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PASS Objectives Content Standard 2.2 A sorting and recombination of genes in reproduction results in a great variety of possible gene combinations from the offspring of any two parents.
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Gregor Mendel - 8 min
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Mendel studied 7 characteristics
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A segment of DNA controlling a trait Any of several alternative forms of a gene
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A segment of DNA controlling a trait Any of several alternative forms of a gene
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A gene that masks the effects of another A gene whose effect is masked by the dominant gene
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A gene that masks the effects of another A gene whose effect is masked by the dominant gene
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A trait for which the genes of the pair are identical A trait for which the genes of the pair are different
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A trait for which the genes of the pair are identical A trait for which the genes of the pair are different
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The genetic makeup of an organism The external appearance of an organism
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The genetic makeup of an organism The external appearance of an organism
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An offspring from parents with different traits.
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The traits of the offspring are a combination of the traits of the parents.
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DIFFERENT SAME
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DIFFERENT SAME
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DIFFERENT SAME genes are different - what kind of trait?
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DIFFERENT SAME
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DIFFERENT SAME genes are alike - what kind of trait?
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DIFFERENT SAME
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The 64 words of the language of genetics
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Which color is dominant - Red or White?
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pink is a BLEND of red & white
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Probability - 7 min
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Humans reproduce in relatively small numbers.
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Most plants and animals reproduce in LARGE numbers.
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If you flip a coin only 4 times - you may get four heads. heads - 100% tails - 0%
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If you flip a coin 400 times - you WILL get very close to: heads - 50% tails - 50%
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A Punnett Square is a tool used to predict the possible offspring of a genetic cross.
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Use a capital case first letter of the dominant trait to represent the dominant gene
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Use a capital case first letter of the dominant trait to represent the dominant gene
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Use a small case of the SAME letter to represent the recessive gene
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Use a small case of the SAME letter to represent the recessive gene
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Heterozygous Red Parent
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The possible genes from one parent go here.
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The possible genes from the other parent go here.
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Draw the squares.
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Fill in the letters.
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These are the genes (genotypes) possible in the offspring.
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1 out of 4 are RR
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2 out of 4 are Rr
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1 out of 4 are rr
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Gametes
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Gamete Combinations
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1 / 4 are RR 1 / 2 are Rr 1 / 4 are rr
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3 / 4 are Red 1 / 4 are white
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3 / 4 are Red 1 / 4 are white Remember, it only takes ONE dominant gene for that trait to show...
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3 / 4 are Red 1 / 4 are white but BOTH genes must be recessive for that trait to show.
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In certain trees, smooth bark is dominant over wrinkled. Cross two trees that are heterozygous for smooth bark. If there are 100 offspring produced, how many will have wrinkled bark?
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What are the genotypes of the parents? In certain trees, smooth bark is dominant over wrinkled. Cross two trees that are heterozygous for smooth bark.
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In certain trees, smooth bark is dominant over wrinkled. Cross two trees that are heterozygous for smooth bark. S s X S s
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How do we begin to draw the Punnett square?
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S s S s
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S s S s SSSsSs SsSs ss
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S s S s SSSsSs SsSs ss
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S s S s SSSsSs SsSs ss
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S s S s SSSsSs SsSs ss
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S s S s SSSsSs SsSs ss
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S s S s SSSsSs SsSs ss
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S s S s SSSsSs SsSs ss This is the Punnett square for the cross.
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S s S s SSSsSs SsSs ss What do we need to know?
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S s S s SSSsSs SsSs ss Which square is wrinkled bark?
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S s S s SSSsSs SsSs ss 1/4 wrinkled How do we use this to answer the question?
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S s S s SSSsSs SsSs ss 1/4 wrinkled 25 out of 100 will have wrinkled bark.
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In flying purple people eaters, one-horn is dominant and no-horn is recessive. Draw a Punnett square showing the cross between two heterozygous one-horn flying purple people eaters. Use H for one-horn and h for no-horn.
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What are the genotypes of the parents?
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What are the genotypes of the parents? H h X H h Now draw the Punnett square.
