1. Cutaneous Lymphoma Associated With Epstein-Barr Virus Infection in 2 Patients Treated With Methotrexate 
Anne Tournadre, MD, Michel D'Incan, MD, PhD, Jean-Jacques Dubost, MD, Frédéric Franck, MD, Pierre Déchelotte, MD, PhD, Pierre Souteyrand, MD, Martin Soubrier, MD, PhD 
Mayo Clinic Proceedings 
Volume 76, Issue 8, Pages (August 2001)
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2. Figure 1 Case 1. Erythematous and purpuric papular eruption.
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3. Figure 2
Case 1. Skin biopsy specimen shows dermal lympho-cytic infiltrate with large cells (hematoxylin-eosin, original magnification ×40).
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4. Figure 3
Case 1. Skin biopsy specimen shows large cells expressing CD30 antigen (hematoxylin-eosin, original magnification ×40).
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5. Figure 4
Case 1. T-cell receptor γ chain gene rearrangement. Lane 1: blood sample. Lanes 2, 3: 2 lesional skin samples. Lanes 4, 5, 6: positive controls, serial dilutions of RPMI T-cell clonal line diluted in a polyclonal DNA (5%, 10%, 50%, respectively). Lane 7: negative control (water without DNA). Lane 8: negative control (polyclonal DNA). Arrows = T-cell rearrangement in positive controls. Stars = T-cell rearrangement in the skin sample.
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6. Figure 5
Case 2. Skin biopsy specimen shows hypodermal perivascular lymphocytic infiltrate with large cells (hematoxylineosin, original magnification ×40).
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7. Figure 6
Case 2. In situ hybridization of a skin biopsy specimen shows a strong and diffuse expression of EBER1 RNA (alkaline phosphatase revelation, chromogen/substrate system; BCIP/NBT; counterstain, eosin; original magnification ×40).
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