 2005:
Mai 2005:
Feb 2006:
Sep 2006:
Sep 2007:
Nov 2007:
Scientific Exhibit Award with Certificate of Merit (Radiological Society of North America)
Bundesverdienstkreuz erster Klasse für Prof. Peitgen (Bundespräsident Roman Herzog)
Karl Heinz Beckurts-Preis für Forschung und Innovation (Karl Heinz Beckurts-Stiftung)
Magna Cum Laude Award for Most Innovative Contribution (European Congress of Radiology)
Werner Körte Medaille in Gold (Deutsche Gesellschaft für Chirurgie)
Bremer Unternehmerpreis für Wissenstransfer (ASU, BJU)
Induction of Prof. Peitgen into Hall of Fame at FAU
Deutscher Gründerpreis 2006 (Sparkasse, McKinsey, stern, ZDF)
Eurographics 2007 Medical Prize
Bernd-Artin Wessels-Preis 2007

27. German Founders Prize 2006
Sep 12, 2006: ZDF studio in Berlin

28. 4. Innovation chain

29. Innovation Chain Clinical Network >150 Europe, Asia, USA Siemens
Hologic
Clinical Network
>150
OUTPUT
Invivo
INPUT
Philips
Toshiba

30. R&D Structure at MeVis
Product :
Algorithmic
Development
Customization
Clinical
Testing
Network
Integration
Clinical
Evaluation
Prototype
Algorithm
Idea
Technical
Testing
MeVisLab: SW Platform for R&D, Prototyping, Evaluation & Integration

31. Publicly Funded Projects
BMBF:
FUSION (6,75 WiMi + 1 MTRA)
kostenn. Verlängerung
DOT-MOBI mit DKFZ, ITWM, MMS und Siemens (6 WiMi)
Kompetenznetz ASTHMA-MRI mit 6 klin. Partnern (1 WiMi)
LungSys mit 12 Partnern (1 WiMi)
PMRIT: Physiological MRI during Throbolysis (1,5 WiMi)
Virtuelle Leber: Mathematische Modellierung der Leber mit div. Partnern (3,7 WiMi) bis 03/2015
Spitzencluster: Medical Valley mit Siemens, IIS und div. Partnern (1,5 WiMi) bis 09/2013
MoBiTech3: MALDI-AMK mit Bruker, ZeTeM, CUCA u.a. (1 WiMi) bis 12/2013
DFG:
RFITT mit UKBF (0,5 WiMi)
Klinische FG Essen: LLS/A2 - OP (1 WiMi)
Klinische FG Essen: LLS/B2 - Histologie (1 WiMi)
Lunge/COPD mit DKFZ (1 HiWi)
Lungenchirurgieplanung (1 WiMi + 0,5 MTRA + 1 HiWi)
Neurochirurgie-Risikoanalyse mit Marburg (1 WiMi + 1 HiWi)
EU:
HAMAM mit EIBIR-Partnern und Industrie (2 WiMi)
ESFRI: Euro-BioImaging mit EIBIR-Partnern (0,1 WiMi) bis 07/2013
ICT-VPH: FUSIMO mit Uni Dundee, TU Delft, SINTEF u.a. (3 WiMi) bis 12/2013
Andere:
R.-Bosch-Stiftung: OP-Projektion mit Prof. Lamade, RBKH Stuttgart (0,4 WiMi)
WFB: 3D-MALDI mit ZeTeM und Bruker (0,2 WiMi)
DHZB: Cardio-MRI in Congenital Heart Disease (0,8 WiMi) J F M A S O N D
2009
2010
2011
2012

32. Cooperations with Industry
Fraunhofer MEVIS
MMS AG
Siemens AG
Stryker
several others in publicly funded projects
OEM partners of MMS AG
Hologic
Philips/ Invivo
Toshiba

33. Three Success Stories Market share >50% Breast-MRI
- Neoangiogenesis and Biopsy
Breast Cancer Screening
- Digital Mammography
>50%
Surgery Planning
- Internet-based Service
>90%

34. 1. Breast-MRI: Tumor Dynamic & Biopsy34

35. 2. Mammography Workstation
Softcopy reading in digital mammography
First prototype: master thesis
EU Projects:
- SCREEN
- SCREEN-TRIAL
Mammography
Screening
Bremen
Today: World market leader with over systems
Siemens: MammoReportPlus Reporting Station
Hologic: LORAD Selenia Reporting Station 35

36. 3. Liver Surgery Planning

37. Distant Service via Internet
USA
Japan
Europe
Korea
Egypt
Australia
China
certified
Taiwan
Singapore 37

38. Status since 2003: > 5.000 plannings at MeVis
150+ Users Worldwide
Asia, USA, Europe
Germany
Kyoto University Hospital, Japan
Yokohama City University Medical School, Japan
Nagoya University Hospital, Japan
University Hospital Kanazawa, Japan
Kaohsiung University Hospital, Kaohsiung, Taiwan
Lahey Clinic, Burlington, MA, USA
Massachusetts General Hospital, Boston, MA, USA
University of California at San Francisco, USA
Columbia University, USA
University of Michigan, USA
Universtity of California at Los Angeles, USA
Washington University St. Louis, USA
Strong Memorial Hospital, Rochester, NY, USA
NIH Clinic, Bethesda, MD, USA
State University Hospital, Groningen, Netherlands
Lund University Hospital, Sweden
Verona University Hospital, Verona, Italy
Naples University Hospital, Naples, Italy
Univerity Hospital Sapienza Rome, Italy
Gleneagles Hospital, Singapore
Charité Berlin, Campus Benjamin Franklin
Charité Berlin, Campus Buch
Charité Berlin, Campus Virchow
Allgemeines Krankenhaus Celle
Universitätsklinikum Essen
Johann Wolfgang Goethe Universität Frankfurt
Universitätsklinik Freiburg
Medizinische Hochschule Hannover
Klinikum Hof
Universitätsklinik Köln
Klinikum Krefeld
Klinikum Schleswig-Holstein, Campus Lübeck
Universitätsklinikum Mainz
Klinikum der Philipps-Universität Marburg
Klinikum rechts der Isar München
Universitätsklinik Tübingen
Status since 2003: > plannings at MeVis
≈ LDLTs ≈ Tumor resections
≈ Pancreas, kidney, spleen, …

39. 5. Perspectives

40. Perspectives New fields Personnel MR Scanner MeVis Campus
Modeling and simulation
MR imaging
Image registration
Personnel
82+ employees until 2013 at Fraunhofer MEVIS
MR Scanner
MeVis Campus

41. Modeling and Simulation
Jacobs University Bremen
Foundation professorship by Conrad and Lotti Naber
Modeling of bio-physical processes
Numerical simulation
Examples
RF-Ablation of liver tumors
Numerical flow simulation
High focused ultrasound
Prof. Dr. Tobias Preußer

42. MR Imaging & Physics University Bremen – FB Physics
Foundation professorship by Stiftung Bremer Wertpapierbörse
Optimization of imaging
Development of new sequences and imaging protocols
Examples
Arterial Spin-Label Imaging
Diffusion Tensor Imaging
Prof. Dr. Matthias Günther

43. Image Registration
Fraunhofer MEVIS – Project Group Lübeck University Lübeck – Institute of Mathematics
Basic funding by State Schleswig-Holstein
Anatomically correct mapping and fusion of medical image data
Examples
Registration of pre-, intra- und postoperative images
Multimodal image registration
Prof. Dr. Bernd Fischer

44. www.mevis.fraunhofer.de EUROPEAN UNION: Investing in your future
European Regional Development Fund