1. BIO305 Developmental Biology Instructor: Dave Champlin

2. Class meets: Tuesdays and Thursdays, 8:45AM -10:00AM Prerequisite: BIO107 Attendance: Attendance is required. If you miss more than about six classes you should let me know why. Required Text: Principles of Development, 4 rd Edition, 2010. Lewis Wolpert, et al.

3. Instructor: Dr. David Champlin Office: 305B Science Building, Portland Email: champlin@maine.edu Office Phone: 228-8349champlin@maine.edu Office Hours: My office hours will be Tuesdays and Wednesdays, 12:00 - 2:00 PM, but you can make an appointment to meet with me at just about any time. Here is a link that can help you with that: http://web1.uct.usm.maine.edu/~champlin/Advising/Calendar W.htm http://web1.uct.usm.maine.edu/~champlin/Advising/Calendar W.htm

4. Web Resources: A copy of this syllabus is available at: http://media.usm.maine.edu/~champlin/courseW.htm At this site are copies of the exams from the previous time this course was taught. My goal will be to post the PowerPoint presentations I use in lecture at this site also as well as a recording of the lecture for one week.

5. The maximum number of points for the course is 520 as follows: Each is described in more detail on our course web site: http://media.usm.maine.edu/~champlin/courseW.htm http://media.usm.maine.edu/~champlin/courseW.htm review paper worth 100 points two short writing assignments each worth 20 points two exams each worth 100 points cumulative final worth 100 points five quizzes each worth 20 points five in-class assignments each worth 20 points No make-ups for missed quizzes or in-class assignments, but you can drop the lowest two scores of the ten total quizzes / assignments. Each quiz will be announced at least a week ahead of time, but the in-class assignments won’t be announced ahead of time.

6. Day DateReadingTopic T 9/3 pp.216-231 (Ch. 6) C. elegans, model systems, and molecular genetics Watch three Audio/Video handouts: 1A), 1B), and 1C Th9/5Ch. 1An introduction to developmental biology T9/10 QUIZ 1 (covers A/V Handouts 1A, 1B, and 1C) More introduction Watch two Audio/Video handouts: Review of transcription regulation, Parts 1 and 2 Th9/12Ch. 3Vertebrate life cycles T9/17 QUIZ 2(covers A/V Handouts 2A and 2B) Vertebrate axes and germ layers Th9/19 CH. 4Vertebrate axial patterning T9/24More vertebrate body plan Th9/26Ch. 5Early patterning of vertebrate nervous systems T10/1EXAM 1Chapters 1, 3, 4, and pp216-231 Th10/3 Ch. 2Molecular development of Drosophila T10/8More molecular development of Drosophila Th10/10Ch. 7Plant development On Thursday, 10/10, Please bring a copy of the primary research article you have selected (or more than one if you haven’t decided) plus your notes on the article.

7. What is developmental biology?

8. Lewis Wolpert = author of our book

9. What is developmental biology? Lewis Wolpert = author of our book "What is the one thing everyone should learn about science?" Wolpert responded: I would teach the world that science is the best way to understand the world, and that for any set of observations, there is only one correct explanation. Also, science is value-free, as it explains the world as it is.

10. What is developmental biology?

11. BIO407 Environmental Modulation of Developmental Mechanisms Taught every other spring. It was taught last spring. Textbook: Scott Gilbert. 2010. Ecological Developmental Biology: Integrating Epigenetics, Medicine, and Evolution

12. What is developmental biology?

13. Maine Medical Center Research Institute in Scarborough Research internships Summer fellowship program

14. What is developmental biology?

25. You have made your way from worm to man, and much within you is still worm. Friedrich Nietzsche, 1883, from Also Sprach Zarathustra Caenorhabditis elegans C. elegans

27. Caenorhabditis elegans = C. elegans nematode

31. The 2002 Nobel Prize in Medicine was awarded to these scientists for the use of C. elegans to understand programmed cell death (PCD).

32. A fertilized nematode egg and early embryos as viewed with Nomarski optics = Differential Interference Contrast (DIC).

33. As each C. elegans worm grows from the fertilized egg, it has an invariant cell lineage.