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H h H h HHHh hh H = one-horn h = no-horn
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In flying purple people eaters, one-eye is dominant and no-eye is recessive. Draw a Punnett square showing the cross between two heterozygous one-eye flying purple people eaters. Use E for one-eye and e for no-eye.
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What are the genotypes of the parents?
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What are the genotypes of the parents? E e X E e Now draw the Punnett square.
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E e E e EEEe ee E = one-eye e = no-eye
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The probability of independent events occurring together is the PRODUCT of the probabilities of the individual events.
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If two heterozygous one-eye, one-horn flying purple people eaters are crossed, what fraction of the offspring will be no-horn, no-eye flying purple people eaters?
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If two heterozygous one-eye, one-horn flying purple people eaters are crossed, what fraction of the offspring will be no-horn, no-eye flying purple people eaters? Use the 2 squares you have and the product rule to answer the question.
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How many are no-horn?
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1 / 4 will be no-horn
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1 / 4 will be no-horn How many are no-eye?
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1 / 4 will be no-horn 1 / 4 will be no-eye
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1 / 4 will be no-horn 1 / 4 will be no-eye Using the product rule - 1 / 4 X 1 / 4 = 1 / 16 1 out of 16 will be no-horn, no-eye flying purple people eaters.
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r w r w rrrw ww What's wrong with this Punnett square?
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r w r w rrrw ww A Punnett square with no capital letters show incomplete dominance.
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Dominance is incomplete in tulips. What color are the offspring when a homozygous red tulip is crossed with a homozygous white tulip?
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Use the small case first letter of each trait to represent the genes. r = red w = white
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rr rr X ww w w rw All the offspring are PINK.
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What color are the offspring when two pink tulips are crossed?
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rw rw X rw r w rrrw ww 1 / 4 red 1 / 2 pink 1 / 4 white
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Genes for sex-linked traits are located on the X chromosome.
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Colorblindness is a sex-linked trait - located on the X chromosome.
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The gene for normal color sight is X C.
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The recessive gene for colorblindness is X c.
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What would be the genotype for a colorblind female?
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What would be the genotype for a colorblind female? XcXcXcXcXcXcXcXc
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What would be the genotype for a colorblind male?
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What would be the genotype for a colorblind male? XcYXcYXcYXcY
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This female would have normal vision but would be a "carrier" of the colorblind gene. XCXcXCXcXCXcXCXc
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A S e x - L i n k e d T r a i t
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Traits are influenced by sex hormones...
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but located on a chromosome other than a sex chromosome.
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"Male-pattern baldness is a sex-influenced trait.
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Hair loss in women is usually a general thinning all over the scalp.
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Traits controlled by the additive effect of multiple alleles.
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It IS even possible for more than one pair of genes to have an effect on the same trait.
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Bell Curve Average Value Extreme Value Extreme Value
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Average Height ShortTall
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ShorterLongerSame short or long index finger
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Fold your hands together by interlocking your fingers.
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Which thumb is on top?
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Dominant - L_ Recessive - ll
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Dominant - S_Recessive - ss
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Dominant - T_Recessive - tt
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Dominant - W_Recessive - ww
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unattachedattached Dominant - E Recessive - ee
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Dominant - D_Recessive - dd
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Dominant - F_Recessive - ff
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Male
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Female
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Marriage Line
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Offspring Line
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Sibling Line
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Oldest child
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Youngest child
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Shows the trait in question
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Does not show the trait in question
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Carries the trait but does not show it
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No Widow's Peak No Tongue-rolling Attached Ear Lobes Hitch-hiker's Thumb Pick a RECESSIVE trait that YOU have Right-thumbed
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Write your name and the trait you are using at the top of the paper.
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Color in YOUR square or circle on the chart
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Take your pedigree chart home tonight and check the people on the chart that you can actually see.
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Put a question mark in the squares or circles for those you do not see.
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Bring your completed pedigree chart to class tomorrow.
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Does A food taste the same to everyone?
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WHY?
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1.Taste plain paper the control 2. Taste PTC paper describe the taste
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Phenylthiocarbamide (PTC) is a chemical produced by plants like cabbage, broccoli, Brussel sprouts, turnips, and kale.
