1. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 1  Dr. George Goodheart D.C.

2. ICAK Meeting Antwerp September 2008

3. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 3 Patients with diffuse symptoms Vegetative Symptoms:  Tiredness, fatigue  Sweat at night  Shivers  Attacks of fever  Feeling sick  Reduced and poor endurance  Intolerance of alcohol and food

4. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 4 Patients with diffuse symptoms Cardial Symptoms  Palpitations  Mayo- or Pericarditis Intestinal Symptoms  Nausea, gastralgia, burp  Flatulence  Diarrhoe

5. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 5 Patients with diffuse symptoms Musculo-skeletal Symptoms  Arthralgia of changing localisation  Myalgia  Feeling of stiffness in the muscles  Tendinitis with or without swelling, especially Achilles tendon, Epicondylitis, plantar fascitis  Recurrent swelling of fingers, toes and hands  Pain of the sterno-chondral junctions of the ribs  Pain of TMJ

6. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 6 Patients with diffuse symptoms Neurological Symptoms (central)  Disturbed vision ( blurry, wash out, aching eyeballs, aching eyemovements, sensitivity to light )  „burning tounge“  Tinnitus, vertigo  Headache, unilateral and diffuse without relief by analgetics  Loss of concentration, loss of memory, reduced perception  Disturbed sleep  Depression, irritability, anxiety, fluctuation of mood

7. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 7 Patients with diffuse symptoms Neurological Symptoms (peripheral)  Paraesthesia of limbs  Disturbed superficial sensation, hyperpathia  Backpain, sciatica  Sensitivity of scalp ( „aching hairs“ when combing )  Muscular twitching  Sudden weakness in the legs

8. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 8 Patients with diffuse symptoms Urogenital Symptoms:  Burning aches in the bladder, pollakisuria  Pressure sensation in the bladder  Incontinency, disturbance of micturition  Loss of libido  Impaired potency  Recurring aches of testicles, ovaries, vagina

9. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 9 These patients may have chronic borreliosis !!

10. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 10 Germ of Lyme Disease Borrelia burgdorferi sensu lato Spezies:B. burgdorferi sensu stricto B. garinii B. afzelii Carrier : hard ticks (Ixodes ricinus) (Attention : the ticks transmit CEE, only for this vaccinations are available)

11. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 11 Possible Infections by Tick bite  CEE  Borrelia  Ehrlichia  Bartonella  Rickettsia

12. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 12 Epidemiology of Borreliosis  in Germany 10 to 40 % of ticks are infected with Borrelia  for an successfull contamination the ticks should suck up to > 6 hours (the shorter, the more unlikely are infections)  Infections from April to October early manifestation in June - peak at August  In Germany annualy up to 60.000 new infections with clinical manifestations

13. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 13 Infection by ticks (Ixodes ricinus) Early onset  Erythema migrans (50% of all cases)  Influenzalike symptoms  Cephalgia  Facial nerv palsy  Cardial arhythmia

14. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 14 Conventional Medicine says  Most valid diagnosis by skin biopsy or arthrocentesis of joint effusion  Assay of IG G and IG M of Borreliosis is only a presumption diagnosis Prof. Stanek, University of Vienna Ärztemagazin, July 2008

15. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 15 Borrelia burgdorferi – Course of Infection Bite of a infected tick Infection Stadium I Stadium II Stadium III 5 - 48 days Period of 4-6 weeks, Autotherapy very likely Period of 4-6 months Autotherapy still possible Moths till years p.i. NO autotherapy !! 4 -12 Wo. p.i Transmission of Borrelia Local breeding of Borrelia

16. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 16 Labratory  If IGM and IG G of Borrelia are positiv remains the question:  Expired infection or active infection?  Indication for LTT to Borrelia = Lymphocytes Transformation Test Lymphocytes Transformation Test

17. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 17 Lymphocytes Transformation Test 1.Extraction of lymphocytes and monocytes out of heparinized blood by densitiy-gradient centrifugaionfugation 2. Transformation of 1,2 x 10 6/ ml vital cells on to a cell cultural kit (3 times) Lympho-/Monocytes Erythro- and Granulocytes Serum 3. Adding of antigenes of Borrelia (z.B. OspC) Day 0 „sleeping T-cells“ 4. Incubation for 6 days, 37°C, 5%CO 2

18. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 18 Result afer 6 days: 6 6. Measurement of DNA-Newsynthesis in Beta-Counter 5 5. Quantification of antigen-induced DNA-newsynthesis by assay of 3 H-Thymidine-built-in Negative result Positive result clonal prolifeated antigen- spezific T-Lymphozyten 7 7. Outcome as SI = Antigen-induced T*-built-in blank measurement-T*-built-in

19. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 19 Result of positive LTT a positive LTT of Borrelia says: There are Borrelia- spezific T- memory-cells in the blood, the infection is active!! After a study of Hopf-Seidel on 210 Patients,2007, 9% of the patients had negative serum findings but positive LTT! Every tenth of patients has false negative findings! Donta is reporting 2002 of 20% negative false findings in serum assays Are Borrelia-spezific memory- T-cells in the blood of the patient ?

20. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 20 Hypothesis of persisting or chronic Borreliosis  Insufficient diagnosis and therapy ( often in conventional medicine )  Inducing of immunogene reactions by Borreliosis ( Prof. v. Baehr )  Persisting Neurotoxins in the fatty tissue ( Shoemaker )  Hiding of parasites in the connective tissue ( Donta )

21. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 21 Therapies Conventional Medicine: Penicilline, Ampicillin, Tetracycline, Doxcycline, Ceftriaxone, Cefaroxine, Clarithomycine, Azithromycine, Ciprofloxacine for a fortnight or 4 weeks Donta: Hihg dose antibiotics like a above, at least 1 month, when symptoms were longer at least 3 month, when symptoms last for longer than a year, treatment should last 12 to 18 month, toegether with CHLOROQINE, an antimalarial, ( Resochine, Quensyl ) Shoemaker: From 4 to 6 weeks high dose antibiotics mostly Doxycycline overlapping with colestyramine 2-4 g, when complications ( Herxheimer reaction ) Enbrel

22. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 22 Resume of problems in chronic borreliosis  Serum diagnosis is not reliable  Conventional therapies often don‘t treat sufficently  Borreliosia can probably disappear from the surface  In certain phases antibiotics don‘t reach the parasite  Symptoms of chronic borreliosis are of great variety and not specific

23. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 23 How can Applied Kinesiology Applied Kinesiology help?

24. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 24 Casereport  10 patients from 71 to 29 years  Period of symptoms: from 2 till over 15 years  7 patients have severe general symptoms ( fatigue, aching and swelling joints etc.)  3 patients have „only“ local symptoms ( aching Achilles tendon, aching knees, aching fingers)  8 had negative serological assays of Borrelia  4 of them had an postive LTT and 4 had negative LTT‘s

25. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 25 Casereport 4 patients, 2 with positive LTT and 4 patients, 2 with positive LTT and 2 with negative LTT of Borrelia showed Borrelia in the 2 with negative LTT of Borrelia showed Borrelia in the DARKFIELD MICROSCOPY !! DARKFIELD MICROSCOPY !!

26. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 26 Hypothesis and Results  There are no really reliable labratory tools in veryfying chronic borreliosis  There are clues for hiding of Borrelia spirochetes in the tissue, causing no immune reaction  The most reliable labratory tool seems to be the Lymphocytes Transformation Test  Remarkable results supplies the DARKFIELD MICROSCOPY  Chronic Borreliosis seems more widespread than ever thought

27. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 27 AK Procedure  General and local muscletesting  Any findings should negated by  homeopathic nosode of low potency  antibiotics on the tongue and CHOLOROQINE (mostly Minocyline, passing hematoencephalic barrier ) 150 to 200 mg Minocycline per day and 200 to 400 mg Cholorquine every second day

28. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 28 AK Procedure If improvement follow up examination should include, they should test normal  TL of NV suprapinatus  BE points  All alarm points  Local spots of pain Don‘t stop the treatment earlier, even the patient feels better

29. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 29 Supplementary Therapy  Nosodes of Borreliosis  Rizol oils  Colestyramine  Vitamines ( A, C, E, D, B )  Minerals ( Zinc, Calcium, Mg, Potassium )  Support of organs by phytotherapy, especially liver, gut  EFS ( linseed oil )

30. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 30 Best thanks to Prof. Rüdiger v. Baehr, Berlin Dr. Ulrike Lex, Nuremberg for their contributions

31. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 31 Thank you for your attention !!

32. Dr. Werner Klöpfer FA f. Neurologie u. Psychiatrie DIBAK Alserstrasse 43 1080 Wien ICAK Meeting Antwerp September 2008 32 Adress: Dr. Werner Kloepfer Dr. Werner Kloepfer Alserstrasse 43 A- 1080 Wien E – mail : werner.kloepfer@ spai.at