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Jonathan S. Rogers, MD, Sammy Zakaria, MD, Kerri A

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Presentation on theme: "Jonathan S. Rogers, MD, Sammy Zakaria, MD, Kerri A"— Presentation transcript:

1 Immune Reconstitution Inflammatory Syndrome and Human Immunodeficiency Virus- Associated Myocarditis 
Jonathan S. Rogers, MD, Sammy Zakaria, MD, Kerri A. Thom, MD, MS, Kristin M. Flammer, MD, Mettassebia Kanno, MD, Mandeep R. Mehra, MD  Mayo Clinic Proceedings  Volume 83, Issue 11, Pages (November 2008) DOI: / Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions

2 FIGURE 1 Telemetry tracing demonstrating polymorphic ventricular tachycardia during an episode of syncope in the emergency department. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions

3 FIGURE 2 Photomicrograph showing diffuse lymphohistiocytic inflammatory infiltration of the lateral wall of the left ventricle with necrotic cardiomyocytes (hematoxylin-eosin, original magnification×400). Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions

4 FIGURE 3 Photomicrographs demonstrating lymphocytic myocarditis in the lateral wall of the left ventricle, representative of the infiltration seen in the entire myocardium. Fragmentation is visible, but no vasculitic lesions are evident. Lymphocyte staining was negative with CD4 antibody (left) but positive with CD8 antibody (right) (for both parts, original magnification ×100). Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions

5 FIGURE 4 Photomicrograph showing diffuse inflammatory infiltration with prominent intranuclear viral inclusions in lung section stained with antibodies directed against cytomegalovirus (original magnification ×400). Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2008 Mayo Foundation for Medical Education and Research Terms and Conditions


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