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FGFR1 Amplification in Squamous Cell Carcinoma of The Lung

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Presentation on theme: "FGFR1 Amplification in Squamous Cell Carcinoma of The Lung"— Presentation transcript:

1 FGFR1 Amplification in Squamous Cell Carcinoma of The Lung
Rebecca S. Heist, MD, MPH, Mari Mino-Kenudson, MD, Lecia V. Sequist, MD, MPH, Swathi Tammireddy, MBBS, Laura Morrissey, BA, David C. Christiani, MD, Jeffrey A. Engelman, MD, PhD, A. John Iafrate, MD, PhD  Journal of Thoracic Oncology  Volume 7, Issue 12, Pages (December 2012) DOI: /JTO.0b013e31826aed28 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 FGFR amplification. FISH analysis of FGFR1 demonstrates FGFR1 gene amplification in this tumor. Amplified FGFR1 appears as a cluster of isolated red signals; note that this is present in some and not all tumor cells. FGFR1, fibroblast growth factor receptor 1; FISH, fluorescence in situ hybridization. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31826aed28) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 3 A, Overall survival by FGFR1 amplification status. B, Overall Survival by FGFR1 amplification status in stage 1 to 2. FGFR1. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31826aed28) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 2 Molecular alterations in squamous cell. Observed frequency of p53 in our cohort is likely an underestimate of true p53 alterations because of the limitations of the SNaPshot assay, which focuses on hotspot mutations. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31826aed28) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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