1. Vaccine European New Integrated Collaboration Effort V.E.N.I.C.E Stefania Salmaso Italian National Centre of Epidemiology, Surveillance and Health Promotion Istituto Superiore di Sanità Rome-Italy DGSANCO project

2. Vaccination in EU Total population of approx 459 millions in 25 countries Total population of approx 459 millions in 25 countries Approx 75 millions up to 14 years of age Approx 75 millions up to 14 years of age Approx 75 millions aged more than 64 years Approx 75 millions aged more than 64 years Approx 4.7 millions yearly EU birth cohort Approx 4.7 millions yearly EU birth cohort

3. Rationale Currently many vertical projects addressing single diseases or infections, including some preventable by vaccination (e.g. Euvac-net, IBIS, EISS) Currently many vertical projects addressing single diseases or infections, including some preventable by vaccination (e.g. Euvac-net, IBIS, EISS) No project in the Public Health field is addressing vaccination with an horizontal approach within a EU perspective No project in the Public Health field is addressing vaccination with an horizontal approach within a EU perspective Similarly at EU level there are many other activities on vaccine evaluation (e.g. EMEA) that are not immediately available on the Public Health area. Similarly at EU level there are many other activities on vaccine evaluation (e.g. EMEA) that are not immediately available on the Public Health area. Take advantage of the already made experience and available data, obtained in other concurrent networks and research projects (e.g. DG Research funded Polymod) Take advantage of the already made experience and available data, obtained in other concurrent networks and research projects (e.g. DG Research funded Polymod) Use of information technology developed for IRIDE project. Use of information technology developed for IRIDE project.

4. VACCINE E U R O P E A N E F F O R T I N T E G R A T E D COLLABORATION

5. Specific Objectives 1. To create an EU vaccination network able to collect and collate information on vaccination programs in each MS. 2. To create a resource able to provide advice and support to single member states by integrating available tools and knowledge on various vaccine-related issues. 3. To create a network able to provide support in the development of preparedness strategies including immunisation programs. 4. To define common indicators for monitoring, in a comparable way, the immunisation programs across MSs and as well their constituent regions. 5. To encourage a rational approach to vaccination policy decision-making processes by providing standardized tools. 6. To provide MSs with the necessary information regarding safe vaccination and support capacity building in areas dealing with contraindication and the management of Adverse Events following vaccination.

6. Most relevant topics the indicators the indicators priority setting priority setting AE surveillance and management AE surveillance and management

7. Working Packages WP 1: Coordination WP 1: Coordination (WP Leader: Stefania Salmaso) WP 2: Dissemination of results WP 2: Dissemination of results (WP Leader: Stefania Salmaso) WP 3: Indicators of immunisation programs WP 3: Indicators of immunisation programs (WP Leader: Darina OFlanagan) WP 4: Priority setting and decision-making processes WP 4: Priority setting and decision-making processes (WP Leader: Daniel Levy Bruhl) WP 5: Capacity building in monitoring, prevention and WP 5: Capacity building in monitoring, prevention and management of post vaccination AE (WP Leader: Antonio Ferro)

8. Development of tools and contents web-site web-site repository of documents of common interest repository of documents of common interest tool for confidential exchange of message tool for confidential exchange of message products related information for new vaccines products related information for new vaccines area for collecting country specific data area for collecting country specific data

9. Venice Public Web Portal Web portal Menu http://venice.cineca.org

10. Project advancement (1) Two Annual Workshops Two Annual Workshops Identification of National Gatekeepers and Contact Points Identification of National Gatekeepers and Contact Points Website implemented Website implemented Five surveys among the member states Each survey preceded by a pilot undertaken by the Work Packages countries, and by other randomly selected countries. Five surveys among the member states Each survey preceded by a pilot undertaken by the Work Packages countries, and by other randomly selected countries.

11. Project advancement (2) The first survey Immunization Programs in Europe. Results disseminated on the ECDC biweekly newsletter. The first survey Immunization Programs in Europe. Results disseminated on the ECDC biweekly newsletter. Two surveys, by WP4, on newly released vaccines, against Rotavirus and Human Papillomavirus. Two surveys, by WP4, on newly released vaccines, against Rotavirus and Human Papillomavirus. Survey on Vaccine Coverage carried out by WP3. Survey on Vaccine Coverage carried out by WP3. Survey on Adverse Events Following Immunization, designed and launched by WP5, has gone the pilot phase. Survey on Adverse Events Following Immunization, designed and launched by WP5, has gone the pilot phase.

12. For better immunisation coverage, measure coverage better Papania M, Rodewald L. Lancet Editorial 2006 367 965-6Papania M, Rodewald L. Lancet Editorial 2006 367 965-6Format description schedules description schedules Methods of measuring coverageMethods of measuring coverage Computerised Immunisation registriesComputerised Immunisation registries Discussion US standards on CIRDiscussion US standards on CIR

13. FROM THE SURVEY ON IMMUNIZATION PROGRAMS: Third dose of Diphtheria, Tetanus and Pertussis administered at 4,5,6, and 12 months of age.

14. FROM THE SURVEY ON IMMUNIZATION PROGRAMS Total Number of doses of Diphtheria and Tetanus by age 18 years

15. Lack of quality indicators for immunisation programme Late start rates: % of infants who dont have DTaP IPV Hib 1, MenC 1 by 3 months of age Late start rates: % of infants who dont have DTaP IPV Hib 1, MenC 1 by 3 months of age Drop –off rates: % with DPT1 at 6 months -% with DTaP3 at 12 months Drop –off rates: % with DPT1 at 6 months -% with DTaP3 at 12 months Up-to-date: fully vaccinated for age at benchmark ages of 12 months, 24 months Up-to-date: fully vaccinated for age at benchmark ages of 12 months, 24 months

16. National vs subnational Immunization Programs Subnational administrative areas in 17/27 countries Subnational administrative areas in 17/27 countries In 8 countries (BE,FR,GE, ES,IR,IT,UK,SW) In 8 countries (BE,FR,GE, ES,IR,IT,UK,SW) differences with the national IP in terms of Type of disease targeted Type of disease targeted Age group Age group Purchase Purchase

17. Public Health setting vs private sector In the majority of the countries vaccinations are administered within national health services In the majority of the countries vaccinations are administered within national health services In 6 countries mainly within the private sector In 6 countries mainly within the private sector

18. Establish channels has always been a success of VENICE

19. Thanks http://venice.cineca.org