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AJKD Atlas of Renal Pathology: Sickle Cell Nephropathy

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Presentation on theme: "AJKD Atlas of Renal Pathology: Sickle Cell Nephropathy"— Presentation transcript:

1 AJKD Atlas of Renal Pathology: Sickle Cell Nephropathy
Mark A. Lusco, MD, Agnes B. Fogo, MD, Behzad Najafian, MD, Charles E. Alpers, MD  American Journal of Kidney Diseases  Volume 68, Issue 1, Pages e1-e3 (July 2016) DOI: /j.ajkd Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

2 Figure 1 Sickle cell nephropathy with glomerular capillary occlusion and extensive peritubular capillary congestion by sickled cells during a sickle cell crisis (hematoxylin and eosin stain). Reproduced with permission from AJKD 37(5):e34-e35.1. American Journal of Kidney Diseases  , e1-e3DOI: ( /j.ajkd ) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

3 Figure 2 Sickle cell nephropathy with red blood cell congestion in a glomerular capillary loop during a sickle cell crisis (hematoxylin and eosin stain). Reproduced with permission from AJKD 37(5):e34-e35.1. American Journal of Kidney Diseases  , e1-e3DOI: ( /j.ajkd ) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

4 Figure 3 Sickle cell nephropathy with marked sickling in vasa recta during an acute sickle cell crisis (hematoxylin and eosin stain). Reproduced with permission from AJKD 37(5):e34-e35.1. American Journal of Kidney Diseases  , e1-e3DOI: ( /j.ajkd ) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

5 Figure 4 Sickle cell nephropathy with iron deposits in glomerular visceral epithelial cells and tubular epithelial cells (bottom left corner; Prussian blue iron stain). Reproduced with permission from AJKD 37(5):e34-e35.1. American Journal of Kidney Diseases  , e1-e3DOI: ( /j.ajkd ) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

6 Figure 5 Sickle cell nephropathy with hemosiderin in tubular epithelial cells (A; hematoxylin and eosin stain) that shows positivity by iron stain (B; Prussian blue iron stain). American Journal of Kidney Diseases  , e1-e3DOI: ( /j.ajkd ) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

7 Figure 6 Sickle cell nephropathy with red blood cell congestion and sickled cells in glomerular capillary loops (electron microscopy). American Journal of Kidney Diseases  , e1-e3DOI: ( /j.ajkd ) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions


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