1. HIS-24 regulates expression of infection-inducible genes.
HIS-24 regulates expression of infection-inducible genes. (A) Volcano plot shows protein expression between the wild type and his-24 null mutant. Log2 protein ratios are plotted against negative log10 P values performed from triplicates. Red dots represent selected infection response proteins (Table 1). The green dot represents an absence of HIS-24 in null mutant animals. (B) Venn diagrams showing the number of genes regulated by HIS-24 and HPL using a whole-genome microarray. (C) Pie charts representing the predicted biological functions of the overlapping genes. (D) Heat maps. Each column is a sample showing significant coordinate induction (red) or repression (blue) of genes regulated by HIS-24 or HPL, respectively (FDR < 0.05). The values are z-score scaled over the rows. WT, wild type.
Studencka M et al. Mol. Cell. Biol. 2012;32: