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Nat. Rev. Nephrol. doi: /nrneph

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Presentation on theme: "Nat. Rev. Nephrol. doi: /nrneph"— Presentation transcript:

1 Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.183
Figure 3 Senescent cell accumulation in the kidney associated with ageing, disease, and therapy Figure 3 | Senescent cell accumulation in the kidney associated with ageing, disease, and therapy. Senescent cells have been identified in a variety of locations within the nephron in association with renal ageing (part a), disease (part b), and therapy-induced damage (part c). a | Senescent cells are present in aged kidneys and are associated with glomerulosclerosis, interstitial fibrosis, and nephron atrophy. b | p16INK4a-positive or senescent cells are also present in kidneys in association with several renal diseases including chronic kidney disease (CKD), membraneous nephropathy (MN), focal segmental glomerular sclerosis (FSGS), minimal change disease (MCD); IgA nephropathy (IgAN), diabetic nephropathy, nephronophthisis (NPHP), and acute kidney injury (AKI). c | Senescent cells are also induced by transplant-associated stress. SASP, senescence-associated secretory phenotype. Sturmlechner, I. et al. (2016) Cellular senescence in renal ageing and disease Nat. Rev. Nephrol. doi: /nrneph

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Figure 1 Schematic representation of idiopathic nephrotic syndrome,

Figure 1 Schematic representation of idiopathic nephrotic syndrome,
Volume 81, Issue 2, Pages (January 2012)

Volume 81, Issue 2, Pages (January 2012)
Figure 1 Disruption of phosphate homeostasis in chronic kidney disease (CKD) Figure 1 | Disruption of phosphate homeostasis in chronic kidney disease (CKD).

Figure 1 Disruption of phosphate homeostasis in chronic kidney disease (CKD) Figure 1 | Disruption of phosphate homeostasis in chronic kidney disease (CKD).
Volume 70, Issue 10, Pages (November 2006)

Volume 70, Issue 10, Pages (November 2006)
Figure 5 A layered approach to the follow-up of patients with acute kidney disease (AKD) Figure 5 | A layered approach to the follow-up of patients with.

Figure 5 A layered approach to the follow-up of patients with acute kidney disease (AKD) Figure 5 | A layered approach to the follow-up of patients with.
Figure 4 Interplay between acute kidney injury (AKI),

Figure 4 Interplay between acute kidney injury (AKI),
Figure 3 LncRNAs in kidney disease

Figure 3 LncRNAs in kidney disease
Figure 5 Inter-relationships between sleep apnoea, CKD and brain injury Figure 5 | Inter-relationships between sleep apnoea, CKD and brain injury. In chronic.

Figure 5 Inter-relationships between sleep apnoea, CKD and brain injury Figure 5 | Inter-relationships between sleep apnoea, CKD and brain injury. In chronic.
Figure 2 Pathology of scleroderma renal crisis

Figure 2 Pathology of scleroderma renal crisis
Figure 3 Energy metabolism regulation, cardiovascular and bone disease in CKD Figure 3 | Energy metabolism regulation, cardiovascular and bone disease.

Figure 3 Energy metabolism regulation, cardiovascular and bone disease in CKD Figure 3 | Energy metabolism regulation, cardiovascular and bone disease.
Figure 6 Approach to drug management in patients with acute kidney disease (AKD) Figure 6 | Approach to drug management in patients with acute kidney disease.

Figure 6 Approach to drug management in patients with acute kidney disease (AKD) Figure 6 | Approach to drug management in patients with acute kidney disease.
Figure 4 Expression of coagulation protease receptors in renal cells

Figure 4 Expression of coagulation protease receptors in renal cells
Figure 4 Interactions between adipose, the microbiome and kidney

Figure 4 Interactions between adipose, the microbiome and kidney
Nat. Rev. Nephrol. doi: /nrneph

Nat. Rev. Nephrol. doi: /nrneph
Figure 1 Mechanisms of kidney injury in the setting of obesity

Figure 1 Mechanisms of kidney injury in the setting of obesity
Figure 2 Physiological changes in the renal system in pregnancy

Figure 2 Physiological changes in the renal system in pregnancy
Figure 1 Types of coronary artery calcification

Figure 1 Types of coronary artery calcification
Figure 2 Proinflammatory mechanisms in CKD

Figure 2 Proinflammatory mechanisms in CKD
Figure 1 The epigenetic landscape mediates the interplay between stressors and renal dysfunction Figure 1 | The epigenetic landscape mediates the interplay.

Figure 1 The epigenetic landscape mediates the interplay between stressors and renal dysfunction Figure 1 | The epigenetic landscape mediates the interplay.
Nat. Rev. Nephrol. doi: /nrneph

Nat. Rev. Nephrol. doi: /nrneph

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