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G3139 substitutes for heparin, which is required for the biological activity of FGF2. G3139 substitutes for heparin, which is required for the biological.

Published byRatna Sanjaya Modified over 4 years ago

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Presentation on theme: "G3139 substitutes for heparin, which is required for the biological activity of FGF2. G3139 substitutes for heparin, which is required for the biological."— Presentation transcript:

1 G3139 substitutes for heparin, which is required for the biological activity of FGF2.
G3139 substitutes for heparin, which is required for the biological activity of FGF2. C11 cells were washed twice with medium without interleukin-3 and seeded (2.2 × 104 per well in 48-well plates) in medium containing 10% fetal bovine serum but not interleukin-3. The cells were then treated with 1 nmol/L FGF2 + G3139 (1 μmol/L). After 2 d, proliferation was evaluated by sulforhodamine blue staining. Columns, average (n = 3); bars, SD. FGF2 + Hep versus FGF2: P < 0.001; FGF2 + G3139 versus FGF2: P < 0.002; G3139 or Hep versus control: P > 0.05 (not significant). Hep, heparin. C.A. Stein et al. Clin Cancer Res 2009;15: ©2009 by American Association for Cancer Research

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