1. A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom 
Yize I. Wan, BMedSci, David P. Strachan, MD, David M. Evans, PhD, John Henderson, MD, Tricia McKeever, PhD, John W. Holloway, BSc, PhD, Ian P. Hall, DM, FRCP, Ian Sayers, BSc, PhD 
Journal of Allergy and Clinical Immunology 
Volume 127, Issue 1, Pages e3 (January 2011)
DOI: /j.jaci
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Results of the discovery GWAS. A, Quantile-quantile plot of observed versus expected log (base 10) P values for SNPs passing quality control measures in the British 1958 Birth Cohort (increased specific IgE levels). The straight line shows the distribution of SNPs under the null hypothesis. B, Manhattan plot of 459,334 autosomal SNPs with minor allele frequencies of greater than 5% and Hardy-Weinberg equilibrium P values of greater than .05 ordered by chromosome position for increased specific IgE levels.
Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
Forest plots of studied SNPs 1 to 4: rs (8q12; A), rs (8q22; B), rs (10q26; C), and rs (11q24; D). Per-allele summary effect sizes for the minor allele are shown for atopic phenotypes: increased specific IgE level (OR), positive SPT response (OR), and serum total IgE level (β coefficient). Each row represents 1 study, relative sizes of data points are proportional to the cohort sample size, and horizontal lines represent 95% CIs. Diamonds represent the meta-analyses. ∗Statistical significance (P ≤ .05).
Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Fig 3
Forest plots of studied SNPs 5 to 7: rs (13q14; A), rs (18q22; B), and rs (20p13; C). Per-allele summary effect sizes for the minor allele are shown for atopic phenotypes: increased specific IgE level (OR), positive SPT response (OR), and serum total IgE level (β coefficient). Each row represents 1 study, relative sizes of data points are proportional to the cohort sample size, and horizontal lines represent 95% CIs. Diamonds represent the meta-analyses. ∗Statistical significance (P ≤ .05).
Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions