1. IMPORTANT OPHTHALMIC TUMOURS MICHAEL E GIBLIN FRANZCO ASIA PACIFIC SOCIETY OF OCULAR ONCOLOGY AND PATHOLOGY

2. Uveal melanoma

3. Iris melanoma Large Diffuse Rapid growth Hyphaema Refractory glaucoma Subjacent ciliary body involvement

4. Symptoms Thickness > 2mm Orange pigment (lipofuscin) Growth Subretinal fluid Peripapillary location Choroidal naevus versus melanoma

5. MM treatment options Observation Transpupillary laser thermotherapy (TTT) Posterior pole Thickness < 3.5mm

7. Melanoma treatment options Observation TTT Local resection Base < 10mm Anterior to equator

8. MM treatment options Observation TTT Local resection Radioactive plaque therapy Base <15(18)mm Thickness < 8mm

9. Ruthenium 106 Iodine 125

10. MM treatment options Observation TTT Local resection Radioactive plaque therapy Proton beam/helium ion irradiation Stereotactic R/T; LINAC/gamma knife

11. MM treatment options Observation TTT Local resection Radioactive plaque therapy Proton beam/helium ion irradiation Sterertactic radiotherapy Enucleation Base > 18mm

12. BAP1 BAP1 = BRCA Associated Protein 1 Recessive cancer suppression gene Located on 3p21.1 Associated with monosomy 3 Inactivating mutation leads to liver metastasis

13. Circumscribed choroidal haemangioma

14. High internal reflectivity

15. Metastatic tumours May be multifocal Characteristically posterior to equator Usually amelanotic Leopard-skin RPE spotting Sub-retinal fluid if active Treat if sight affected Lung ca. Choroidal metastasis may precede detection of primary

17. Retinoblastoma

18. Aim for earlier detection Chemotherapy mainstay of treatment for hereditary retinoblastoma Incresing role for intraarterial chemotherapy