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Long-Term Complete Regression of Nodal Marginal Zone Lymphoma Transformed Into Diffuse Large B-Cell Lymphoma With Highly Active Antiretroviral Therapy.

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Presentation on theme: "Long-Term Complete Regression of Nodal Marginal Zone Lymphoma Transformed Into Diffuse Large B-Cell Lymphoma With Highly Active Antiretroviral Therapy."— Presentation transcript:

1 Long-Term Complete Regression of Nodal Marginal Zone Lymphoma Transformed Into Diffuse Large B-Cell Lymphoma With Highly Active Antiretroviral Therapy Alone in Human Immunodeficiency Virus Infection  Ioannis G. Baraboutis, MD, Vasilios Papastamopoulos, MD, Ourania Georgiou, MD, Athanasios T. Skoutelis, MD  The American Journal of the Medical Sciences  Volume 338, Issue 6, Pages (December 2009) DOI: /MAJ.0b013e3181b51fa3 Copyright © 2009 Southern Society for Clinical Investigation Terms and Conditions

2 Figure 1 (A) Hematoxylin and eosin staining of tonsillar biopsy. (B) In situ hybridization for Epstein-Barr–encoded RNA (EBER) (arrows), suggesting the presence of EBV. (C) Immunophenotyping for cytoplasmic expression of immunoglobulin light chains (κ,λ) showing strong cytoplasmic expression for λ light chain in most of the neoplastic cells (tonsillar biopsy). (D) Comparative DNA (polymerase chain reaction) analysis of the biopsy material from the tonsil and the cervical lymph node showed identical clonal rearrangements of the heavy-chain immunoglobulin genes (IgH), thus confirming the presence of the same neoplastic clone in both. The American Journal of the Medical Sciences  , DOI: ( /MAJ.0b013e3181b51fa3) Copyright © 2009 Southern Society for Clinical Investigation Terms and Conditions

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