1. Predictive value of CRP vs LDL-C (i) Ridker PM, et al. N Engl J Med 2002;347:1557-1565. Quintile of CRP (mg/L) <0.0012.32.01.61.41.0 Adjusted RR* of a first cardio- vascular event p value>4.19>2.09 to 4.19 >1.08 to 2.09 >0.49 to 1.08 < 0.49 * relative risk adjusted for age, smoking status, the presence or absence of diabetes mellitus, blood pressure, use or nonuse of hormone replacement therapy, and treatment assignment

2. Predictive value of CRP vs LDL-C (ii) Quintile of LDL-C (mg/dL) <0.0011.51.31.10.91.0 Adjusted RR* of a first cardio- vascular event p value>153.9>132.2 to 153.9 >115.4 to 132.2 >97.6 to 115.4 < 97.6 * relative risk adjusted for age, smoking status, the presence or absence of diabetes mellitus, blood pressure, use or nonuse of hormone replacement therapy, and treatment assignment Ridker PM, et al. N Engl J Med 2002;347:1557-1565.

3. High CRP/low LDL-C predicts high risk 3.92.6 2.0 1.3 Age-adjusted event rates per 1000 person- years High CRP High LDL High CRP Low LDL Low CRP High LDL Low CRP Low LDL* * Low and high refer to levels below and above the median values of CRP (1.52 mg/L) and LDL-C (123.7 mg/dL) Ridker PM, et al. N Engl J Med 2002;347:1557-1565.