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EGFR and HER2 Genomic Gain in Recurrent Non-small Cell Lung Cancer After Surgery: Impact on Outcome to Treatment with Gefitinib and Association with EGFR.

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Presentation on theme: "EGFR and HER2 Genomic Gain in Recurrent Non-small Cell Lung Cancer After Surgery: Impact on Outcome to Treatment with Gefitinib and Association with EGFR."— Presentation transcript:

1 EGFR and HER2 Genomic Gain in Recurrent Non-small Cell Lung Cancer After Surgery: Impact on Outcome to Treatment with Gefitinib and Association with EGFR and KRAS Mutations in a Japanese Cohort  Marileila Varella-Garcia, PhD, Tetsuya Mitsudomi, MD, Yashushi Yatabe, MD, Takayuki Kosaka, MD, Eiji Nakajima, MD, Ana Carolina Xavier, MD, Margaret Skokan, BS, Chan Zeng, PhD, Wilbur A. Franklin, MD, Paul A. Bunn, MD, Fred R. Hirsch, MD, PhD  Journal of Thoracic Oncology  Volume 4, Issue 3, Pages (March 2009) DOI: /JTO.0b013e a3 Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Frequencies of tumors with distinct categories for the epidermal growth factor receptor-fluorescence in situ hybridization (EGFR-FISH) (A) and the HER2 FISH (B) assays. Negative category includes disomy to low polysomy. Positive category includes high polysomy and gene amplification. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e a3) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Hybridization of the non small-cell lung cancer (NSCLC) sections with the epidermal growth factor receptor EGFR/CEP7 (A, B, D) and the PathVysion probe set (C) showing EGFR high polysomy (A), EGFR clustered gene amplification (B), HER2 gene amplification (C) and EGFR amplification as double minutes (D). Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e a3) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Effect on survival from the day of initiating gefitinib treatment in recurrent non small-cell lung cancer (NSCLC) after surgery by epidermal growth factor receptor fluorescence in situ hybridization (EGFR FISH) status (A), HER2 FISH status (B), and EGFR high polysomy and gene amplification (C). Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e a3) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Effect on survival from the day of initiating gefitinib treatment in recurrent non small-cell lung cancer (NSCLC) after surgery by epidermal growth factor receptor (EGFR) activating mutation (A) and KRAS mutation (B) status. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e a3) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

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