1. Medical Innovation Center Team University of Michigan Executive Director Dr. James Geiger Pediatric Surgery Associate Director Professor Albert Shih Mechanical Engineering Managing Director Brenda Jones, MBA Assistant Director Education Jennifer Stovall Prototype Specialist Toby Donajkowski Associate Director Dr. Jeff Myers Anatomic Pathology

2. Basic Format for Fellowship Duration – 1 Year, July-June (Med School Schedule) Process of selecting fellows - Application, essays, letters of recommendation, individual and group interviews, survival team exercise How are projects determined? Domain (destination program) direct clinical observation in specific domain, wisdom of crowds, pair-wise comparison, Technical Advisory Group feedback Advisors, mentors? 2 per team plus professional team coach What are major deliverables for the fellows? (1) Greater understanding of medical innovation development and challenges of multidisciplinary groups (2) Commercializable product idea University of Michigan Medical Innovation Center July Creation Solution-Business Knowledge Foundation Opportunity Exploration Core Support Domain SeptemberDecemberMarchJune

3. Unique Features of Program Anti-disciplinary - Medical, Business, Engineering, other Major health system and top ranking schools all on one campus Team volunteer work-campus ambassadors of innovation “Blank slate” to develop ideas from unmet needs within domain University of Michigan Medical Innovation Center

4. Challenges Sustainability (funding) Recruiting fully engaged faculty Program identity balance – Education program vs Inventor assistance program Changing the culture A “start-up” in a big bureaucracy Evolution of Biomedical Device Industry University of Michigan Medical Innovation Center

5. Catheter Securement-Novel IV Catheter University of Michigan Medical Innovation Center Starting Sub-Domains Domain Opportunity Discovery Solution Creation Opportunity Profiles Clearly Defined Market Needs With Potential Solution Concepts Offering Development Solution Concepts Design Concepts Ready for Prototyping and/or Market Experimentation Provisional filing Angel investment 510K in process