1. Source of Myelin Antigens is currently unknown: Hypotheses: Viral, Genetic ??? Antigen: molecule that activates the immune system CNS immune system destroys Oligodendrocytes Result

2. Romberg Test Patient closes eyes, places feet together and hands at sides Normal: Patient should stand still Abnormal: Patient Sways

3. Abnormal Romberg Test: Sensory deficit 1)Damage to Peripheral Sensory Receptors (i.e. muscle spindle, Golgi tendon organ) Damage to PERIPHERAL NERVOUS SYSTEM is NOT PART OF MS!!!!! 2) Damage to Sensory Pathways/Neurons in Spinal Cord

4. 3) Damage to Brain neurons: cerebellum, cranial nerve VIII and cerebrum