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Nonsense Mutations in PCSK9 and Cardiovascular Risk Factors among 3363 Black Participants in the Study Jonathan C.Cohen, et al, N Engl J Med 2006;354:1264-72.

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Presentation on theme: "Nonsense Mutations in PCSK9 and Cardiovascular Risk Factors among 3363 Black Participants in the Study Jonathan C.Cohen, et al, N Engl J Med 2006;354:1264-72."— Presentation transcript:

1 Nonsense Mutations in PCSK9 and Cardiovascular Risk Factors among 3363 Black Participants in the Study Jonathan C.Cohen, et al, N Engl J Med 2006;354:1264-72

2 Distribution of Plasma LDL Cholesterol Levels (A) and Incidence of Coronary Heart Disease (B) among Black Subjects, According to the Presence or Absence of a PCSK9 142X or PCSK9 679X Allele Jonathan C.Cohen, et al, N Engl J Med 2006;354:1264-72

3 The R46L-Encoding Allele of PCSK9 and Cardiovascular Risk Factors among 9524 White Subjects in the Study* Jonathan C.Cohen, et al, N Engl J Med 2006;354:1264-72

4 Distribution of Plasma LDL Cholesterol Levels (A)and Incidence of Coronary Events (Panel B) among White Subjects, According to the Presence or Absence of a PCSK9 46L Allele Jonathan C.Cohen, et al, N Engl J Med 2006;354:1264-72


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