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Published byJemimah Warner Modified over 9 years ago
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Wake-up 1.A woman carrying hemophilia marries a man who is a hemophiliac. What percentage of their children will have hemophilia? 1.Cross a man heterozygous B with a woman who is a purebred for A. What blood types will their children have?
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Human Genetic Disorders and Pedigrees Christopherson
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Human Genetics: Karyotypes 46 TOTAL 23 homologous pairs 46 TOTAL 23 homologous pairs
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Sex Chromosomes 2 sex chromosomes Typical Female = XX Typical Male = XY
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Autosomes Autosomes: Any chromosome that’s not a sex chromosome 44 Autosomes 22 pairs of Autosomes
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Recessive Disorder Caused by 2 recessive alleles
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Albinism Defect of melanin production that results in little or no color in the skin, hair, and eyes
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Albinism
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How does it happen? Affected Genotype: aa
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Cystic Fibrosis Disease that causes the body to produce unusually thick, sticky mucus that: Clogs the lungs and leads to lung infections Obstructs the pancreas Stops natural enzymes from helping the body break down and absorb food
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How does it happen? Affected Genotype: cc
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Sickle Cell Anemia Caused by an abnormal hemoglobin shape which causes the red blood cells to have a crescent shape. Red blood cells carry oxygen.
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How does it happen? Affected Genotype: ss
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Dominant Disorder Caused by a dominant allele Affected individuals are homozygous dominant or heterozygous
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Huntington’s Disease Causes the break down of brain cells, (neurons) in certain areas of the brain. Causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance.
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How does it happen? Affected Genotype: HH or Hh
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Sex-Linked Disorder Linked to sex chromosomes Recessive Disorders – caused by recessive alleles
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Color Blindness Inability to see colors in the normal way
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How does it happen? Affected Genotypes: X b X b X b Y
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Hemophilia Inability of the blood to clot properly
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How does it happen? Affected Genotypes: X h X h X h Y
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Wake-up 1.What are the genotypes for individuals affected with the following disorders: a.Cystic Fibrosis b.Colorblindness c.Huntington’s disease 2.A parent has a genotype Bb. What alleles can this parent give their children?
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What is a Pedigree??? Diagram showing a family tree and patterns of inheritance.
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Types of Pedigrees: Recessive Affected Genotypes: bb Unaffected Genotypes: BB or Bb HINT: Recessive Disorders skip generations
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Is the Pedigree below showing Recessive Inheritance?
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Recessive Inheritance?
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Types of Pedigrees: Sex-linked Affected Genotypes: X b X b or X b Y Unaffected Genotypes: X B X B or X B X b and X B Y HINT: Mainly males are affected
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Is the Pedigree below showing Sex-Linked Inheritance?
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Sex-linked Inheritance?
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Types of Pedigrees: Dominant Affected Genotypes: BB or Bb Unaffected Genotypes: bb
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Is the Pedigree below showing Dominant Inheritance?
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Dominant Inheritance?
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How many generations? What is genotype of Individual I- 1? What type of Inheritance?
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How many generations? What is genotype of Individual I- 1? What type of Inheritance?
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