15 Mallory's hyaline is seen here, but there are also neutrophils, necrosis of hepatocytes, collagen deposition, and fatty change. These findings are typical for acute alcoholic hepatitis. Such inflammation can occur in a person with a history of alcoholism who goes on a drinking "binge" and consumes large quantities of alcohol over a short time.
16 Photomicrograph of hemochromatosis showing iron accumulation in hepatocytes. Prussian Blue stain.
17 The hepatocytes and Kupffer cells here are full of granular brown deposits of hemosiderin from accumulation of excess iron in the liver. The term "hemosiderosis" is used to denote a relatively benign accumulation of iron. The term "hemochromatosis" is used when organ dysfunction occurs. The iron accumulation may lead to a micronodular cirrhosis (so called "pigment" cirrhosis).
18 Glycogenated nuclei and sparse lobular inflammation in Wilson’s Disease.
19 PAS+, diastase resistant globules in A1AT deficiency.
20 Immunostain for alpha-one antitrypsin showing accumulation in hepatocytes
21 Lymphocytes infiltrate and destroy the bile duct, constituting the “florid duct lesion” of primary biliary cirrhosis.
22 This is a case of primary biliary cirrhosis, a rare autoimmune disease (mostly of middle-aged women) that is characterized by destruction of bile ductules within the triads of the liver. Antimitochondrial antibody can be detected in serum. Seen here in a portal tract is an intense chronic inflammatory infiltrate with loss of bile ductules. Micronodular cirrhosis ensues.
23 Bile ducts are destroyed and replaced by fibrous nodular scars in primary sclerosing cholangitis. Male predominance
24 Cavernous hemangioma; note large blood-filled channels
25 Focal nodular hyperplasia; note large central stellate scar and surrounding nodules of liver parenchymaScarParenchymalnodules
26 Focal Nodular Hyperplasia; note large central stellate scar
33 Hepatocellular carcinoma. Note hyaline globules and eosinophilic cytoplasm.Hyaline globule
34 Note that this hepatocellular carcinoma is composed of liver cords that are much wider than the normal liver plate that is two cells thick. There is no discernable normal lobular architecture, though vascular structures are present.
35 Fibrolamellar hepatocellular carcinoma. Note central scar Fibrolamellar hepatocellular carcinoma. Note central scar. -- better prognosis
57 High power view of islet cell tumor (left). Note how cells resemble normal islet at right.
58 The islet cell adenoma at the left contrasts with the normal pancreas with islets at the right. Some of these adenomas function. Those that produce insulin may lead to hypoglycemia. Those that produce gastrin may lead to multiple gastric and duodenal ulcerations (Zollinger-Ellison syndrome).