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Mark A. Lusco, MD, Agnes B. Fogo, MD, Behzad Najafian, MD, Charles E

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Presentation on theme: "Mark A. Lusco, MD, Agnes B. Fogo, MD, Behzad Najafian, MD, Charles E"— Presentation transcript:

1 AJKD Atlas of Renal Pathology: Membranous Lupus Nephritis, ISN/RPS Class V 
Mark A. Lusco, MD, Agnes B. Fogo, MD, Behzad Najafian, MD, Charles E. Alpers, MD  American Journal of Kidney Diseases  Volume 70, Issue 2, Pages e13-e15 (August 2017) DOI: /j.ajkd Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

2 Figure 1 Membranous lupus nephritis ISN/RPS class V with diffuse holes (blue arrow) and small spikes (red arrow) along glomerular basement membranes with mild mesangial expansion and proliferation (Jones silver stain). Adapted with permission from AJKD 32(1):e1-e2.1. American Journal of Kidney Diseases  , e13-e15DOI: ( /j.ajkd ) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

3 Figure 2 Membranous lupus nephritis ISN/RPS class V and focal lupus nephritis ISN/RPS class III with small spikes (red arrow) and holes (blue arrow) along glomerular basement membranes with contour duplication and early crescent formation (Jones silver stain). Adapted with permission from AJKD 32(1):e1-e2.1. American Journal of Kidney Diseases  , e13-e15DOI: ( /j.ajkd ) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

4 Figure 3 Membranous lupus nephritis ISN/RPS class V with diffuse global granular capillary loop and mesangial staining (immunofluorescence microscopy, IgG). Reproduced with permission from AJKD 32(1):e1-e2.1. American Journal of Kidney Diseases  , e13-e15DOI: ( /j.ajkd ) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

5 Figure 4 Membranous lupus nephritis ISN/RPS class V with frequent subepithelial with lesser mesangial deposits (blue arrow; electron microscopy). Adapted with permission from AJKD 32(1):e1-e2.1. American Journal of Kidney Diseases  , e13-e15DOI: ( /j.ajkd ) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

6 Figure 5 Membranous lupus nephritis ISN/RPS class V and diffuse lupus nephritis ISN/RPS class IV with numerous subepithelial (green arrow) and intramembranous (yellow arrow), frequent mesangial (blue arrow), and occasional subendothelial (red arrow) deposits with endocapillary hypercellularity (electron microscopy). Adapted with permission from AJKD 32(1):e1-e2.1. American Journal of Kidney Diseases  , e13-e15DOI: ( /j.ajkd ) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

7 Figure 6 Membranous lupus nephritis ISN/RPS class V with subepithelial deposits and reticular aggregates (blue arrows) in the cytoplasm of endothelial cells (electron microscopy). Adapted with permission from AJKD 32(1):e1-e2.1. American Journal of Kidney Diseases  , e13-e15DOI: ( /j.ajkd ) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions


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