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Fig. 2 Extended local release of agonists of innate immunity prevents tumor recurrence and eliminates distal metastases. Extended local release of agonists.

Published byΒηθεσδά Μαυρίδης Modified over 4 years ago

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Presentation on theme: "Fig. 2 Extended local release of agonists of innate immunity prevents tumor recurrence and eliminates distal metastases. Extended local release of agonists."— Presentation transcript:

1 Fig. 2 Extended local release of agonists of innate immunity prevents tumor recurrence and eliminates distal metastases. Extended local release of agonists of innate immunity prevents tumor recurrence and eliminates distal metastases. Tumors were resected from mice 10 days after orthotopic inoculation of 4T1-Luc2 cells, and hydrogels loaded with the following payloads were evaluated: anti–PD-1, anti-CTLA-4, IL-15sa, lenalidomide, celecoxib, STING-RR, or R848. Mice that did not receive a hydrogel were examined as a negative control. (A) IVIS imaging of 4T1-Luc2 cells is shown for all groups described and illustrates tumor burden. (B) Kaplan-Meier curves are shown comparing hydrogels loaded with antibodies that induce immune checkpoint blockade to no hydrogel. (C) Kaplan-Meier curves are shown comparing a hydrogel loaded with the potent cytokine IL-15sa to no hydrogel. (D) Kaplan-Meier curves are shown comparing hydrogels loaded with various immunomodulatory small molecules to no hydrogel. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times. Statistics were calculated relative to the group treated with no hydrogel using the log-rank (Mantel-Cox) test. **P ≤ 0.01, ***P ≤ d, days; n/a, not achieved. Chun Gwon Park et al., Sci Transl Med 2018;10:eaar1916 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

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