1. A Convergence of Creativity and Schizophrenia In the Brain Rex E. Jung, Ph.D. Research Scientist: The MIND Research Network Assistant Research Professor: Departments of Neurosurgery University of New Mexico

2. 4.0 Cho Cre NAA ppm 2.0 3.0 Intellectual Tests (WAIS-3)Intellectual Tests (WAIS-3) –Vocabulary –Similarities –Arithmetic –Digit Span –Information –Letter-Number Seq. –Picture Completion –Block Design –Matrix Reasoning –Digit Symbol - Coding –Symbol Search Occipito-Parietal White Matter WAIS-3 Full Scale IQ 13.012.512.011.5 r 2 =.27, p <.01 NAA (mM) in White Matter 140 130 120 110 100 90 Jung et al., (1999a). Biochemical Markers of Intelligence. Proceedings of the Royal Society of London, Series - B. 266:1375-9. Jung et al., 1999/2005 Where in the brain is intelligence? Haier, Jung et al., 2004 Schmithorst et al., 2005 Haier et al., 1988 Thompson et al., 2001 Gray et al., 2003 Duncan et al., 2000 Prabhakaran et al., 1997 Atherton et al., 2003 Shaw et al., 2006 Schmithorst et al., 2006

3. Parieto-Frontal Integration Theory “P-FIT” Jung RE & Haier RJ (2007). The Parieto-Frontal Integration Theory of Intelligence: Converging Neuroimaging Evidence. Behavioral and Brain Sciences, 30(2): 135-154.

4. Prefrontal Cortex P4 Cingulate Gyrus Caudate/Thalamus Superior Longitudinal Fasciculus Figure E-1: The proposed Intelligence network involving: 1) the dorsolateral frontal subcortical circuit (DL-FSC) comprising the caudate nucleus, thalamus, and BAs 9 & 10 in the prefrontal cortex, 2) the anterior cingulate frontal subcortical circuit (AC-FSC) comprising the caudate nucleus, thalamus, and BA 24 of the cingulate gyrus, and 3) superior longitudinal fasciculus linking posterior to frontal cortices. Figure E-2: The Parieto-Frontal Integration Theory (P-FIT) of intelligence. Schematic diagram of regions in which brain measures were related to individual differences on measures of intelligence and reasoning in HNV. Cingulum Bundle Superior longitudinal Fasciculus Figure E-4. DTI image co-registered to sMRI image showing the superior longitudinal fasciculus and cingulum bundle Figure E-3: Scatterplot of the relationship between intellectual functioning (Full Scale IQ) and NAA in SP and HNV. Note the direct relationship between NAA within frontal white matter (dashed line) and IQ in SP, while no such relationship exists in HNV. Solid line and blue dots represents occipital NAA-IQ relationships; dashed line and white dots = frontal NAA-IQ relationships. 70 80 90 10 0 11 0 12 0 910 11.0 12.0 13 0 Schizophrenic Patients 90 100 110 120 9.510.5 11 12.5 130 WASI Full Scale IQ Normal Volunteers Figure E-3 COBRE

5. CIQ BA 11 BA 21 BA 24 BA 38 Jung RE et al., (Under Review). Journal of Neuroscience. Jung RE et al., (Under Review). Human Brain Mapping. Jung RE et al., (Submitted). Science-Brevia John Templeton Foundation: Neuroscience of Creativity