Presentation is loading. Please wait.

Presentation is loading. Please wait.

Eniko Sonkoly, MD, Anja Muller, MD, Antti I

Published byCostanza Napoli Modified over 5 years ago

Similar presentations

Presentation on theme: "Eniko Sonkoly, MD, Anja Muller, MD, Antti I"— Presentation transcript:

1 IL-31: A new link between T cells and pruritus in atopic skin inflammation 
Eniko Sonkoly, MD, Anja Muller, MD, Antti I. Lauerma, MD, PhD, Andor Pivarcsi, PhD, Hortensia Soto, PhD, Lajos Kemeny, MD, PhD, Harri Alenius, PhD, Marie-Caroline Dieu-Nosjean, PhD, Stephan Meller, MD, Juliane Rieker, MD, Martin Steinhoff, MD, PhD, Thomas K. Hoffmann, MD, Thomas Ruzicka, MD, Albert Zlotnik, PhD, Bernhard Homey, MD  Journal of Allergy and Clinical Immunology  Volume 117, Issue 2, Pages (February 2006) DOI: /j.jaci Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Quantitative real-time PCR analysis of IL-31 mRNA in healthy skin (n = 12), psoriasis (n = 24), nonlesional (n = 10) or lesional (n = 25) skin of atopic dermatitis (AD), and lesional skin (n = 5) of prurigo nodularis. Results are shown as relative units compared with 18S RNA. Measurements of individual samples and means + SDs are shown. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001, Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Regulation of IL-31 expression in atopic individuals in vivo. Quantitative real-time PCR analysis of IL-31 mRNA in skin samples of patients with atopic dermatitis (A) subjected to patch test with house dust mite allergen (n = 6) or (B) SEB (n = 6) for 0, 2, 6, and 48 hours. Results are shown as relative units compared with 18S RNA. ∗P < .05, Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Regulation of IL-31 expression in leukocytes. A-D, IL-31, CCL17, CCL26, and CXCL10 expression in peripheral blood mononuclear cells (PBMCs) treated with HSV, influenza virus, IFN-γ, SEB, or IL-4. Means + SDs of 3 donors. E, IL-31 expression in PBMCs after treatment with SEB or TSST-1 and (F) in PBMCs from healthy subjects (n = 5) and patients with atopic dermatitis (AD; n = 5) treated with IL-2, anti-CD3, or SEB. Quantitative real-time PCR analysis. Results are shown as relative units compared with 18S RNA, or as femtograms of target gene in 25 ng total cDNA. ∗P < .05; ∗∗P < .01, Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

5 Fig 4 Expression pattern of OSMR (A) and IL-31RA (B) in human tissues and organs. RNA from 300 samples representing 63 tissues from 2 male and 2 female donors were processed for microarray analysis by using Affymetrix Human Genome U133 Plus 2.0 gene array. Data are expressed as relative units (average intensity values). Means + SDs are shown. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Download ppt "Eniko Sonkoly, MD, Anja Muller, MD, Antti I"

Similar presentations

TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis  Maya Zimmermann, PhD, Andrea Koreck, MD, Norbert.

TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis  Maya Zimmermann, PhD, Andrea Koreck, MD, Norbert.
“Inflammatory skin march”: IL-1–mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events  Keiichi Yamanaka, MD, PhD, Hitoshi.

“Inflammatory skin march”: IL-1–mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events  Keiichi Yamanaka, MD, PhD, Hitoshi.
Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology  Saakshi Khattri, MD, Avner.

Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology  Saakshi Khattri, MD, Avner.
Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2  Natalija Novak, MD, Nihal Mete, MD, Caroline.

Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2  Natalija Novak, MD, Nihal Mete, MD, Caroline.
Topical application of a vitamin D3 analogue and corticosteroid to psoriasis plaques decreases skin infiltration of TH17 cells and their ex vivo expansion 

Topical application of a vitamin D3 analogue and corticosteroid to psoriasis plaques decreases skin infiltration of TH17 cells and their ex vivo expansion 
Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis  Ana Rebane, PhD, Maya Zimmermann, PhD, Alar Aab,

Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis  Ana Rebane, PhD, Maya Zimmermann, PhD, Alar Aab,
Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions  Asako Ichihara, MD, PhD, Zhongzhi Wang, PhD, Masatoshi Jinnin,

Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions  Asako Ichihara, MD, PhD, Zhongzhi Wang, PhD, Masatoshi Jinnin,
MicroRNA-146a suppresses IL-17–mediated skin inflammation and is genetically associated with psoriasis  Ankit Srivastava, MTech, Pernilla Nikamo, PhD,

MicroRNA-146a suppresses IL-17–mediated skin inflammation and is genetically associated with psoriasis  Ankit Srivastava, MTech, Pernilla Nikamo, PhD,
Natalija Novak, MD  Journal of Allergy and Clinical Immunology 

Natalija Novak, MD  Journal of Allergy and Clinical Immunology 
Cell-to-cell contact between activated CD4+ T lymphocytes and unprimed monocytes interferes with a TH1 response  Miriam Wittmann, MD, Mareike Alter, Tanja.

Cell-to-cell contact between activated CD4+ T lymphocytes and unprimed monocytes interferes with a TH1 response  Miriam Wittmann, MD, Mareike Alter, Tanja.
Airway microbiome and responses to corticosteroids in corticosteroid-resistant asthma patients treated with acid suppression medications  Elena Goleva,

Airway microbiome and responses to corticosteroids in corticosteroid-resistant asthma patients treated with acid suppression medications  Elena Goleva,
Epigenetic regulation of established human type 1 versus type 2 cytokine responses  Ruey-Chyi Su, PhD, Allan B. Becker, MD, Anita L. Kozyrskyj, PhD, Kent.

Epigenetic regulation of established human type 1 versus type 2 cytokine responses  Ruey-Chyi Su, PhD, Allan B. Becker, MD, Anita L. Kozyrskyj, PhD, Kent.
Protein contact dermatitis to asparagus

Protein contact dermatitis to asparagus
Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis  Eva Gros, MSc, Susanne Petzold,

Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis  Eva Gros, MSc, Susanne Petzold,
Differential cytokine induction by the human skin–associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy control.

Differential cytokine induction by the human skin–associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy control.
Atopic dermatitis: Age and race do matter!

Atopic dermatitis: Age and race do matter!
MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated.

MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated.
Histamine H2 receptor stimulation upregulates TH2 chemokine CCL17 production in human M2a macrophages  Susanne Mommert, PhD, Karl Gregor, MD, Kristine.

Histamine H2 receptor stimulation upregulates TH2 chemokine CCL17 production in human M2a macrophages  Susanne Mommert, PhD, Karl Gregor, MD, Kristine.
Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum  Lianghua Bin, MD, PhD, Michael G. Edwards,

Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum  Lianghua Bin, MD, PhD, Michael G. Edwards,
Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment  Lennart M. Roesner, PhD, Petra Kienlin, Gabriele.

Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment  Lennart M. Roesner, PhD, Petra Kienlin, Gabriele.

Similar presentations

Ads by Google