1. 1 YORK UNIVERSITY Department of Biology Faculty of Science and Engineering Course outline Immunobiology (SC/BIOL 3120 3.0) W2011 Prerequisites: SC/BIOL2020 4.0; SC/BIOL2021 4.0

2. 2 Welcome to BIOL3120! SC/BIOL3120 3.0 Prerequisites: SC/BIOL2020 4.0; SC/BIOL2021 4.0 Objectives: The course is designed to provide students with a sound, comprehensive understanding of the immune system, including the Biology and Chemistry of immune responses. Topics will include anatomy/development of the immune system, structure and function of antibodies, T cell receptors, antigen receptor diversity, cellular interactions, and immunological responses in disease such as Cancer.

3. 3 Instructor: Dr. Michael Scheid Rm. 236 Farqharson Building Website: www.yorku.ca/mscheid E-mail: through WebCT only please Course timetable: Tuesdays 11:30 am – 1:00 pm SLH F Thursdays 11:30 am – 1:00pm CSE A Office hours: Friday 9:30-11:00 am

4. 4 TEXTBOOK: The Immune System, Third Edition. Garland Science Author: Peter Parham Required Available at the York University Bookstore Two copies are available at the Stacie Library reserve desk

5. 5 COURSE Web Site: WebCT A York WebCT account is required to access online course material. Information about WebCT at York can be found at: www.yorku.ca/fsc/webct/student/quickstart.htm WebCT is the online resource for this course. It will be used for private mail to the instructor or to the TA, for accessing your grades, and for other course-related resources. Midterm examination grades will be posted when they become available. Please do not email the instructor nor the TA asking when grades will be posted. The Midterms will not be returned but will be available for viewing during office hours.

6. 6 STUDENT EVALUATION: There will be TWO Midterm exams, each worth 25% of your grade: Midterm 1 – February 3 Midterm 2 – March 10 Final Exam : 50% [Date to be announced by registrar. Cumulative] [If an evaluation is not completed, a “0%” grade will be earned for that evaluation] Please note: 1.Exam questions will be derived from lectures, lecture material and the text book. 2.Midterm exams will be multiple choice and true/false. 3.Final exam will be a combination of multiple choice, short answer, and long answer questions.

7. 7 Please note : There will be NO MAKE-UP of the midterm exams. For medical issues please have your physician fill out the Attending Physician Statement. This form is available from the Registrars website.

8. 8 Academic Integrity: Senate Policy on Academic Dishonesty Students are expected to be familiar with and follow York University’s Policies regarding academic integrity. Please consult the website below for more details: http://www.yorku.ca/academicintegrity/students.htm

9. 9 ACADEMIC MISCONDUCT WILL NOT BE TOLERATED. Cheating is the attempt to gain an improper advantage in an academic evaluation. Forms of cheating include: – Obtaining a copy of an examination before it is officially available or learning an examination question before it is officially available; – Copying another person’s answer to an examination question; – Consulting an unauthorized source during an examination; – Obtaining assistance by means of documentary, electronic or other aids which are not approved by the instructor; – Changing a score or a record of an examination result; – Submitting the work one has done for one class or project to a second class, or as a second project, without the prior informed consent of the relevant instructors; – Submitting work prepared in collaboration with another or other member(s) of a class, when collaborative work on a project has not been authorized by the instructor; – Submitting work prepared in whole or in part by another person and representing that work as one’s own; – Offering for sale essays or other assignments, in whole or in part, with the expectation that these works will be submitted by a student for appraisal; – Preparing work in whole or in part, with the expectation that this work will be submitted by a student for appraisal.

10. 10 For Thursday please read: Chapter 1 Elements of the Immune System Chapter 2 Innate Immunity

11. 11 Why do we study Immunology?

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13. 13 From the following article: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Jean-Pierre Hugot et al. Nature 411, 599-603(31 May 2001)

14. 14 From the following article: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Jean-Pierre Hugot et al., Nature 411, 599-603(31 May 2001)

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16. 16 From the following article: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Yasunori Ogura, et al., Nature 411, 603-606(31 May 2001)

17. 17 From the following article: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Yasunori Ogura, et al., Nature 411, 603-606(31 May 2001)

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