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70% of the U.S. population detects at least some bitterness when they taste PTC.
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TT - very bitter Tt - slightly bitter tt - non-taster
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Tasters show a greater sensitivity to a wide range of tastes...
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including bitter, sweet, and oral irritants such as capsaicin in chili pepper
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Non-taster and taster status has clear implications for one's perception of taste of a wide range of foods.
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Genetic Engineering
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the application of molecular genetics for a practical purpose.
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Recombinant DNA is a combination of DNA from two or more sources.
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One of the best applications of recombinant DNA today is the production of insulin.
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The human gene for insulin production is isolated from a human cell.
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The human gene is then inserted into bacteria DNA.
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The recombinant DNA is inserted into a bacterial cell.
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When the bacteria cell reproduces, all of its offspring will have the human gene.
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Eventually, Trillions of bacteria cells are producing human insulin.
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Vats of bacteria producing insulin
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You want another one just like HIM?!!
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The nucleus (DNA) is removed from an egg cell.
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The nucleus (DNA) from a body cell is inserted into the empty egg cell.
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A structure similar to a fertilized egg cell is produced.
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The cell begins to divide and produce an embryo.
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Eventually producing a complete organism.
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Doctor, I believe your cloning protocols are wrong!
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Eugenics, altering gene pools to improve the traits in human populations, was a thriving science in the 1930's.
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Why isn't eugenics around today?
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Why isn't eugenics around today?
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Who is the father of modern genetics?
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Who is the father of modern genetics? Gregor Mendel
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How many pea traits did he follow?
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How many pea traits did he follow? 7
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What theory did Walter Sutton propose in 1903 that supported Mendel's ideas about traits?
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chromosome theory What theory did Walter Sutton propose in 1903 that supported Mendel's ideas about traits?
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A ___ is a segment of DNA controlling a trait.
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gene A ___ is a segment of DNA controlling a trait.
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A gene that masks the effect of another is ___
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dominant gene A gene that masks the effect of another is ___
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A gene whose effect is masked is ___
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recessive gene A gene whose effect is masked is ___
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A trait for which the genes of the pair are identical
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homozygous trait A trait for which the genes of the pair are identical
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A trait for which the genes of the pair are different
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heterozygous trait A trait for which the genes of the pair are different
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The genetic makeup of an organism
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genotype The genetic makeup of an organism
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The external appearance of an organism
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phenotype The external appearance of an organism
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An offspring from parents with different traits
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hybrid An offspring from parents with different traits
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Genes are combination of ___ (a number) DNA bases called codons.
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3 Genes are combination of ___ (a number) DNA bases called codons.
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The passing of traits from one generation to the next
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heredity The passing of traits from one generation to the next
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A Punnett square is based on mathematical ___
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probability A Punnett square is based on mathematical ___
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Capital letters on a Punnett square represent
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dominant genes Capital letters on a Punnett square represent
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A Punnett square with no capital letters tells you
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neither gene is dominant A Punnett square with no capital letters tells you
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What is the name of a cross involving only one trait?
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monohybrid cross What is the name of a cross involving only one trait?
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What letters go here? X
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rr
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Genes for sex-linked traits are located on the ___ chromosome.
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X Genes for sex-linked traits are located on the ___ chromosome.
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Sex-influenced traits are different in each sex because of ___
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sex hormones Sex-influenced traits are different in each sex because of ___
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Traits controlled by the additive effects of multiple alleles are called ___ traits.
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polygenic Traits controlled by the additive effects of multiple alleles are called ___ traits.
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A chart tracing the history of a trait through several generations.
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pedigree chart A chart tracing the history of a trait through several generations.
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Males are represented by
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females are represented by
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Why is this square colored in?
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He has the trait in question.
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Why is this circle half-colored in?
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She is a carrier.
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Which is the oldest child?
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The first one on the left is always oldest.
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The application of molecular genetics for a practical purpose.
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genetic engineering The application of molecular genetics for a practical purpose.
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A combination of DNA from two or more sources.
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recombinant DNA A combination of DNA from two or more sources.
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Who is the father of modern genetics?
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Who is the father of modern genetics? Gregor Mendel
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