1. One Health in Action Dr. Ralph Richardson Dean, College of Veterinary Medicine Kansas State University Dr. Neil Olson Dean, College of Veterinary Medicine University of Missouri

2. Cooperation between human and veterinary medicine in selected endeavors, working locally, nationally and globally. Building on common pool of knowledge in physiology, pathology, epidemiology, etc. Simultaneous study of environmental and zoonotic diseases in people, domestic and wild animals. What is one health?

3. One Health Movement The Convergence of… Human Health Animal Health Environmental Health Ref: JAVMA One Health, July 15, 2008

5. 60% OF THE 1,462 KNOWN INFECTIOUS ILLNESSES ARE CAUSED BY AGENTS WHICH ARE MULTI-HOST PATHOGENS AND MOVE ACROSS SPECIES LINES. IN THE LAST 30 YEARS, 70% OF THE NEW HUMAN INFECTIONS HAVE BEEN ZOONOTIC.

6. Emerging infectious disease

7. Spinach outbreak 200 people, 26 states, 3 dead

8. Food-as-foe "I never thought you could die from E.coli. Never. I had heard of E.coli and I just thought it was food poisoning" she said."I never ever thought Mason would die from it.” -- Family’s call for E. coli lessons 01.nov.05 BBC News Mason Jones Dec. 24, 1999 - Oct. 6, 2005

9. Similar appearance of fully cooked and uncooked breaded products Product packaging of fully cooked vs. uncooked products Cause for consumer confusion?

12. “Between animal and human medicine there is no dividing line – nor should there be. The object is different but the experience obtained constitutes the basis of all medicine.” - Rudolf Virchow (1821-1902)

13. NEW YORK TIMES, SEPTEMBER 10, 2012 “Vets and Physicians Find Research Parallels” “One reason is a growing frustration with the inefficiency of using the rodent model in lab research, which often fails to translate to human subjects…this type of research model has led to a host of collaborative research projects aimed at speeding the journey from lab to human clinical trials, and in the end, producing a result that can be applied to human and animal patients alike.”

14. Comparative Neurology Program

15. Diseases of the Nervous System Epilepsy & movement disorders Meningitis & encephalitis Brain tumors Stroke & head injury Spinal injury & herniated disks Muscular dystrophy & other muscle diseases Comparative Neurology Program

16. What do these two have in common? http://en.wikipedia.org/wiki/Lou_Gehrig

17. From lab to clinic Identification of new genes Development of new therapies Canine genome map provided the tools

18. Cancer in Animals 50% of animals that live beyond 10 years of age will develop cancer Improved methods of diagnosis Increased demand for care

19. Cancer Incidence by Species (Age-adjusted Incidence) 381 cases/100,000 dogs per year 264 cases/100,000 cats per year 300 cases/100,000 people each year

20. Why are animal cancer models useful? Shorter life span

21. Why are animal cancer models useful? Shared environment

22. Why are animal cancer models useful? Controllable factors  Lifestyle choices  Diet  Hormonal status  Placebo effect

23. Why are animal cancer models useful? Pedigree may be known

24. The Quadramet Story at MU One Health in Action Samarium 153 developed at MU (1980s) Osteosarcoma Clinical trials in dogs (1990s) Critical data for FDA to conduct human clinical trials

25. The Quadramet Story at MU Springer Spaniel owned by St. Louis couple in early 2000s Wife’s father developed metastatic tumor in spine (2005) Treated with Quadramet 2012 couple bequested $5M of estate to MU CVM Ongoing clinical trials with next generation drug (cyclosam)

26. Cooperation between human and veterinary medicine in selected endeavors, working locally, nationally and globally Building on common pools of knowledge in physiology, pathology, epidemiology, etc. Simultaneous study of environmental and zoonotic diseases in people, domestic and wild animals Assurance of scientific rigor Identifying mutual benefit for animals and humans How will programs be built?

27. The Greater Kansas City Community Foundation “ A Time to Get it Right” and “Staying Competitive in the New Economy” “It is essential that faculty members and researchers in Kansas City’s key 4 life sciences organizations, e.g., universities, the Stowers Institute, area medical centers and life sciences businesses, be strongly encouraged to work together. Every effort should be made by organizations to remove those factors that hinder such intellectual collaboration.”